Abstract
The development of new angiogenic inhibitors highlights a need for robust
screening assays that adequately capture the complexity of vessel formation,
and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic
agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
screening assays that adequately capture the complexity of vessel formation,
and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic
agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
Original language | English |
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Pages (from-to) | 49-59 |
Number of pages | 10 |
Journal | Reproductive Toxicology |
Volume | 70 |
Early online date | 22 Nov 2016 |
DOIs | |
Publication status | Published - 1 Jun 2017 |
Keywords
- angiogenesis
- chicken
- zebrafish
- mouse
- rat
- rabbit
- non-human primates
- thalidomide