UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment: Questionnaire and Workshop Proceedings

Aisling McFall, Tuuli M. Hietamies, Ashton Bernard, Margaux Aimable, Stuart M. Allan, Philip M. Bath, Gaia Brezzo, Roxana O. Carare, Hilary V. Carswell, Andrew N. Clarkson, Gillian Currie, Tracy D. Farr, Jill Fowler, Mark Good, Atticus H. Hainsworth, Catherine Hall, Karen Horsburgh, Rajesh Kalaria, Patrick Kehoe, Catherine LawrenceMalcolm Macleod, Alison McNeilly, Alyson A. Miller, Scott Miners, Vincent Mok, Michael O’Sullivan, Bettina Platt, Emily S. Sena, Matthew Sharp, Patrick Strangeward, Stefan Szymkowiak, Rhian M. Touyz, Rebecca C. Trueman, Claire White, Chris McCabe, Lorraine M. Work*, Terence J. Quinn

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, 6 themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured and therefore, that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.
Original languageEnglish
JournalJournal of Cerebral Blood Flow and Metabolism
Publication statusAccepted/In press - 6 Dec 2019

Fingerprint

Blood Vessels
Consensus
Outcome Assessment (Health Care)
Education
Research
Research Personnel
Cognitive Dysfunction
Surveys and Questionnaires

Keywords

  • dementia
  • methodology
  • outcomes
  • questionnaire
  • vascular cognitive impairment

Cite this

McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., ... Quinn, T. J. (Accepted/In press). UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment: Questionnaire and Workshop Proceedings. Journal of Cerebral Blood Flow and Metabolism.

UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment : Questionnaire and Workshop Proceedings. / McFall, Aisling; Hietamies, Tuuli M.; Bernard, Ashton; Aimable, Margaux; Allan, Stuart M.; Bath, Philip M.; Brezzo, Gaia; Carare, Roxana O.; Carswell, Hilary V.; Clarkson, Andrew N.; Currie, Gillian; Farr, Tracy D.; Fowler, Jill; Good, Mark; Hainsworth, Atticus H.; Hall, Catherine; Horsburgh, Karen; Kalaria, Rajesh; Kehoe, Patrick; Lawrence, Catherine; Macleod, Malcolm; McNeilly, Alison; Miller, Alyson A.; Miners, Scott; Mok, Vincent; O’Sullivan, Michael; Platt, Bettina; Sena, Emily S.; Sharp, Matthew; Strangeward, Patrick; Szymkowiak, Stefan; Touyz, Rhian M.; Trueman, Rebecca C.; White, Claire ; McCabe, Chris; Work, Lorraine M. (Corresponding Author); Quinn, Terence J.

In: Journal of Cerebral Blood Flow and Metabolism, 06.12.2019.

