Trimming Surface Sugars Protects Histoplasma from Immune Attack

Gordon D. Brown

Research output: Contribution to journalArticle

6 Downloads (Pure)

Abstract

Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye's group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum.

Original languageEnglish
Article numbere00553-16
Pages (from-to)1-3
Number of pages3
JournalmBio
Volume7
Issue number2
DOIs
Publication statusPublished - 26 Apr 2016

Fingerprint

Histoplasma
Glucans
Cell Wall
Yeasts
dectin 1

Cite this

Trimming Surface Sugars Protects Histoplasma from Immune Attack. / Brown, Gordon D.

In: mBio, Vol. 7, No. 2, e00553-16, 26.04.2016, p. 1-3.

Research output: Contribution to journalArticle

Brown, Gordon D. / Trimming Surface Sugars Protects Histoplasma from Immune Attack. In: mBio. 2016 ; Vol. 7, No. 2. pp. 1-3.
@article{380da1ca964547e5827d2383c87a89d2,
title = "Trimming Surface Sugars Protects Histoplasma from Immune Attack",
abstract = "Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye's group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum.",
author = "Brown, {Gordon D.}",
note = "ACKNOWLEDGMENTS G.D.B. thanks the Wellcome Trust and MRC (United Kingdom) for funding.",
year = "2016",
month = "4",
day = "26",
doi = "10.1128/mBio.00553-16",
language = "English",
volume = "7",
pages = "1--3",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Trimming Surface Sugars Protects Histoplasma from Immune Attack

AU - Brown, Gordon D.

N1 - ACKNOWLEDGMENTS G.D.B. thanks the Wellcome Trust and MRC (United Kingdom) for funding.

PY - 2016/4/26

Y1 - 2016/4/26

N2 - Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye's group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum.

AB - Dectin-1 is an essential innate immune receptor that recognizes β-glucans in fungal cell walls. Its importance is underscored by the mechanisms that fungal pathogens have evolved to avoid detection by this receptor. One such pathogen is Histoplasma capsulatum, and in a recent article in mBio, Rappleye's group presented data showing that yeasts of this organism secrete a β-glucanase, Eng1, which acts to prune β-glucans that are exposed on the fungal cell surface [A. L. Garfoot et al., mBio 7(2):e01388-15, 2016, http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces immune recognition through Dectin-1 and subsequent inflammatory responses, enhancing the pathogenesis of H. capsulatum.

U2 - 10.1128/mBio.00553-16

DO - 10.1128/mBio.00553-16

M3 - Article

C2 - 27118584

VL - 7

SP - 1

EP - 3

JO - mBio

JF - mBio

SN - 2161-2129

IS - 2

M1 - e00553-16

ER -