Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis

Anthony Ormerod, P Copeland, S A Shah

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A double blind left, right comparative study was carried out in 17 psoriatic subjects to examine the influence of a topically applied inhibitor of nitric oxide (NO) synthesis on the pathogenic events of psoriasis. The inhibitor NG-monomethyl-L-arginine (L-NMMA) in aqueous cream BP was applied to one plaque while aqueous cream BP alone served as control. Compared with the control, the L-NMMA-treated side showed significant (77%) inhibition of NO production and a reduction in blood flow, confirming its bioavailability. L-NMMA significantly reduced staining for endothelial cells and intercellular adhesion molecule 1, while CD1a-positive Langerhans cells and CD8-positive suppressor cytotoxic T cells increased. CD4-positive lymphocytes and epidermal proliferation, as indicated by Ki-67 staining, were unaffected by this degree of inhibition of NO synthesis, and correspondingly significant clinical improvement was not found.
Original languageEnglish
Pages (from-to)985-990
Number of pages6
JournalBritish Journal of Dermatology
Volume142
Issue number5
DOIs
Publication statusPublished - 1 May 2000

Fingerprint

omega-N-Methylarginine
Psoriasis
Nitric Oxide
CD8-Positive T-Lymphocytes
Staining and Labeling
CD4-Positive T-Lymphocytes
Langerhans Cells
Cell Adhesion Molecules
Intercellular Adhesion Molecule-1
Biological Availability
Endothelial Cells

Keywords

  • Adult
  • Aged
  • Biological Availability
  • CD4-Positive T-Lymphocytes
  • Cell Division
  • Double-Blind Method
  • Endothelium
  • Enzyme Inhibitors
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitric Oxide Synthase
  • Psoriasis
  • Regional Blood Flow
  • Treatment Outcome
  • omega-N-Methylarginine

Cite this

Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis. / Ormerod, Anthony; Copeland, P; Shah, S A.

In: British Journal of Dermatology, Vol. 142, No. 5, 01.05.2000, p. 985-990.

Research output: Contribution to journalArticle

Ormerod, Anthony ; Copeland, P ; Shah, S A. / Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis. In: British Journal of Dermatology. 2000 ; Vol. 142, No. 5. pp. 985-990.
@article{62585c4ce5db41b5990d15dd11d3a5a4,
title = "Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis",
abstract = "A double blind left, right comparative study was carried out in 17 psoriatic subjects to examine the influence of a topically applied inhibitor of nitric oxide (NO) synthesis on the pathogenic events of psoriasis. The inhibitor NG-monomethyl-L-arginine (L-NMMA) in aqueous cream BP was applied to one plaque while aqueous cream BP alone served as control. Compared with the control, the L-NMMA-treated side showed significant (77{\%}) inhibition of NO production and a reduction in blood flow, confirming its bioavailability. L-NMMA significantly reduced staining for endothelial cells and intercellular adhesion molecule 1, while CD1a-positive Langerhans cells and CD8-positive suppressor cytotoxic T cells increased. CD4-positive lymphocytes and epidermal proliferation, as indicated by Ki-67 staining, were unaffected by this degree of inhibition of NO synthesis, and correspondingly significant clinical improvement was not found.",
keywords = "Adult, Aged, Biological Availability, CD4-Positive T-Lymphocytes, Cell Division, Double-Blind Method, Endothelium, Enzyme Inhibitors, Female, Humans, Male, Middle Aged, Nitric Oxide Synthase, Psoriasis, Regional Blood Flow, Treatment Outcome, omega-N-Methylarginine",
author = "Anthony Ormerod and P Copeland and Shah, {S A}",
year = "2000",
month = "5",
day = "1",
doi = "10.1046/j.1365-2133.2000.03483.x",
language = "English",
volume = "142",
pages = "985--990",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley",
number = "5",

}

TY - JOUR

T1 - Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis

AU - Ormerod, Anthony

AU - Copeland, P

AU - Shah, S A

PY - 2000/5/1

Y1 - 2000/5/1

N2 - A double blind left, right comparative study was carried out in 17 psoriatic subjects to examine the influence of a topically applied inhibitor of nitric oxide (NO) synthesis on the pathogenic events of psoriasis. The inhibitor NG-monomethyl-L-arginine (L-NMMA) in aqueous cream BP was applied to one plaque while aqueous cream BP alone served as control. Compared with the control, the L-NMMA-treated side showed significant (77%) inhibition of NO production and a reduction in blood flow, confirming its bioavailability. L-NMMA significantly reduced staining for endothelial cells and intercellular adhesion molecule 1, while CD1a-positive Langerhans cells and CD8-positive suppressor cytotoxic T cells increased. CD4-positive lymphocytes and epidermal proliferation, as indicated by Ki-67 staining, were unaffected by this degree of inhibition of NO synthesis, and correspondingly significant clinical improvement was not found.

AB - A double blind left, right comparative study was carried out in 17 psoriatic subjects to examine the influence of a topically applied inhibitor of nitric oxide (NO) synthesis on the pathogenic events of psoriasis. The inhibitor NG-monomethyl-L-arginine (L-NMMA) in aqueous cream BP was applied to one plaque while aqueous cream BP alone served as control. Compared with the control, the L-NMMA-treated side showed significant (77%) inhibition of NO production and a reduction in blood flow, confirming its bioavailability. L-NMMA significantly reduced staining for endothelial cells and intercellular adhesion molecule 1, while CD1a-positive Langerhans cells and CD8-positive suppressor cytotoxic T cells increased. CD4-positive lymphocytes and epidermal proliferation, as indicated by Ki-67 staining, were unaffected by this degree of inhibition of NO synthesis, and correspondingly significant clinical improvement was not found.

KW - Adult

KW - Aged

KW - Biological Availability

KW - CD4-Positive T-Lymphocytes

KW - Cell Division

KW - Double-Blind Method

KW - Endothelium

KW - Enzyme Inhibitors

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Nitric Oxide Synthase

KW - Psoriasis

KW - Regional Blood Flow

KW - Treatment Outcome

KW - omega-N-Methylarginine

U2 - 10.1046/j.1365-2133.2000.03483.x

DO - 10.1046/j.1365-2133.2000.03483.x

M3 - Article

VL - 142

SP - 985

EP - 990

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 5

ER -