Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001-2007

Scottish Diabetes Research Network (SDRN) Epidemiology group

doi:10.1007/s00125-013-2937-6

Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001-2007

Scottish Diabetes Research Network (SDRN) Epidemiology group

The Roslin Institute, University of Edinburgh

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

AIMS/HYPOTHESIS: The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on the risk of cancer at 16 different sites, while specifically investigating the role of confounding by socioeconomic status in the diabetes-cancer relationship.

METHODS: All people in Scotland aged 55-79 years diagnosed with any of the cancers of interest during the period 2001-2007 were identified and classified by the presence/absence of co-morbid type 2 diabetes. The influence of diabetes on cancer risk for each site was assessed via Poisson regression, initially with adjustment for age only, then adjusted for both age and socioeconomic status.

RESULTS: There were 4,285 incident cancers in people with type 2 diabetes. RR for any cancers (adjusted for age only) was 1.11 (95% CI 1.05, 1.17) for men and 1.33 (1.28, 1.40) for women. Corresponding values after additional adjustment for socioeconomic status were 1.10 (1.04, 1.15) and 1.31 (1.25, 1.38), respectively. RRs for individual cancer sites varied markedly.

CONCLUSIONS/INTERPRETATION: Socioeconomic status was found to have little influence on the association between type 2 diabetes and cancer.

Original language	English
Pages (from-to)	1712-1715
Number of pages	4
Journal	Diabetologia
Volume	56
Early online date	10 May 2013
DOIs	https://doi.org/10.1007/s00125-013-2937-6
Publication status	Published - Aug 2013

Bibliographical note

Acknowledgements
This work is presented by the named authors on behalf of all members of the Scottish Diabetes Research Network Epidemiology Group. The data used are available for analysis thanks to the hard work of numerous NHS staff who enter the data, and people and organisations (the Scottish Care Information – Diabetes Collaboration [SCI-DC] Steering Group, the Scottish Diabetes Group, the Scottish Diabetes Survey Monitoring Group, the managed clinical network managers and staff in each Health Board) involved in setting up, maintaining and overseeing SCI-DC. Thanks are due also to staff of the Scottish Cancer Registry and to the Information Services Division (ISD) record linkage team.

Funding
This work was funded by the European Foundation for the Study of Diabetes (grant number 90768) and the Wellcome Trust through the Scottish Health Informatics Programme (SHIP) Grant (grant number WT086113). Funding for diabetes register linkage was provided by the Scottish Government and the authors acknowledge the financial support of NHS Research Scotland (NRS), through the Scottish Diabetes Research Network.

Keywords

Aged
Diabetes Mellitus, Type 2/epidemiology
Female
Humans
Male
Middle Aged
Neoplasms/epidemiology
Scotland/epidemiology
Social Class

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

@article{47d882afc26740fab8f3de80a8d1b4ac,

title = "Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001-2007",

abstract = "AIMS/HYPOTHESIS: The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on the risk of cancer at 16 different sites, while specifically investigating the role of confounding by socioeconomic status in the diabetes-cancer relationship.METHODS: All people in Scotland aged 55-79 years diagnosed with any of the cancers of interest during the period 2001-2007 were identified and classified by the presence/absence of co-morbid type 2 diabetes. The influence of diabetes on cancer risk for each site was assessed via Poisson regression, initially with adjustment for age only, then adjusted for both age and socioeconomic status.RESULTS: There were 4,285 incident cancers in people with type 2 diabetes. RR for any cancers (adjusted for age only) was 1.11 (95% CI 1.05, 1.17) for men and 1.33 (1.28, 1.40) for women. Corresponding values after additional adjustment for socioeconomic status were 1.10 (1.04, 1.15) and 1.31 (1.25, 1.38), respectively. RRs for individual cancer sites varied markedly.CONCLUSIONS/INTERPRETATION: Socioeconomic status was found to have little influence on the association between type 2 diabetes and cancer.",

keywords = "Aged, Diabetes Mellitus, Type 2/epidemiology, Female, Humans, Male, Middle Aged, Neoplasms/epidemiology, Scotland/epidemiology, Social Class",

author = "Walker, {J J} and Brewster, {D H} and Colhoun, {H M} and Fischbacher, {C M} and Leese, {G P} and Lindsay, {R S} and McKnight, {J A} and S Philip and N Sattar and Stockton, {D L} and Wild, {S H} and {Scottish Diabetes Research Network (SDRN) Epidemiology group}",

