Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Yi-Hsia Liu, Christine Moelzer, Gillian C. Milne, Lucia Kuffova, John V. Vincent Forrester (Corresponding Author)

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Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.
Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalData in brief
Early online date6 Dec 2018
Publication statusPublished - Feb 2019


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