Trinucleotide repeats and protein folding and disease: The perspective from studies with the androgen receptor

Folake A. Orafidiya, Iain J. McEwan*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The androgen receptor (AR), a ligand activated transcription factor plays a number of roles in reproduction, homeostasis and pathogenesis of disease. It has two major polymorphic sequences; a polyglutamine and a polyglycine repeat that determine the length of the protein and influence receptor folding, structure and function. Here, we review the role the folding of the AR plays in the pathogenesis of spinal-bulbar muscular atrophy (SBMA), a neuromuscular degenerative disease arising from expansion of the polyglutamine repeat. We discuss current management for SBMA patients and how research on AR structure function may lead to future drug treatments.

Original languageEnglish
Article numberFSO47
Pages (from-to)1-10
Number of pages10
JournalFuture Science OA
Volume1
Issue number2
Early online date15 Jul 2015
DOIs
Publication statusPublished - 1 Sep 2015

Keywords

  • androgen receptor
  • androstanolone
  • heat shock protein 70
  • heat shock protein 90
  • huntingtin
  • cell nucleus inclusion body
  • degenerative disease
  • DNA binding
  • human
  • kennedy disease
  • Multicenter Study
  • nonhuman
  • phase 2 clinical trial
  • priority journal
  • protein expression
  • Protein Folding
  • protein structure
  • Randomized Controlled Trial
  • trinucleotide repeat

ASJC Scopus subject areas

  • Medicine(all)
  • Biotechnology

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