Use of ovary culture techniques in reproductive toxicology

Agnes Stefansdottir, Paul A Fowler, Nicola Powles-Glover, Richard A Anderson, Norah Spears

Research output: Contribution to journalLiterature review

23 Citations (Scopus)
5 Downloads (Pure)

Abstract

There is increasing evidence to indicate that a substantial number of both man-made and naturally occurring chemicals are disruptive to human and wildlife reproductive health. Currently, reproductive toxicology testing is primarily carried out in vivo, however, in the past 50 years, various culture methods have been developed with the aim of growing ovarian follicles in vitro. These culture systems have become a widely used tool in reproductive biology and toxicology. In this review we describe how reproductive toxicology of the ovary is greatly enhanced by in vitro studies. Experiments using in vitro ovarian cultures to understand or detect damage to the ovary itself and to its specialised structures of the follicles and oocytes, allows for faster screening of potential developmental and/or reproductive toxicants.

Original languageEnglish
Pages (from-to)117-135
Number of pages19
JournalReproductive Toxicology
Volume49
Early online date19 Aug 2014
DOIs
Publication statusPublished - Nov 2014

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Keywords

  • ovary
  • follicle
  • tissue culture
  • in vitro
  • toxicology
  • pharmaceutical
  • EDC

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