Vaccination strategies and IgM responses against PKD in rainbow trout

M. N. Faber, J. W. Holland, C. J. Secombes

Research output: Contribution to journalAbstract

Abstract

PKD is one of the most serious diseases affecting trout aquaculture in the UK. Caused by the myxozoan parasite, Tetracapsuloides bryosalmonae, PKD is elicited by the temperature-dependent development of parasite spore sacs in colonial bryozoans. Since recovered fish are known to exhibit protective immunity to re-infection, a successful treatment, based on the reduction of kidney pathology and parasite burden, could markedly reduce fish mortalities leading to improved productivity and fish welfare. Our investigations have focused on the selection of putative T. bryosalmonae virulence factors to unravel host immune evasion mechanisms exploited by the parasite, whilst shortlisting candidates for vaccine studies.


Copyright © 2019 Published by Elsevier Ltd.
Original languageEnglish
Pages (from-to)423
Number of pages1
JournalFish & Shellfish Immunology
Volume91
Early online date17 Jun 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • vaccination
  • myxozoan
  • parasite
  • antigen
  • igm response

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