Utility of B-type Natriuretic Peptide in Predicting Medium-Term Mortality in Patients Undergoing Major Non-Cardiac Surgery

Brian Cuthbertson, Amir R. Amiri, Bernard Lewis Croal, Sriram Rajagopalan, Julie Brittenden, Graham Hillis

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28 Citations (Scopus)


This study was conducted to assess the ability of preoperative B-type natriuretic peptide levels to predict medium-term mortality in patients who undergo major noncardiac surgery. During a median of 654 days of follow-up, 33 patients from a total cohort of 204 patients (16%) died, 17 from cardiovascular causes. The optimal cutoff in this cohort, determined using a receiver-operating characteristic curve, was >35 pg ml(-1). This was associated with a 3.5-fold increase in the hazard of death (p = 0.001) and a 6.9-fold increase in the hazard of cardiovascular mortality (p = 0.003). In conclusion, these findings extend recent work demonstrating that B-type natriuretic peptide levels obtained before major noncardiac surgery can be used to predict perioperative morbidity and indicate that they also forecast medium-term mortality, particularly cardiovascular death.

Original languageEnglish
Pages (from-to)1310-1313
Number of pages4
JournalThe American Journal of Cardiology
Issue number8
Early online date25 Jul 2007
Publication statusPublished - 15 Oct 2007


  • cardiac risk
  • vascular-surgery
  • association
  • troponin
  • assay

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