Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Yi-Hsia Liu; Christine Moelzer; Gillian C. Milne; Lucia Kuffova; John V. Vincent Forrester

doi:10.1016/j.dib.2018.12.007

Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Yi-Hsia Liu, Christine Moelzer, Gillian C. Milne, Lucia Kuffova, John V. Vincent Forrester^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.

Original language	English
Pages (from-to)	140-144
Number of pages	5
Journal	Data in brief
Volume	22
Early online date	6 Dec 2018
DOIs	https://doi.org/10.1016/j.dib.2018.12.007
Publication status	Published - Feb 2019

Bibliographical note

We are grateful to the Microscopy and Histology Core Facility of the University of Aberdeen for their assistance with sample processing. This work was generously funded by the charity Saving Sight in Grampian of the University of Aberdeen Development Trust.

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Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP
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Cite this

@article{afaa23e2496d4fa189e9831a7205f4fb,

title = "Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model",

abstract = "Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.",

author = "Yi-Hsia Liu and Christine Moelzer and Milne, {Gillian C.} and Lucia Kuffova and Forrester, {John V. Vincent}",

note = "We are grateful to the Microscopy and Histology Core Facility of the University of Aberdeen for their assistance with sample processing. This work was generously funded by the charity Saving Sight in Grampian of the University of Aberdeen Development Trust. ",

year = "2019",

month = feb,

doi = "10.1016/j.dib.2018.12.007",

language = "English",

volume = "22",

pages = "140--144",

journal = "Data in brief",

issn = "2352-3409",

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T2 - HEL mouse model

AU - Liu, Yi-Hsia

AU - Moelzer, Christine

AU - Milne, Gillian C.

AU - Kuffova, Lucia

AU - Forrester, John V. Vincent

N1 - We are grateful to the Microscopy and Histology Core Facility of the University of Aberdeen for their assistance with sample processing. This work was generously funded by the charity Saving Sight in Grampian of the University of Aberdeen Development Trust.

PY - 2019/2

Y1 - 2019/2

N2 - Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.

AB - Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.

UR - http://www.mendeley.com/research/transmission-electron-microscopy-data-drusenlike-deposits-retinal-degeneration-stgirbp-hel-mouse-mod

U2 - 10.1016/j.dib.2018.12.007

DO - 10.1016/j.dib.2018.12.007

M3 - Article

SN - 2352-3409

VL - 22

SP - 140

EP - 144

JO - Data in brief

JF - Data in brief

ER -

Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Abstract

Bibliographical note

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Microscopy and Histology

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Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Abstract

Bibliographical note

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Microscopy and Histology

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