TY - JOUR
T1 - Two new antifungal metabolites produced by Sparassis crispa in culture and in decayed trees
AU - Woodward, S.
AU - Sultan, H. Y.
AU - Barrett, D. K.
AU - Pearce, R. B.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The basidiomycete fungus Sparassis crispa produced three antifungal compounds during submerged culture in 2% malt broth. One compound appeared to be sparassol (methyl-2-hydroxy-4-methoxy-6-methylbenzoate), first characterized in 1924. The other two, termed ScI and ScII, exhibited considerably greater antifungal activity than did sparassol against Cladosporium cucumerinum, and were characterized as methyl-2,4-dihydroxy-6-methylbenzoate (methyl orsellinate) and an incompletely determined methyl-dihydroxy-methoxy-methylbenzoate, respectively. Both compounds were found in the decayed wood of trees, where their presence was diagnostic of S. crispa infection. The possible ecological role of these compounds is discussed.
AB - The basidiomycete fungus Sparassis crispa produced three antifungal compounds during submerged culture in 2% malt broth. One compound appeared to be sparassol (methyl-2-hydroxy-4-methoxy-6-methylbenzoate), first characterized in 1924. The other two, termed ScI and ScII, exhibited considerably greater antifungal activity than did sparassol against Cladosporium cucumerinum, and were characterized as methyl-2,4-dihydroxy-6-methylbenzoate (methyl orsellinate) and an incompletely determined methyl-dihydroxy-methoxy-methylbenzoate, respectively. Both compounds were found in the decayed wood of trees, where their presence was diagnostic of S. crispa infection. The possible ecological role of these compounds is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0027534609&partnerID=8YFLogxK
U2 - 10.1099/00221287-139-1-153
DO - 10.1099/00221287-139-1-153
M3 - Article
AN - SCOPUS:0027534609
SN - 0022-1287
VL - 139
SP - 153
EP - 159
JO - Journal of General Microbiology
JF - Journal of General Microbiology
IS - 1
ER -