Abstract
A double blind left, right comparative study was carried out in 17 psoriatic subjects to examine the influence of a topically applied inhibitor of nitric oxide (NO) synthesis on the pathogenic events of psoriasis. The inhibitor NG-monomethyl-L-arginine (L-NMMA) in aqueous cream BP was applied to one plaque while aqueous cream BP alone served as control. Compared with the control, the L-NMMA-treated side showed significant (77%) inhibition of NO production and a reduction in blood flow, confirming its bioavailability. L-NMMA significantly reduced staining for endothelial cells and intercellular adhesion molecule 1, while CD1a-positive Langerhans cells and CD8-positive suppressor cytotoxic T cells increased. CD4-positive lymphocytes and epidermal proliferation, as indicated by Ki-67 staining, were unaffected by this degree of inhibition of NO synthesis, and correspondingly significant clinical improvement was not found.
Original language | English |
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Pages (from-to) | 985-990 |
Number of pages | 6 |
Journal | British Journal of Dermatology |
Volume | 142 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2000 |
Keywords
- Adult
- Aged
- Biological Availability
- CD4-Positive T-Lymphocytes
- Cell Division
- Double-Blind Method
- Endothelium
- Enzyme Inhibitors
- Female
- Humans
- Male
- Middle Aged
- Nitric Oxide Synthase
- Psoriasis
- Regional Blood Flow
- Treatment Outcome
- omega-N-Methylarginine