In this article, we describe the mechanisms by which morphogens in the Xenopus embryo exert their long-range effects. Our results are consistent with the idea that signalling molecules such as activin and the nodal-related proteins traverse responding tissue not by transcytosis or by cytonemes but by movement through the extracellular space. We suggest, however, that additional experiments, involving real-time imaging of morphogens, are required for a real understanding of what influences signalling range and the shape of a morphogen gradient.
|Number of pages||6|
|Journal||Philosophical Transactions of the Royal Society of London. Series B: Biological sciences|
|Publication status||Published - 12 Apr 2008|
- Embryonic Induction
- Signal Transduction
Smith, J. C., Hagemann, A., Saka, Y., & Williams, P. H. (2008). Understanding how morphogens work. Philosophical Transactions of the Royal Society of London. Series B: Biological sciences, 363(1495), 1387-1392. https://doi.org/10.1098/rstb.2007.2256