Variation in human water turnover associated with environmental and lifestyle factors

Yosuke Yamada; Xueying Zhang; Mary E T Henderson; Hiroyuki Sagayama; Herman Pontzer; Daiki Watanabe; Tsukasa Yoshida; Misaka Kimura; Philip N Ainslie; Lene F Andersen; Liam J Anderson; Lenore Arab; Issad Baddou; Kweku Bedu-Addo; Ellen E Blaak; Stephane Blanc; Alberto G Bonomi; Carlijn V C Bouten; Pascal Bovet; Maciej S Buchowski; Nancy F Butte; Stefan G Camps; Graeme L Close; Jamie A Cooper; Richard Cooper; Sai Krupa Das; Lara R Dugas; Simon Eaton; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W Fudge; Annelies H Goris; Michael Gurven; Lewis G Halsey; Catherine Hambly; Asmaa El Hamdouchi; Marije B Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M Joosen; Peter Katzmarzyk; Kitty P Kempen; William E Kraus; Wantanee Kriengsinyos; Robert F Kushner; Estelle V Lambert; William R Leonard; Nader Lessan; John R Speakman; International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

doi:10.1126/science.abm8668

Variation in human water turnover associated with environmental and lifestyle factors

Yosuke Yamada^* (Corresponding Author), Xueying Zhang, Mary E T Henderson, Hiroyuki Sagayama^* (Corresponding Author), Herman Pontzer^* (Corresponding Author), Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S BuchowskiNancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Lewis G Halsey, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, William E Kraus, Wantanee Kriengsinyos, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, John R Speakman^* (Corresponding Author), International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking ( 2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

Original language	English
Pages (from-to)	909-915
Number of pages	7
Journal	Science
Volume	378
Issue number	6622
Early online date	24 Nov 2022
DOIs	https://doi.org/10.1126/science.abm8668
Publication status	Published - 25 Nov 2022

Bibliographical note

Acknowledgments: We thank the International Atomic Energy Agency (IAEA), Taiyo Nippon Sanso, and SERCON for their support and T. Oono for his tremendous efforts at fundraising on our behalf. Y.Y., T.Y., and M.M. thank K. Abe for his support. Y.Y. and M.K. would like to pay gratitude and respect to their mentor, T. Morimoto, an emeritus professor of the Department of Physiology, Kyoto Prefectural University of Medicine, who passed away in July 2019.

Funding: The IAEA DLW Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding support for the database from the US National Science Foundation (grant BCS-1824466 to H.P.) and the Chinese Academy of Sciences (CAS grant 153E11KYSB20190045 to J.R.S.). The funders played no role in the content of this manuscript.

Data Availability Statement

All data used in these analyses are freely available on the IAEA DLW Database, which can be found at https://doubly-labelled-water-database.iaea.org/home or www.dlwdatabase.org.

Keywords

Female
Pregnancy
Humans
Water
Life Style
Humidity
Exercise
Social Class
ADULTS
CLIMATE-CHANGE
HYDRATION
STRATEGIES
DENSITY
ENERGY-EXPENDITURE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Yamada, Y., Zhang, X., Henderson, M. E. T., Sagayama, H., Pontzer, H., Watanabe, D., Yoshida, T., Kimura, M., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., ... International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium (2022). Variation in human water turnover associated with environmental and lifestyle factors. Science, 378(6622), 909-915. https://doi.org/10.1126/science.abm8668

Yamada, Y, Zhang, X, Henderson, MET, Sagayama, H, Pontzer, H, Watanabe, D, Yoshida, T, Kimura, M, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SG, Close, GL, Cooper, JA, Cooper, R, Das, SK, Dugas, LR, Eaton, S, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Halsey, LG, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kraus, WE, Kriengsinyos, W, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Speakman, JR & International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium 2022, 'Variation in human water turnover associated with environmental and lifestyle factors', Science, vol. 378, no. 6622, pp. 909-915. https://doi.org/10.1126/science.abm8668

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abstract = "Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking ( 2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors. ",

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AU - Yamada, Yosuke

AU - Zhang, Xueying

AU - Henderson, Mary E T

AU - Sagayama, Hiroyuki

AU - Pontzer, Herman

AU - Watanabe, Daiki

AU - Yoshida, Tsukasa

AU - Kimura, Misaka

AU - Ainslie, Philip N

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AU - Anderson, Liam J

AU - Arab, Lenore

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AU - Blanc, Stephane

AU - Bonomi, Alberto G

AU - Bouten, Carlijn V C

AU - Bovet, Pascal

AU - Buchowski, Maciej S

AU - Butte, Nancy F

AU - Camps, Stefan G

AU - Close, Graeme L

AU - Cooper, Jamie A

AU - Cooper, Richard

AU - Das, Sai Krupa

AU - Dugas, Lara R

AU - Eaton, Simon

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W

AU - Goris, Annelies H

AU - Gurven, Michael

AU - Halsey, Lewis G

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marije B

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P

AU - Kraus, William E

AU - Kriengsinyos, Wantanee

AU - Kushner, Robert F

AU - Lambert, Estelle V

AU - Leonard, William R

AU - Lessan, Nader

AU - Speakman, John R

AU - International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

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PY - 2022/11/25

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N2 - Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking ( 2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

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KW - Pregnancy

KW - Humans

KW - Water

KW - Life Style

KW - Humidity

KW - Exercise

KW - Social Class

KW - ADULTS

KW - CLIMATE-CHANGE

KW - HYDRATION

KW - STRATEGIES

KW - DENSITY

KW - ENERGY-EXPENDITURE

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ER -

Variation in human water turnover associated with environmental and lifestyle factors

Abstract

Bibliographical note

Data Availability Statement

Keywords

UN SDGs

Access to Document

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