Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

C R Simpson; N I Lone; K Kavanagh; L D Ritchie; C Robertson; Aziz Sheikh; J McMenamin

doi:10.2807/1560-7917.ES2015.20.8.21043

Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

C R Simpson, N I Lone, K Kavanagh, L D Ritchie, C Robertson, Aziz Sheikh, J McMenamin

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Abstract

To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.

Original language	English
Article number	21043
Pages (from-to)	1-7
Number of pages	7
Journal	Eurosurveillance
Volume	20
Issue number	8
DOIs	https://doi.org/10.2807/1560-7917.ES2015.20.8.21043
Publication status	Published - 26 Feb 2015

Bibliographical note

Acknowledgements
The authors would like to thank staff at PCCIU, Health Protection Scotland and the Information Services Division, the general practices and virus laboratories that contributed data to the study and members of the Independent Steering Committee overseeing this work. This study was funded by a grant from the National Institute for Health Research Health Services & Delivery Research Programme (09/2000/37) (Simpson CR et al., http://dx.doi.org/10.3310/hsdr01100). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HS&DR programme, NIHR, NHS or the Department of Health. The authors also acknowledge the financial support of ECDC through their IMOVE seasonal influenza vaccination project led by Epiconcept, which allowed virology data cleaning for the 2008/09 season.

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Disease Outbreaks
Female
Humans
Infant
Infant, Newborn
Influenza A virus
Influenza Vaccines
Influenza, Human
Logistic Models
Male
Middle Aged
Primary Health Care
Reverse Transcriptase Polymerase Chain Reaction
Scotland
Seasons
Sentinel Surveillance
Sequence Analysis, DNA
Time Factors
Treatment Outcome
Vaccination
Vaccines, Inactivated
Young Adult
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2807/1560-7917.ES2015.20.8.21043Licence: CC BY

Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009
Eurosurveillance ©2015. Except where otherwise stated, all manuscripts published after 1 January 2016 will be published under the Creative Commons Attribution (CC BY) licence. The Author retains ownership of the copyright for their manuscript, but allows anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the Author and source are cited in accordance with the detailed information provided in the licence. https://creativecommons.org/licenses/by/4.0/
Final published version, 196 KBLicence: CC BY

Cite this

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abstract = "To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.",

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note = "Acknowledgements The authors would like to thank staff at PCCIU, Health Protection Scotland and the Information Services Division, the general practices and virus laboratories that contributed data to the study and members of the Independent Steering Committee overseeing this work. This study was funded by a grant from the National Institute for Health Research Health Services & Delivery Research Programme (09/2000/37) (Simpson CR et al., http://dx.doi.org/10.3310/hsdr01100). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HS&DR programme, NIHR, NHS or the Department of Health. The authors also acknowledge the financial support of ECDC through their IMOVE seasonal influenza vaccination project led by Epiconcept, which allowed virology data cleaning for the 2008/09 season.",

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T1 - Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

AU - Simpson, C R

AU - Lone, N I

AU - Kavanagh, K

AU - Ritchie, L D

AU - Robertson, C

AU - Sheikh, Aziz

AU - McMenamin, J

N1 - Acknowledgements The authors would like to thank staff at PCCIU, Health Protection Scotland and the Information Services Division, the general practices and virus laboratories that contributed data to the study and members of the Independent Steering Committee overseeing this work. This study was funded by a grant from the National Institute for Health Research Health Services & Delivery Research Programme (09/2000/37) (Simpson CR et al., http://dx.doi.org/10.3310/hsdr01100). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HS&DR programme, NIHR, NHS or the Department of Health. The authors also acknowledge the financial support of ECDC through their IMOVE seasonal influenza vaccination project led by Epiconcept, which allowed virology data cleaning for the 2008/09 season.

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N2 - To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.

AB - To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.

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KW - Infant

KW - Infant, Newborn

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KW - Middle Aged

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KW - Seasons

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KW - Time Factors

KW - Treatment Outcome

KW - Vaccination

KW - Vaccines, Inactivated

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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SP - 1

EP - 7

JO - Eurosurveillance

JF - Eurosurveillance

IS - 8

M1 - 21043

ER -

Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

Abstract

Bibliographical note

Keywords

UN SDGs

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