Utility of B-type Natriuretic Peptide in Predicting Medium-Term Mortality in Patients Undergoing Major Non-Cardiac Surgery

Brian Cuthbertson, Amir R. Amiri, Bernard Lewis Croal, Sriram Rajagopalan, Julie Brittenden, Graham Hillis

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study was conducted to assess the ability of preoperative B-type natriuretic peptide levels to predict medium-term mortality in patients who undergo major noncardiac surgery. During a median of 654 days of follow-up, 33 patients from a total cohort of 204 patients (16%) died, 17 from cardiovascular causes. The optimal cutoff in this cohort, determined using a receiver-operating characteristic curve, was >35 pg ml(-1). This was associated with a 3.5-fold increase in the hazard of death (p = 0.001) and a 6.9-fold increase in the hazard of cardiovascular mortality (p = 0.003). In conclusion, these findings extend recent work demonstrating that B-type natriuretic peptide levels obtained before major noncardiac surgery can be used to predict perioperative morbidity and indicate that they also forecast medium-term mortality, particularly cardiovascular death.

Original languageEnglish
Pages (from-to)1310-1313
Number of pages4
JournalThe American Journal of Cardiology
Volume100
Issue number8
Early online date25 Jul 2007
DOIs
Publication statusPublished - 15 Oct 2007

Keywords

  • cardiac risk
  • vascular-surgery
  • association
  • troponin
  • assay

Cite this

Utility of B-type Natriuretic Peptide in Predicting Medium-Term Mortality in Patients Undergoing Major Non-Cardiac Surgery. / Cuthbertson, Brian; Amiri, Amir R.; Croal, Bernard Lewis; Rajagopalan, Sriram; Brittenden, Julie; Hillis, Graham.

In: The American Journal of Cardiology, Vol. 100, No. 8, 15.10.2007, p. 1310-1313.

Research output: Contribution to journalArticle

Cuthbertson, Brian ; Amiri, Amir R. ; Croal, Bernard Lewis ; Rajagopalan, Sriram ; Brittenden, Julie ; Hillis, Graham. / Utility of B-type Natriuretic Peptide in Predicting Medium-Term Mortality in Patients Undergoing Major Non-Cardiac Surgery. In: The American Journal of Cardiology. 2007 ; Vol. 100, No. 8. pp. 1310-1313.
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