In the enantioselective hydrogenation of ethyl pyruvate using hydroquinidine 4-chlorobenzoate modified Pt/gamma-Al2O3 catalyst, the sense of the enantioselectivity is a function of the modifier concentration. At low concentration (S)-ethyl lactate is preferred and at higher concentration (R)-ethyl lactate is formed; the opposite trend is observed with hydroquinine 4-chlorobenzoate. This is the first example where enantio-inversion is induced solely as a function of the chiral modifier concentration.
- enantioselective hydrogenation
- ethyl pyruvate hydrogenation