Use of Polyamine Transport System by Polyamine Anthracene Conjugates in Human Leukaemic Cells

R. A. Ghani; H. M. Wallace; O. V. Phanstiel

doi:10.1016/j.ejca.2014.03.244

Abstract

Background

It is well known that cancer cells have increased polyamine concentrations compared with normal cells. This relation is due to a combination of increased polyamine uptake via the polyamine transport system (PTS) as well as increased biosynthesis. Thus, we may be able to exploit the PTS for selective delivery of cytotoxic agents to cancer cells by attaching them to polyamine vectors. Such an approach should reduce non-specific toxicities and therefore decrease the side-effects associated with chemotherapy. This concept is also supported by the nature of PTS, which can accommodate a wide range of substrates. Three compounds combining the DNA intercalator, anthracene, with a polyamine side chain have been synthesised: Ant 4, Ant 44, and Ant 444.The aim of this study was to investigate the mode of cell death induced by anthracene conjugates in HL-60 cell lines.

Original language	English
Article number	P0200
Pages (from-to)	E64-E65
Number of pages	2
Journal	European Journal of Cancer
Volume	50
Issue number	Suppl 4
DOIs	https://doi.org/10.1016/j.ejca.2014.03.244
Publication status	Published - May 2014
Event	6th Asian Oncology Summit and 10th Annual Conference of the Organisation for Oncology and Translational Research - Kuala Lumpur, Malaysia Duration: 11 Apr 2014 → 13 Apr 2014

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title = "Use of Polyamine Transport System by Polyamine Anthracene Conjugates in Human Leukaemic Cells",

abstract = "BackgroundIt is well known that cancer cells have increased polyamine concentrations compared with normal cells. This relation is due to a combination of increased polyamine uptake via the polyamine transport system (PTS) as well as increased biosynthesis. Thus, we may be able to exploit the PTS for selective delivery of cytotoxic agents to cancer cells by attaching them to polyamine vectors. Such an approach should reduce non-specific toxicities and therefore decrease the side-effects associated with chemotherapy. This concept is also supported by the nature of PTS, which can accommodate a wide range of substrates. Three compounds combining the DNA intercalator, anthracene, with a polyamine side chain have been synthesised: Ant 4, Ant 44, and Ant 444.The aim of this study was to investigate the mode of cell death induced by anthracene conjugates in HL-60 cell lines.",

author = "Ghani, {R. A.} and Wallace, {H. M.} and Phanstiel, {O. V.}",

year = "2014",

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doi = "10.1016/j.ejca.2014.03.244",

language = "English",

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pages = "E64--E65",

journal = "European Journal of Cancer",

issn = "0959-8049",

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TY - JOUR

T1 - Use of Polyamine Transport System by Polyamine Anthracene Conjugates in Human Leukaemic Cells

AU - Ghani, R. A.

AU - Wallace, H. M.

AU - Phanstiel, O. V.

PY - 2014/5

Y1 - 2014/5

N2 - BackgroundIt is well known that cancer cells have increased polyamine concentrations compared with normal cells. This relation is due to a combination of increased polyamine uptake via the polyamine transport system (PTS) as well as increased biosynthesis. Thus, we may be able to exploit the PTS for selective delivery of cytotoxic agents to cancer cells by attaching them to polyamine vectors. Such an approach should reduce non-specific toxicities and therefore decrease the side-effects associated with chemotherapy. This concept is also supported by the nature of PTS, which can accommodate a wide range of substrates. Three compounds combining the DNA intercalator, anthracene, with a polyamine side chain have been synthesised: Ant 4, Ant 44, and Ant 444.The aim of this study was to investigate the mode of cell death induced by anthracene conjugates in HL-60 cell lines.

AB - BackgroundIt is well known that cancer cells have increased polyamine concentrations compared with normal cells. This relation is due to a combination of increased polyamine uptake via the polyamine transport system (PTS) as well as increased biosynthesis. Thus, we may be able to exploit the PTS for selective delivery of cytotoxic agents to cancer cells by attaching them to polyamine vectors. Such an approach should reduce non-specific toxicities and therefore decrease the side-effects associated with chemotherapy. This concept is also supported by the nature of PTS, which can accommodate a wide range of substrates. Three compounds combining the DNA intercalator, anthracene, with a polyamine side chain have been synthesised: Ant 4, Ant 44, and Ant 444.The aim of this study was to investigate the mode of cell death induced by anthracene conjugates in HL-60 cell lines.

U2 - 10.1016/j.ejca.2014.03.244

DO - 10.1016/j.ejca.2014.03.244

M3 - Abstract

SN - 0959-8049

VL - 50

SP - E64-E65

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - Suppl 4

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T2 - 6th Asian Oncology Summit and 10th Annual Conference of the Organisation for Oncology and Translational Research

Y2 - 11 April 2014 through 13 April 2014

ER -

Use of Polyamine Transport System by Polyamine Anthracene Conjugates in Human Leukaemic Cells

Abstract

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