Universal enantioselective discrimination by Raman spectroscopy

Johannes Kiefer, Kristina Noack

Research output: Contribution to journalArticle

15 Citations (Scopus)
6 Downloads (Pure)

Abstract

Distinguishing between the enantiomers of chiral substances and their quantification is an analytical challenge, in particular in the pharmaceutical and biochemical sectors. A Raman spectroscopic method for discrimination of enantiomers is proposed. Advantage is taken of the polarization properties when Raman scattering occurs in an optically active medium. It is shown that a conventional polarization-resolved Raman setup leads to identical spectra of the two enantiomers. However, inserting a half-wave retarder to rotate the signal polarization by a fixed angle enables the efficient and universal enantiomeric discrimination. Hence, the applicability of any polarization-resolved Raman experiment can be improved substantially without significant modification of the setup or the use of chiral labeling or the addition of a substrate for selective plasmonic enhancement. In principle, the proposed technique allows simultaneous speciation, enantiomeric discrimination, as well as structural and quantitative analysis.
Original languageEnglish
Pages (from-to)1787-1790
Number of pages4
JournalAnalyst
Volume140
Issue number6
Early online date28 Jan 2015
DOIs
Publication statusPublished - 21 Mar 2015

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Raman Spectrum Analysis
Raman spectroscopy
Enantiomers
polarization
Polarization
Pharmaceutical Preparations
structural analysis
Structural analysis
Drug products
Labeling
quantitative analysis
Raman scattering
drug
scattering
substrate
Substrates
Chemical analysis
experiment
Experiments

Cite this

Universal enantioselective discrimination by Raman spectroscopy. / Kiefer, Johannes; Noack, Kristina.

In: Analyst, Vol. 140, No. 6, 21.03.2015, p. 1787-1790.

Research output: Contribution to journalArticle

Kiefer, Johannes ; Noack, Kristina. / Universal enantioselective discrimination by Raman spectroscopy. In: Analyst. 2015 ; Vol. 140, No. 6. pp. 1787-1790.
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