Variation at the GABAA receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K. Green, Detelina Grozeva, Valentina Moskvina, Marian L. Hamshere, Ian R. Jones, Lisa Jones, Liz Forty, Sian Caesar, Katherine Gordon-Smith, Christine Fraser, Ellie Russell, David St Clair, Allan H. Young, Nicol Ferrier, Anne Farmer, Peter McGuffin, Peter A. Holmans, Michael J. Owen, Michael C. O'Donovan, Nick Craddock

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Original languageEnglish
Pages (from-to)1347-1349
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume153
Issue number7
DOIs
Publication statusPublished - 1 Oct 2010

Keywords

  • Bipolar disorder
  • GABA receptor
  • Genetics
  • Schizoaffective disorder

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