Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna Beedie; Alexandra J. Diamond; Lucas Rosa Fraga; William D. Figg; Neil Vargesson

doi:10.1016/j.reprotox.2016.11.013

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna Beedie, Alexandra J. Diamond, Lucas Rosa Fraga, William D. Figg, Neil Vargesson

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

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Abstract

The development of new angiogenic inhibitors highlights a need for robust
screening assays that adequately capture the complexity of vessel formation,
and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic
agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

Original language	English
Pages (from-to)	49-59
Number of pages	10
Journal	Reproductive Toxicology
Volume	70
Early online date	22 Nov 2016
DOIs	https://doi.org/10.1016/j.reprotox.2016.11.013
Publication status	Published - 1 Jun 2017

Keywords

angiogenesis
chicken
zebrafish
mouse
rat
rabbit
non-human primates
thalidomide

Access to Document

10.1016/j.reprotox.2016.11.013Licence: Unspecified

Accepted Manuscript
©2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 232 KBLicence: CC BY-NC-ND

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title = "Vertebrate embryos as tools for anti-angiogenic drug screening and function",

abstract = "The development of new angiogenic inhibitors highlights a need for robustscreening assays that adequately capture the complexity of vessel formation,and allow for the quantitative evaluation of the teratogenicity of new antiangiogenicagents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.",

keywords = "angiogenesis, chicken, zebrafish, mouse, rat, rabbit, non-human primates, thalidomide",

author = "Shaunna Beedie and Diamond, {Alexandra J.} and {Rosa Fraga}, Lucas and Figg, {William D.} and Neil Vargesson",

note = "Shaunna Beedie is a recipient of a Wellcome Trust-NIH PhD Studentship (Grant number 098252/Z/12/Z). Alexandra J. Diamond is a recipient of a BBSRC EastBIO DTP PhD Scholarship. Lucas Rosa Fraga is a recepient of a PhD scholarship from the Science Without Borders program – CNPq Brazil – INAGEMP/ Grant CNPq 573993/2008-4 Shaunna Beedie and William D. Figg are supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organization imply endorsement by the U.S. Government.",

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AU - Diamond, Alexandra J.

AU - Rosa Fraga, Lucas

AU - Figg, William D.

AU - Vargesson, Neil

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N2 - The development of new angiogenic inhibitors highlights a need for robustscreening assays that adequately capture the complexity of vessel formation,and allow for the quantitative evaluation of the teratogenicity of new antiangiogenicagents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

AB - The development of new angiogenic inhibitors highlights a need for robustscreening assays that adequately capture the complexity of vessel formation,and allow for the quantitative evaluation of the teratogenicity of new antiangiogenicagents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

KW - angiogenesis

KW - chicken

KW - zebrafish

KW - mouse

KW - rat

KW - rabbit

KW - non-human primates

KW - thalidomide

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DO - 10.1016/j.reprotox.2016.11.013

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