Variation at the GABAA receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K. Green, Detelina Grozeva, Valentina Moskvina, Marian L. Hamshere, Ian R. Jones, Lisa Jones, Liz Forty, Sian Caesar, Katherine Gordon-Smith, Christine Fraser, Ellie Russell, David St Clair, Allan H. Young, Nicol Ferrier, Anne Farmer, Peter McGuffin, Peter A. Holmans, Michael J. Owen, Michael C. O'Donovan, Nick Craddock

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Original languageEnglish
Pages (from-to)1347-1349
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume153
Issue number7
DOIs
Publication statusPublished - 1 Oct 2010

Keywords

  • Bipolar disorder
  • GABA receptor
  • Genetics
  • Schizoaffective disorder

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Green, E. K., Grozeva, D., Moskvina, V., Hamshere, M. L., Jones, I. R., Jones, L., Forty, L., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., St Clair, D., Young, A. H., Ferrier, N., Farmer, A., McGuffin, P., Holmans, P. A., Owen, M. J., O'Donovan, M. C., & Craddock, N. (2010). Variation at the GABAA receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153(7), 1347-1349. https://doi.org/10.1002/ajmg.b.31108