Variation at the GABAA receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K. Green; Detelina Grozeva; Valentina Moskvina; Marian L. Hamshere; Ian R. Jones; Lisa Jones; Liz Forty; Sian Caesar; Katherine Gordon-Smith; Christine Fraser; Ellie Russell; David St Clair; Allan H. Young; Nicol Ferrier; Anne Farmer; Peter McGuffin; Peter A. Holmans; Michael J. Owen; Michael C. O'Donovan; Nick Craddock

doi:10.1002/ajmg.b.31108

Variation at the GABA_A receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K. Green, Detelina Grozeva, Valentina Moskvina, Marian L. Hamshere, Ian R. Jones, Lisa Jones, Liz Forty, Sian Caesar, Katherine Gordon-Smith, Christine Fraser, Ellie Russell, David St Clair, Allan H. Young, Nicol Ferrier, Anne Farmer, Peter McGuffin, Peter A. Holmans, Michael J. Owen, Michael C. O'Donovan, Nick Craddock

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We have previously reported evidence that variation at GABA_A receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Original language	English
Pages (from-to)	1347-1349
Number of pages	3
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	153
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.31108
Publication status	Published - 1 Oct 2010

Keywords

Bipolar disorder
GABA receptor
Genetics
Schizoaffective disorder

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10.1002/ajmg.b.31108

Cite this

Green, E. K., Grozeva, D., Moskvina, V., Hamshere, M. L., Jones, I. R., Jones, L., Forty, L., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., St Clair, D., Young, A. H., Ferrier, N., Farmer, A., McGuffin, P., Holmans, P. A., Owen, M. J., O'Donovan, M. C., & Craddock, N. (2010). Variation at the GABA_A receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153(7), 1347-1349. https://doi.org/10.1002/ajmg.b.31108

Variation at the GABA_A receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. / Green, Elaine K.; Grozeva, Detelina; Moskvina, Valentina et al.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 153, No. 7, 01.10.2010, p. 1347-1349.

Research output: Contribution to journal › Article › peer-review

Green, EK, Grozeva, D, Moskvina, V, Hamshere, ML, Jones, IR, Jones, L, Forty, L, Caesar, S, Gordon-Smith, K, Fraser, C, Russell, E, St Clair, D, Young, AH, Ferrier, N, Farmer, A, McGuffin, P, Holmans, PA, Owen, MJ, O'Donovan, MC & Craddock, N 2010, 'Variation at the GABA_A receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 153, no. 7, pp. 1347-1349. https://doi.org/10.1002/ajmg.b.31108

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abstract = "We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).",

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