Translational models for vascular cognitive impairment: a review including larger species

Atticus H Hainsworth* (Corresponding Author), Stuart M Allan, Johannes Boltze, Catriona Cunningham, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D Isaacs, Raj N Kalaria, Saskia A M J Lesnik Oberstein, Mark B Moss, Björn Nitzsche, Gary A Rosenberg, Julie W Rutten, Melita Salkovic-Petrisic, Aron M Troen

*Corresponding author for this work

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

BACKGROUND: Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited.

METHODS: We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high-salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations).

CONCLUSIONS: We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum; (2) rodent models of VCI are limited by paucity of white matter; and (3) further translational models, and improved cognitive testing instruments, are required.

Original languageEnglish
Article number16
Number of pages12
JournalBMC medicine
Volume15
Issue number1
Early online date25 Jan 2017
DOIs
Publication statusPublished - 2017

Keywords

  • Animals
  • Brain/pathology
  • Dementia, Vascular/genetics
  • Disease Models, Animal
  • Risk Factors

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    Hainsworth, A. H., Allan, S. M., Boltze, J., Cunningham, C., Farris, C., Head, E., Ihara, M., Isaacs, J. D., Kalaria, R. N., Lesnik Oberstein, S. A. M. J., Moss, M. B., Nitzsche, B., Rosenberg, G. A., Rutten, J. W., Salkovic-Petrisic, M., & Troen, A. M. (2017). Translational models for vascular cognitive impairment: a review including larger species. BMC medicine , 15(1), [16]. https://doi.org/10.1186/s12916-017-0793-9