Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep

David J Carr, Raymond P Aitken, John S Milne, Anna L David, Jacqueline M Wallace

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Our aim was to identify which ultrasound parameters can be most accurately measured and best predict ovine fetal weight in late gestation. Singleton pregnancies were established using embryo transfer in 32 adolescent ewes, which were subsequently overnourished to produce fetuses of variable size (1720–6260 g). Ultrasound measurements at 126–133 days gestation were compared with fetal weight/biometry at late-gestation necropsy (n = 19) or term delivery (n = 13). Abdominal circumference (AC) and renal volume (RV) correlated best with physical measurements (r = 0.78–0.83) and necropsy/birth weight (r = 0.79–0.84). Combination of AC + RV produced an estimated fetal weight equation [Log EFW = 2.115 + 0.003 AC + 0.12 RV – 0.005 RV2] with highest adjusted R2 (0.72) and lowest mean absolute/percentage prediction error (396–550 g/11.1%–13.2%). In conclusion, AC and RV are parameters of choice for assessment of late-gestation ovine fetal growth and can be used to estimate fetal weight with similar accuracy to human fetuses.
Original languageEnglish
Pages (from-to)1588-1595
Number of pages8
JournalUltrasound in Medicine & Biology
Volume37
Issue number10
Early online date6 Aug 2011
DOIs
Publication statusPublished - Oct 2011

Fingerprint

sheep
Fetal Weight
circumferences
Sheep
Pregnancy
Kidney
Growth
fetuses
Fetus
Biometry
Embryo Transfer
embryos
pregnancy
Fetal Development
Birth Weight
delivery
estimates
predictions

Cite this

Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep. / Carr, David J; Aitken, Raymond P; Milne, John S; David, Anna L; Wallace, Jacqueline M.

In: Ultrasound in Medicine & Biology, Vol. 37, No. 10, 10.2011, p. 1588-1595.

Research output: Contribution to journal › Article

Carr, DJ, Aitken, RP, Milne, JS, David, AL & Wallace, JM 2011, 'Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep' Ultrasound in Medicine & Biology, vol. 37, no. 10, pp. 1588-1595. https://doi.org/10.1016/j.ultrasmedbio.2011.06.016
Carr DJ, Aitken RP, Milne JS, David AL, Wallace JM. Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep. Ultrasound in Medicine & Biology. 2011 Oct;37(10):1588-1595. https://doi.org/10.1016/j.ultrasmedbio.2011.06.016
Carr, David J ; Aitken, Raymond P ; Milne, John S ; David, Anna L ; Wallace, Jacqueline M. / Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep. In: Ultrasound in Medicine & Biology. 2011 ; Vol. 37, No. 10. pp. 1588-1595.
@article{92e73e755e7046ae99ed923f985b148b,
title = "Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep",
abstract = "Our aim was to identify which ultrasound parameters can be most accurately measured and best predict ovine fetal weight in late gestation. Singleton pregnancies were established using embryo transfer in 32 adolescent ewes, which were subsequently overnourished to produce fetuses of variable size (1720–6260 g). Ultrasound measurements at 126–133 days gestation were compared with fetal weight/biometry at late-gestation necropsy (n = 19) or term delivery (n = 13). Abdominal circumference (AC) and renal volume (RV) correlated best with physical measurements (r = 0.78–0.83) and necropsy/birth weight (r = 0.79–0.84). Combination of AC + RV produced an estimated fetal weight equation [Log EFW = 2.115 + 0.003 AC + 0.12 RV – 0.005 RV2] with highest adjusted R2 (0.72) and lowest mean absolute/percentage prediction error (396–550 g/11.1{\%}–13.2{\%}). In conclusion, AC and RV are parameters of choice for assessment of late-gestation ovine fetal growth and can be used to estimate fetal weight with similar accuracy to human fetuses.",
author = "Carr, {David J} and Aitken, {Raymond P} and Milne, {John S} and David, {Anna L} and Wallace, {Jacqueline M}",
year = "2011",
month = "10",
doi = "10.1016/j.ultrasmedbio.2011.06.016",
language = "English",
volume = "37",
pages = "1588--1595",
journal = "Ultrasound in Medicine & Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep

AU - Carr, David J

AU - Aitken, Raymond P

AU - Milne, John S

AU - David, Anna L

AU - Wallace, Jacqueline M

PY - 2011/10

Y1 - 2011/10

N2 - Our aim was to identify which ultrasound parameters can be most accurately measured and best predict ovine fetal weight in late gestation. Singleton pregnancies were established using embryo transfer in 32 adolescent ewes, which were subsequently overnourished to produce fetuses of variable size (1720–6260 g). Ultrasound measurements at 126–133 days gestation were compared with fetal weight/biometry at late-gestation necropsy (n = 19) or term delivery (n = 13). Abdominal circumference (AC) and renal volume (RV) correlated best with physical measurements (r = 0.78–0.83) and necropsy/birth weight (r = 0.79–0.84). Combination of AC + RV produced an estimated fetal weight equation [Log EFW = 2.115 + 0.003 AC + 0.12 RV – 0.005 RV2] with highest adjusted R2 (0.72) and lowest mean absolute/percentage prediction error (396–550 g/11.1%–13.2%). In conclusion, AC and RV are parameters of choice for assessment of late-gestation ovine fetal growth and can be used to estimate fetal weight with similar accuracy to human fetuses.

AB - Our aim was to identify which ultrasound parameters can be most accurately measured and best predict ovine fetal weight in late gestation. Singleton pregnancies were established using embryo transfer in 32 adolescent ewes, which were subsequently overnourished to produce fetuses of variable size (1720–6260 g). Ultrasound measurements at 126–133 days gestation were compared with fetal weight/biometry at late-gestation necropsy (n = 19) or term delivery (n = 13). Abdominal circumference (AC) and renal volume (RV) correlated best with physical measurements (r = 0.78–0.83) and necropsy/birth weight (r = 0.79–0.84). Combination of AC + RV produced an estimated fetal weight equation [Log EFW = 2.115 + 0.003 AC + 0.12 RV – 0.005 RV2] with highest adjusted R2 (0.72) and lowest mean absolute/percentage prediction error (396–550 g/11.1%–13.2%). In conclusion, AC and RV are parameters of choice for assessment of late-gestation ovine fetal growth and can be used to estimate fetal weight with similar accuracy to human fetuses.

U2 - 10.1016/j.ultrasmedbio.2011.06.016

DO - 10.1016/j.ultrasmedbio.2011.06.016

M3 - Article

VL - 37

SP - 1588

EP - 1595

JO - Ultrasound in Medicine & Biology

JF - Ultrasound in Medicine & Biology

SN - 0301-5629

IS - 10

ER -

Access to Document