Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

C R Simpson, N I Lone, K Kavanagh, L D Ritchie, C Robertson, Aziz Sheikh, J McMenamin

Research output: Contribution to journalArticle

18 Citations (Scopus)
4 Downloads (Pure)

Abstract

To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.

Original languageEnglish
Article number21043
Pages (from-to)1-7
Number of pages7
JournalEurosurveillance
Volume20
Issue number8
DOIs
Publication statusPublished - 26 Feb 2015

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Influenza Vaccines
Human Influenza
Population
Scotland
Confidence Intervals
Vaccination
Vaccines
Polymerase Chain Reaction
Inactivated Vaccines
Risk Reduction Behavior
Meta-Analysis
Primary Health Care

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Disease Outbreaks
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza A virus
  • Influenza Vaccines
  • Influenza, Human
  • Logistic Models
  • Male
  • Middle Aged
  • Primary Health Care
  • Reverse Transcriptase Polymerase Chain Reaction
  • Scotland
  • Seasons
  • Sentinel Surveillance
  • Sequence Analysis, DNA
  • Time Factors
  • Treatment Outcome
  • Vaccination
  • Vaccines, Inactivated
  • Young Adult
  • Journal Article
  • Research Support, Non-U.S. Gov't

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009. / Simpson, C R; Lone, N I; Kavanagh, K; Ritchie, L D; Robertson, C; Sheikh, Aziz; McMenamin, J.

In: Eurosurveillance, Vol. 20, No. 8, 21043, 26.02.2015, p. 1-7.

Research output: Contribution to journalArticle

Simpson, C R ; Lone, N I ; Kavanagh, K ; Ritchie, L D ; Robertson, C ; Sheikh, Aziz ; McMenamin, J. / Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009. In: Eurosurveillance. 2015 ; Vol. 20, No. 8. pp. 1-7.
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KW - Infant

KW - Infant, Newborn

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KW - Seasons

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