Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna Beedie, Alexandra J. Diamond, Lucas Rosa Fraga, William D. Figg, Neil Vargesson

Research output: Contribution to journalArticle

5 Citations (Scopus)
16 Downloads (Pure)

Abstract

The development of new angiogenic inhibitors highlights a need for robust
screening assays that adequately capture the complexity of vessel formation,
and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic
agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
Original languageEnglish
Pages (from-to)49-59
Number of pages10
JournalReproductive Toxicology
Volume70
Early online date22 Nov 2016
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • angiogenesis
  • chicken
  • zebrafish
  • mouse
  • rat
  • rabbit
  • non-human primates
  • thalidomide

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