Abstract
We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).
Original language | English |
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Pages (from-to) | 1347-1349 |
Number of pages | 3 |
Journal | American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics |
Volume | 153 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Oct 2010 |
Bibliographical note
We are indebted to all individuals who have participated in our research. Funding for recruitment and phenotype assessment has been provided by the Wellcome Trust and the Medical Research Council. The GWAS genotype analyses were funded by the Wellcome Trust and undertaken within the context of the Wellcome Trust Case Control Consortium (WTCCC). The members of the WTCCC are listed below. Follow up genotyping was funded by the Wellcome Trust.Keywords
- Bipolar disorder
- GABA receptor
- Genetics
- Schizoaffective disorder