We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).
|Number of pages||3|
|Journal||American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics|
|Publication status||Published - 1 Oct 2010|
- Bipolar disorder
- GABA receptor
- Schizoaffective disorder