Research output: Contribution to journalArticle

McFall, A, Hietamies, TM, Bernard, A, Aimable, M, Allan, SM, Bath, PM, Brezzo, G, Carare, RO, Carswell, HV, Clarkson, AN, Currie, G, Farr, TD, Fowler, J, Good, M, Hainsworth, AH, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, Macleod, M, McNeilly, A, Miller, AA, Miners, S, Mok, V, O’Sullivan, M, Platt, B, Sena, ES, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, RM, Trueman, RC, White, C, McCabe, C, Work, LM & Quinn, TJ 2019, 'UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment: Questionnaire and Workshop Proceedings', Journal of Cerebral Blood Flow and Metabolism.
McFall, Aisling ; Hietamies, Tuuli M. ; Bernard, Ashton ; Aimable, Margaux ; Allan, Stuart M. ; Bath, Philip M. ; Brezzo, Gaia ; Carare, Roxana O. ; Carswell, Hilary V. ; Clarkson, Andrew N. ; Currie, Gillian ; Farr, Tracy D. ; Fowler, Jill ; Good, Mark ; Hainsworth, Atticus H. ; Hall, Catherine ; Horsburgh, Karen ; Kalaria, Rajesh ; Kehoe, Patrick ; Lawrence, Catherine ; Macleod, Malcolm ; McNeilly, Alison ; Miller, Alyson A. ; Miners, Scott ; Mok, Vincent ; O’Sullivan, Michael ; Platt, Bettina ; Sena, Emily S. ; Sharp, Matthew ; Strangeward, Patrick ; Szymkowiak, Stefan ; Touyz, Rhian M. ; Trueman, Rebecca C. ; White, Claire ; McCabe, Chris ; Work, Lorraine M. ; Quinn, Terence J. / UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment : Questionnaire and Workshop Proceedings. In: Journal of Cerebral Blood Flow and Metabolism. 2019.
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abstract = "Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, 6 themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured and therefore, that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.",
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author = "Aisling McFall and Hietamies, {Tuuli M.} and Ashton Bernard and Margaux Aimable and Allan, {Stuart M.} and Bath, {Philip M.} and Gaia Brezzo and Carare, {Roxana O.} and Carswell, {Hilary V.} and Clarkson, {Andrew N.} and Gillian Currie and Farr, {Tracy D.} and Jill Fowler and Mark Good and Hainsworth, {Atticus H.} and Catherine Hall and Karen Horsburgh and Rajesh Kalaria and Patrick Kehoe and Catherine Lawrence and Malcolm Macleod and Alison McNeilly and Miller, {Alyson A.} and Scott Miners and Vincent Mok and Michael O’Sullivan and Bettina Platt and Sena, {Emily S.} and Matthew Sharp and Patrick Strangeward and Stefan Szymkowiak and Touyz, {Rhian M.} and Trueman, {Rebecca C.} and Claire White and Chris McCabe and Work, {Lorraine M.} and Quinn, {Terence J.}",
note = "FUNDING: The workshop was supported through an ARUK Scottish Network small grant. PMB is Stroke Association Professor, Stroke Medicine and a NIHR Senior Investigator. Several of the authors are members of the Dementias Platform UK Vascular experimental medicine group (AHH, KH, RC, RNK, SMA, TJQ). AMcF is supported by a BHF PhD studentship (FS/15/64/32035) and TMH a Cunningham Trust PhD studentship (CU15007.0001). ACKNOWLEDGEMENTS: We are grateful to the Institute of Cardiovascular and Medical Sciences, University of Glasgow for hosting the meeting.",
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T2 - Questionnaire and Workshop Proceedings

AU - McFall, Aisling

AU - Hietamies, Tuuli M.

AU - Bernard, Ashton

AU - Aimable, Margaux

AU - Allan, Stuart M.

AU - Bath, Philip M.

AU - Brezzo, Gaia

AU - Carare, Roxana O.

AU - Carswell, Hilary V.

AU - Clarkson, Andrew N.

AU - Currie, Gillian

AU - Farr, Tracy D.

AU - Fowler, Jill

AU - Good, Mark

AU - Hainsworth, Atticus H.

AU - Hall, Catherine

AU - Horsburgh, Karen

AU - Kalaria, Rajesh

AU - Kehoe, Patrick

AU - Lawrence, Catherine

AU - Macleod, Malcolm

AU - McNeilly, Alison

AU - Miller, Alyson A.

AU - Miners, Scott

AU - Mok, Vincent

AU - O’Sullivan, Michael

AU - Platt, Bettina

AU - Sena, Emily S.

AU - Sharp, Matthew

AU - Strangeward, Patrick

AU - Szymkowiak, Stefan

AU - Touyz, Rhian M.

AU - Trueman, Rebecca C.

AU - White, Claire

AU - McCabe, Chris

AU - Work, Lorraine M.

AU - Quinn, Terence J.

N1 - FUNDING: The workshop was supported through an ARUK Scottish Network small grant. PMB is Stroke Association Professor, Stroke Medicine and a NIHR Senior Investigator. Several of the authors are members of the Dementias Platform UK Vascular experimental medicine group (AHH, KH, RC, RNK, SMA, TJQ). AMcF is supported by a BHF PhD studentship (FS/15/64/32035) and TMH a Cunningham Trust PhD studentship (CU15007.0001). ACKNOWLEDGEMENTS: We are grateful to the Institute of Cardiovascular and Medical Sciences, University of Glasgow for hosting the meeting.

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KW - methodology

KW - outcomes

KW - questionnaire

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JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

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