Vaccination strategies and IgM responses against PKD in rainbow trout

Research output: Contribution to journalAbstract

Abstract

PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.


Copyright © 2019 Published by Elsevier Ltd.
Original languageEnglish
Pages (from-to)423
Number of pages1
JournalFish & Shellfish Immunology
Volume91
Early online date17 Jun 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • vaccination
  • myxozoan
  • parasite
  • antigen
  • igm response

Cite this

Vaccination strategies and IgM responses against PKD in rainbow trout. / Faber, M. N.; Holland, J. W.; Secombes, C. J.

In: Fish & Shellfish Immunology, Vol. 91, 08.2019, p. 423.

Research output: Contribution to journalAbstract

@article{cd41015fb07a48e4bc00948c7338b202,
title = "Vaccination strategies and IgM responses against PKD in rainbow trout",
abstract = "PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.Copyright {\circledC} 2019 Published by Elsevier Ltd.",
keywords = "vaccination, myxozoan, parasite, antigen, igm response",
author = "Faber, {M. N.} and Holland, {J. W.} and Secombes, {C. J.}",
year = "2019",
month = "8",
doi = "10.1016/j.fsi.2019.04.159",
language = "English",
volume = "91",
pages = "423",
journal = "Fish & Shellfish Immunology",
issn = "1050-4648",
publisher = "ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD",

}

TY - JOUR

T1 - Vaccination strategies and IgM responses against PKD in rainbow trout

AU - Faber, M. N.

AU - Holland, J. W.

AU - Secombes, C. J.

PY - 2019/8

Y1 - 2019/8

N2 - PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.Copyright © 2019 Published by Elsevier Ltd.

AB - PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.Copyright © 2019 Published by Elsevier Ltd.

KW - vaccination

KW - myxozoan

KW - parasite

KW - antigen

KW - igm response

UR - http://www.mendeley.com/research/vaccination-strategies-igm-responses-against-pkd-rainbow-trout

U2 - 10.1016/j.fsi.2019.04.159

DO - 10.1016/j.fsi.2019.04.159

M3 - Abstract

VL - 91

SP - 423

JO - Fish & Shellfish Immunology

JF - Fish & Shellfish Immunology

SN - 1050-4648

ER -