Validation and inter-laboratory study of selective hydride generation for fast screening of inorganic arsenic in seafood

Karel Marschner, Ásta H. Pétursdóttir, Patrick Bücker, Andrea Raab, Jörg Feldmann, Zoltán Mester, Tomáš Matoušek, Stanislav Musil* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It is advisable to monitor and regulate inorganic arsenic (iAs) in food and feedstuff. This work describes an update and validation of a method of selective hydride generation (HG) with inductively coupled plasma mass spectrometry (ICP-MS) for high-throughput screening of iAs content in seafood samples after microwave-assisted extraction with diluted nitric acid and hydrogen peroxide. High concentration of HCl (8 M) for HG along with hydrogen peroxide in samples of a same concentration as used for extraction leads to a selective conversion of iAs to volatile arsine that is released and transported to the detector. A minor contribution from methylarsonate (≈20% to iAs) was found, while HG from dimethylarsinate, trimethylarsine oxide is substantially suppressed (less than 1% to iAs). Methodology was applied to Certified Reference Materials (CRMs) TORT-3, DORM-3, DORM-4, DOLT-4, DOLT-5, PRON-1, SQID-1 and ERM-CE278k, in some of them iAs has been determined for the first time, and to various seaweed samples from a local store. The results were always compared with a reference method and selectivity of iAs determination was evaluated. An inter-laboratory reproducibility was tested by comparative analyses of six fish and four seaweed samples in three European laboratories, with good agreement of the results. The method of HG-ICP-MS is sensitive (limit of detection 2 μg kg−1 iAs), well suited for screening of large number of samples and selective at iAs concentration levels at which maximum limits are expected to be set into EU legislation for marine samples.

Original languageEnglish
Pages (from-to)20-28
Number of pages9
JournalAnalytica Chimica Acta
Volume1049
Early online date20 Nov 2018
DOIs
Publication statusPublished - 21 Feb 2019

Fingerprint

Seafood
seafood
Arsenic
Hydrides
arsenic
Screening
Seaweed
Inductively coupled plasma mass spectrometry
seaweed
hydrogen peroxide
Hydrogen Peroxide
Mass Spectrometry
mass spectrometry
Cacodylic Acid
screening
laboratory
plasma
Nitric Acid
Legal Liability
Microwaves

Keywords

  • Certified reference materials
  • Inductively coupled plasma mass spectrometry
  • Inorganic arsenic
  • Interlaboratory comparison
  • Selective hydride generation
  • Speciation analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

Cite this

Validation and inter-laboratory study of selective hydride generation for fast screening of inorganic arsenic in seafood. / Marschner, Karel; Pétursdóttir, Ásta H.; Bücker, Patrick; Raab, Andrea; Feldmann, Jörg; Mester, Zoltán; Matoušek, Tomáš; Musil, Stanislav (Corresponding Author).

In: Analytica Chimica Acta, Vol. 1049, 21.02.2019, p. 20-28.

Research output: Contribution to journalArticle

Marschner, Karel ; Pétursdóttir, Ásta H. ; Bücker, Patrick ; Raab, Andrea ; Feldmann, Jörg ; Mester, Zoltán ; Matoušek, Tomáš ; Musil, Stanislav. / Validation and inter-laboratory study of selective hydride generation for fast screening of inorganic arsenic in seafood. In: Analytica Chimica Acta. 2019 ; Vol. 1049. pp. 20-28.
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