Uptake of glucose analogues by colonic tumour cells during growth and after treatment with hydroxyurea

Timothy Andrew Davies Smith, Jenny Titley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

SW620 cells were grown in tissue culture flasks to various cell densities producing populations of cells with a range of proliferative indices. The uptake of the two glucose analogues, deoxy-d-glucose (DG) and 3-O-methylglucose (OMG) was determined and found to be associated with S-phase fraction. The strong correlation between DG and OMG uptakes suggested that proliferation-related changes in transmembrane transport accounted for the association with S-phase fraction. Treatment of SW620 cells with the cell cycle inhibitor hydroxyurea was found to increase the uptake of DG and OMG in a time-dependent manner.
Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalCancer Letters
Volume141
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 1999

Keywords

  • tumour
  • proliferation
  • hydroxyurea
  • deoxyglucose

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