note = "Acknowledgements This work is presented by the named authors on behalf of all members of the Scottish Diabetes Research Network Epidemiology Group. The data used are available for analysis thanks to the hard work of numerous NHS staff who enter the data, and people and organisations (the Scottish Care Information – Diabetes Collaboration [SCI-DC] Steering Group, the Scottish Diabetes Group, the Scottish Diabetes Survey Monitoring Group, the managed clinical network managers and staff in each Health Board) involved in setting up, maintaining and overseeing SCI-DC. Thanks are due also to staff of the Scottish Cancer Registry and to the Information Services Division (ISD) record linkage team. Funding This work was funded by the European Foundation for the Study of Diabetes (grant number 90768) and the Wellcome Trust through the Scottish Health Informatics Programme (SHIP) Grant (grant number WT086113). Funding for diabetes register linkage was provided by the Scottish Government and the authors acknowledge the financial support of NHS Research Scotland (NRS), through the Scottish Diabetes Research Network.",

year = "2013",

month = aug,

doi = "10.1007/s00125-013-2937-6",

language = "English",

volume = "56",

pages = "1712--1715",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer ",

}

TY - JOUR

T1 - Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001-2007

AU - Walker, J J

AU - Brewster, D H

AU - Colhoun, H M

AU - Fischbacher, C M

AU - Leese, G P

AU - Lindsay, R S

AU - McKnight, J A

AU - Philip, S

AU - Sattar, N

AU - Stockton, D L

AU - Wild, S H

AU - Scottish Diabetes Research Network (SDRN) Epidemiology group

N1 - Acknowledgements This work is presented by the named authors on behalf of all members of the Scottish Diabetes Research Network Epidemiology Group. The data used are available for analysis thanks to the hard work of numerous NHS staff who enter the data, and people and organisations (the Scottish Care Information – Diabetes Collaboration [SCI-DC] Steering Group, the Scottish Diabetes Group, the Scottish Diabetes Survey Monitoring Group, the managed clinical network managers and staff in each Health Board) involved in setting up, maintaining and overseeing SCI-DC. Thanks are due also to staff of the Scottish Cancer Registry and to the Information Services Division (ISD) record linkage team. Funding This work was funded by the European Foundation for the Study of Diabetes (grant number 90768) and the Wellcome Trust through the Scottish Health Informatics Programme (SHIP) Grant (grant number WT086113). Funding for diabetes register linkage was provided by the Scottish Government and the authors acknowledge the financial support of NHS Research Scotland (NRS), through the Scottish Diabetes Research Network.

PY - 2013/8

Y1 - 2013/8

N2 - AIMS/HYPOTHESIS: The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on the risk of cancer at 16 different sites, while specifically investigating the role of confounding by socioeconomic status in the diabetes-cancer relationship.METHODS: All people in Scotland aged 55-79 years diagnosed with any of the cancers of interest during the period 2001-2007 were identified and classified by the presence/absence of co-morbid type 2 diabetes. The influence of diabetes on cancer risk for each site was assessed via Poisson regression, initially with adjustment for age only, then adjusted for both age and socioeconomic status.RESULTS: There were 4,285 incident cancers in people with type 2 diabetes. RR for any cancers (adjusted for age only) was 1.11 (95% CI 1.05, 1.17) for men and 1.33 (1.28, 1.40) for women. Corresponding values after additional adjustment for socioeconomic status were 1.10 (1.04, 1.15) and 1.31 (1.25, 1.38), respectively. RRs for individual cancer sites varied markedly.CONCLUSIONS/INTERPRETATION: Socioeconomic status was found to have little influence on the association between type 2 diabetes and cancer.

AB - AIMS/HYPOTHESIS: The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on the risk of cancer at 16 different sites, while specifically investigating the role of confounding by socioeconomic status in the diabetes-cancer relationship.METHODS: All people in Scotland aged 55-79 years diagnosed with any of the cancers of interest during the period 2001-2007 were identified and classified by the presence/absence of co-morbid type 2 diabetes. The influence of diabetes on cancer risk for each site was assessed via Poisson regression, initially with adjustment for age only, then adjusted for both age and socioeconomic status.RESULTS: There were 4,285 incident cancers in people with type 2 diabetes. RR for any cancers (adjusted for age only) was 1.11 (95% CI 1.05, 1.17) for men and 1.33 (1.28, 1.40) for women. Corresponding values after additional adjustment for socioeconomic status were 1.10 (1.04, 1.15) and 1.31 (1.25, 1.38), respectively. RRs for individual cancer sites varied markedly.CONCLUSIONS/INTERPRETATION: Socioeconomic status was found to have little influence on the association between type 2 diabetes and cancer.

KW - Aged

KW - Diabetes Mellitus, Type 2/epidemiology

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasms/epidemiology

KW - Scotland/epidemiology

KW - Social Class

U2 - 10.1007/s00125-013-2937-6

DO - 10.1007/s00125-013-2937-6

M3 - Article

C2 - 23661106

SN - 0012-186X

VL - 56

SP - 1712

EP - 1715

JO - Diabetologia

JF - Diabetologia

ER -

Type 2 diabetes, socioeconomic status and risk of cancer in Scotland 2001-2007

Abstract

Bibliographical note

Keywords

UN SDGs

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