Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children

Steve Turner, Ben Francis, Nuha Wani, Susanne Vijverberg, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Colin Palmer, Esteban G. Burchard, Simon Kebede Merid, Erik Melén, Anke H. Maitland-van der Zee, Pharmacogenomics in Childhood Asthma Consortium

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Downloads (Pure)

Abstract

Our hypothesis was that children with mutations in genes coding for Glutathione S-transferases (GST) have worse asthma outcomes compared to children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were non-significant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.
Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalPharmacogenomics
Volume19
Issue number8
Early online date22 May 2018
DOIs
Publication statusPublished - Jun 2018

Fingerprint

Glutathione Transferase
Asthma
Genotype
Genes
Single Nucleotide Polymorphism
Outcome Assessment (Health Care)
Mutation
Population

Keywords

  • asthma
  • child
  • exacerbation
  • glutathione S-transferase
  • severity
  • tobacco smoke

Cite this

Turner, S., Francis, B., Wani, N., Vijverberg, S., Pino-Yanes, M., Mukhopadhyay, S., ... Pharmacogenomics in Childhood Asthma Consortium (2018). Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children. Pharmacogenomics, 19(8), 707-713. https://doi.org/10.2217/pgs-2018-0027

Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children. / Turner, Steve; Francis, Ben; Wani, Nuha; Vijverberg, Susanne; Pino-Yanes, Maria; Mukhopadhyay, Somnath; Tavendale, Roger; Palmer, Colin; Burchard, Esteban G.; Merid, Simon Kebede; Melén, Erik; Maitland-van der Zee, Anke H.; Pharmacogenomics in Childhood Asthma Consortium.

In: Pharmacogenomics, Vol. 19, No. 8, 06.2018, p. 707-713.

Research output: Contribution to journalArticle

Turner, S, Francis, B, Wani, N, Vijverberg, S, Pino-Yanes, M, Mukhopadhyay, S, Tavendale, R, Palmer, C, Burchard, EG, Merid, SK, Melén, E, Maitland-van der Zee, AH & Pharmacogenomics in Childhood Asthma Consortium 2018, 'Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children', Pharmacogenomics, vol. 19, no. 8, pp. 707-713. https://doi.org/10.2217/pgs-2018-0027
Turner S, Francis B, Wani N, Vijverberg S, Pino-Yanes M, Mukhopadhyay S et al. Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children. Pharmacogenomics. 2018 Jun;19(8):707-713. https://doi.org/10.2217/pgs-2018-0027
Turner, Steve ; Francis, Ben ; Wani, Nuha ; Vijverberg, Susanne ; Pino-Yanes, Maria ; Mukhopadhyay, Somnath ; Tavendale, Roger ; Palmer, Colin ; Burchard, Esteban G. ; Merid, Simon Kebede ; Melén, Erik ; Maitland-van der Zee, Anke H. ; Pharmacogenomics in Childhood Asthma Consortium. / Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children. In: Pharmacogenomics. 2018 ; Vol. 19, No. 8. pp. 707-713.
@article{b659e424c94642f5afb04311bb7afa06,
title = "Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children",
abstract = "Our hypothesis was that children with mutations in genes coding for Glutathione S-transferases (GST) have worse asthma outcomes compared to children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were non-significant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.",
keywords = "asthma, child, exacerbation, glutathione S-transferase, severity, tobacco smoke",
author = "Steve Turner and Ben Francis and Nuha Wani and Susanne Vijverberg and Maria Pino-Yanes and Somnath Mukhopadhyay and Roger Tavendale and Colin Palmer and Burchard, {Esteban G.} and Merid, {Simon Kebede} and Erik Mel{\'e}n and {Maitland-van der Zee}, {Anke H.} and {Pharmacogenomics in Childhood Asthma Consortium}",
note = "AH Maitland-van der Zee received an unrestricted research grant for research on Pharmacogenomics in childhood asthma from Glaxo Smith Kleine. The contribution from GALA II to this work wassupported by grants from NIH to EG Burchard: The National Heart, Lung and Blood Institute (HL088133, HL078885, HL004464, HL104608 and HL117004); the National Institute of Environmental Health Sciences (ES015794); the National Institute on Minority Health and Health Disparities (MD006902); the National Institute of General Medical Sciences (GM007546). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",
year = "2018",
month = "6",
doi = "10.2217/pgs-2018-0027",
language = "English",
volume = "19",
pages = "707--713",
journal = "Pharmacogenomics",
issn = "1744-8042",
publisher = "Future Science",
number = "8",

}

TY - JOUR

T1 - Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children

AU - Turner, Steve

AU - Francis, Ben

AU - Wani, Nuha

AU - Vijverberg, Susanne

AU - Pino-Yanes, Maria

AU - Mukhopadhyay, Somnath

AU - Tavendale, Roger

AU - Palmer, Colin

AU - Burchard, Esteban G.

AU - Merid, Simon Kebede

AU - Melén, Erik

AU - Maitland-van der Zee, Anke H.

AU - Pharmacogenomics in Childhood Asthma Consortium

N1 - AH Maitland-van der Zee received an unrestricted research grant for research on Pharmacogenomics in childhood asthma from Glaxo Smith Kleine. The contribution from GALA II to this work wassupported by grants from NIH to EG Burchard: The National Heart, Lung and Blood Institute (HL088133, HL078885, HL004464, HL104608 and HL117004); the National Institute of Environmental Health Sciences (ES015794); the National Institute on Minority Health and Health Disparities (MD006902); the National Institute of General Medical Sciences (GM007546). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2018/6

Y1 - 2018/6

N2 - Our hypothesis was that children with mutations in genes coding for Glutathione S-transferases (GST) have worse asthma outcomes compared to children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were non-significant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

AB - Our hypothesis was that children with mutations in genes coding for Glutathione S-transferases (GST) have worse asthma outcomes compared to children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were non-significant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

KW - asthma

KW - child

KW - exacerbation

KW - glutathione S-transferase

KW - severity

KW - tobacco smoke

UR - https://www.futuremedicine.com/authorguide/archivesharearticle

U2 - 10.2217/pgs-2018-0027

DO - 10.2217/pgs-2018-0027

M3 - Article

VL - 19

SP - 707

EP - 713

JO - Pharmacogenomics

JF - Pharmacogenomics

SN - 1744-8042

IS - 8

ER -