Variants in genes coding for Glutathione S-Transferases and asthma outcomes in children

Steve Turner, Ben Francis, Nuha Wani, Susanne Vijverberg, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Colin Palmer, Esteban G. Burchard, Simon Kebede Merid, Erik Melén, Anke H. Maitland-van der Zee, Pharmacogenomics in Childhood Asthma Consortium

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Abstract

Our hypothesis was that children with mutations in genes coding for Glutathione S-transferases (GST) have worse asthma outcomes compared to children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were non-significant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.
Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalPharmacogenomics
Volume19
Issue number8
Early online date22 May 2018
DOIs
Publication statusPublished - Jun 2018

Keywords

  • asthma
  • child
  • exacerbation
  • glutathione S-transferase
  • severity
  • tobacco smoke

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