Use of Polyamine Transport System by Polyamine Anthracene Conjugates in Human Leukaemic Cells

R. A. Ghani, H. M. Wallace, O. V. Phanstiel

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Abstract

Background

It is well known that cancer cells have increased polyamine concentrations compared with normal cells. This relation is due to a combination of increased polyamine uptake via the polyamine transport system (PTS) as well as increased biosynthesis. Thus, we may be able to exploit the PTS for selective delivery of cytotoxic agents to cancer cells by attaching them to polyamine vectors. Such an approach should reduce non-specific toxicities and therefore decrease the side-effects associated with chemotherapy. This concept is also supported by the nature of PTS, which can accommodate a wide range of substrates. Three compounds combining the DNA intercalator, anthracene, with a polyamine side chain have been synthesised: Ant 4, Ant 44, and Ant 444.The aim of this study was to investigate the mode of cell death induced by anthracene conjugates in HL-60 cell lines.
Original languageEnglish
Article numberP0200
Pages (from-to)E64-E65
Number of pages2
JournalEuropean Journal of Cancer
Volume50
Issue numberSuppl 4
DOIs
Publication statusPublished - May 2014
Event6th Asian Oncology Summit and 10th Annual Conference of the Organisation for Oncology and Translational Research - Kuala Lumpur, Malaysia
Duration: 11 Apr 201413 Apr 2014

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