Understanding how morphogens work

J C Smith, A Hagemann, Yasushi Saka, P H Williams

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this article, we describe the mechanisms by which morphogens in the Xenopus embryo exert their long-range effects. Our results are consistent with the idea that signalling molecules such as activin and the nodal-related proteins traverse responding tissue not by transcytosis or by cytonemes but by movement through the extracellular space. We suggest, however, that additional experiments, involving real-time imaging of morphogens, are required for a real understanding of what influences signalling range and the shape of a morphogen gradient.
Original languageEnglish
Pages (from-to)1387-1392
Number of pages6
JournalPhilosophical Transactions of the Royal Society of London. Series B: Biological sciences
Volume363
Issue number1495
DOIs
Publication statusPublished - 12 Apr 2008

Fingerprint

Nodal Protein
Transcytosis
Activins
Extracellular Space
Xenopus
Embryonic Structures

Keywords

  • Activins
  • Animals
  • Embryonic Induction
  • Morphogenesis
  • Signal Transduction
  • Xenopus

Cite this

Understanding how morphogens work. / Smith, J C; Hagemann, A; Saka, Yasushi; Williams, P H.

In: Philosophical Transactions of the Royal Society of London. Series B: Biological sciences, Vol. 363, No. 1495, 12.04.2008, p. 1387-1392.

Research output: Contribution to journalArticle

Smith, J C ; Hagemann, A ; Saka, Yasushi ; Williams, P H. / Understanding how morphogens work. In: Philosophical Transactions of the Royal Society of London. Series B: Biological sciences. 2008 ; Vol. 363, No. 1495. pp. 1387-1392.
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