Vesicular trafficking in osteoclasts

Fraser Coxon, Adam Taylor

Research output: Contribution to journalLiterature reviewpeer-review

87 Citations (Scopus)


Bone-resorbing osteoclasts are highly dependent on vesicular trafficking pathways that are regulated by Rab GTPases. In particular, polarised transport of acidic vesicles of the endocytic/lysosomal pathway is required for formation of the ruffled border, the resorptive organelle of the osteoclast. The breakdown products of resorption are then transported through the osteoclast by transcytosis, enabling their excretion. In this review, we summarise these trafficking routes, highlight the emerging evidence that the bone disease osteopetrosis results from defects in vesicular trafficking in osteoclasts, and outline the similarities between the endocytic/lysosomal compartment in osteoclasts and secretory lysosomes in other cell types.
Original languageEnglish
Pages (from-to)424-433
Number of pages10
JournalSeminars in Cell & Developmental Biology
Issue number5
Early online date14 Aug 2008
Publication statusPublished - Oct 2008


  • Animals
  • Bone Resorption
  • Cell Compartmentation
  • Cell Polarity
  • Endocytosis
  • Endosomes
  • Humans
  • Lysosomes
  • Models, Biological
  • Osteoclasts
  • Prenylation
  • Protein Transport
  • rab GTP-Binding Proteins
  • vesicular trafficking
  • Rab
  • Osteoperosis
  • Lysosome


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