Abstract
Aim: To evaluate the responsiveness of the Vision core module 1 ( VCM1) vision-related quality of life ( VR-QOL) questionnaire to changes in visual acuity in patients with posterior and intermediate uveitis and to validate its use as a clinical end point in uveitis.
Methods: Logarithm of the minimum angle of resolution visual acuity and VR-QOL using the VCM1 questionnaire were prospectively recorded in 37 patients with active posterior segment intraocular inflammation before starting systemic immunosuppression with ciclosporin, tacrolimus or the antitumour necrosis factor ( TNF) agent, p55TNFr-Ig, and again 3 months later. Spearman analysis was used to correlate improvements in visual acuity and VR-QOL between baseline and 3 months.
Results: The correlation between changes in visual acuity and VR-QOL was moderate to good for the worse eye ( r = 0.47, p = 0.003), but poor for the better eye ( r = -0.05, p = 0.91). The responsiveness indices effect size and standardised response mean were 0.57 and 0.59, respectively, showing that the VCM1 questionnaire is moderately responsive to immunsosuppressive therapy for active uveitis.
Conclusion: Changes in VR-QOL measured with the VCM1 questionnaire correlated moderately well with changes in the worse eye visual acuity, suggesting that the VCM1 is a valid instrument for monitoring response to treatment in uveitis.
Original language | English |
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Pages (from-to) | 154-156 |
Number of pages | 3 |
Journal | British Journal of Ophthalmology |
Volume | 91 |
Issue number | 2 |
Early online date | 14 Sept 2006 |
DOIs | |
Publication status | Published - Feb 2007 |
Keywords
- visual function
- general health
- therapy