Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D

Helen M. MacDonald, Alexandra Mavroeidi, Rebecca J. Barr, Alison J. Black, William D. Fraser, David M. Reid

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

For 5 months a year the UK has insufficient sunlight for cutaneous synthesis of vitamin D and winter requirements are met from stores made the previous summer. Although there are few natural dietary sources, dietary intake may help maintain vitamin D status.

We investigated the relationship between 25-hydroxyvitamin D (25(OH)D), bone health, overweight, sunlight exposure and dietary vitamin D in 3113 women (age 54.8 [SD 2.3] years) living at latitude 57°N between 1998–2000. Serum 25(OH)D was measured by high performance liquid chromatography (HPLC), dietary intakes (food frequency questionnaire, n = 2598), sunlight exposure (questionnaire, n = 2402) and bone markers were assessed. Bone mineral density (BMD) was measured by dual x-ray absorptiometry in all women at the sampling visit and 6 years before. Seasonal variation in 25(OH)D was not substantial with a peak in the autumn (23.7 [9.9] ng/ml) and a nadir in spring (19.7 [7.6] ng/ml). Daily intake of vitamin D was 4.2 [2.5] μg from food only and 5.8 [4.0] μg including vitamin D from cod liver oil and multivitamins. The latter was associated with 25(OH)D at each season whereas vitamin D simply from food was associated with 25(OH)D in winter and spring only. Sunlight exposure was associated with 25(OH)D in summer and autumn. 25(OH)D was negatively associated with increased bone resorption and bone loss (P < 0.05) remaining significant after adjustment for confounders (age, weight, height, menopausal status/HRT use, physical activity and socio-economic status). Using an insufficiency cut-off of < 28 ng/ml 25(OH)D, showed lower concentrations of bone resorption markers in the upper category (fDPD/Cr 5.1 [1.7] nmol/mmol compared to 5.3 [2.1] nmol/mmol, P = 0.03) and no difference in BMD or bone loss. 25(OH)D was lower (P < 0.01) and parathyroid hormone higher (P < 0.01) in the top quintile of body mass index. In conclusion, low vitamin D status is associated with greater bone turnover, bone loss and obesity. Diet appears to attenuate the seasonal variation of vitamin D status in early postmenopausal women at northerly latitude where quality of sunlight for production of vitamin D is diminished.
Original languageEnglish
Pages (from-to)996-1003
Number of pages8
JournalBone
Volume42
Issue number5
Early online date9 Feb 2008
DOIs
Publication statusPublished - May 2008

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Sunlight
Vitamin D
Bone and Bones
Health
Bone Resorption
Bone Density
Cod Liver Oil
Food
Bone Remodeling
Parathyroid Hormone
Body Mass Index
Obesity
Eating
High Pressure Liquid Chromatography
Economics
X-Rays
Exercise
Diet
Weights and Measures
Skin

Keywords

  • analysis of variance
  • bone density
  • bone and bones
  • cohort studies
  • collagen type I
  • diet
  • dietary supplements
  • female
  • food analysis
  • Great Britain
  • holidays
  • humans
  • middle aged
  • overweight
  • parathyroid hormone
  • peptides
  • phosphopeptides
  • postmenopause
  • procollagen
  • seasons
  • social class
  • sunlight
  • vitamin A
  • vitamin D
  • 25-hydroxy vitamin D
  • postmenopausal women
  • bone loss
  • dietary vitamin D
  • sunlight exposure

Cite this

Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D. / MacDonald, Helen M.; Mavroeidi, Alexandra; Barr, Rebecca J.; Black, Alison J.; Fraser, William D.; Reid, David M.

In: Bone, Vol. 42, No. 5, 05.2008, p. 996-1003.

Research output: Contribution to journalArticle

MacDonald, Helen M. ; Mavroeidi, Alexandra ; Barr, Rebecca J. ; Black, Alison J. ; Fraser, William D. ; Reid, David M. / Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D. In: Bone. 2008 ; Vol. 42, No. 5. pp. 996-1003.
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abstract = "For 5 months a year the UK has insufficient sunlight for cutaneous synthesis of vitamin D and winter requirements are met from stores made the previous summer. Although there are few natural dietary sources, dietary intake may help maintain vitamin D status.We investigated the relationship between 25-hydroxyvitamin D (25(OH)D), bone health, overweight, sunlight exposure and dietary vitamin D in 3113 women (age 54.8 [SD 2.3] years) living at latitude 57°N between 1998–2000. Serum 25(OH)D was measured by high performance liquid chromatography (HPLC), dietary intakes (food frequency questionnaire, n = 2598), sunlight exposure (questionnaire, n = 2402) and bone markers were assessed. Bone mineral density (BMD) was measured by dual x-ray absorptiometry in all women at the sampling visit and 6 years before. Seasonal variation in 25(OH)D was not substantial with a peak in the autumn (23.7 [9.9] ng/ml) and a nadir in spring (19.7 [7.6] ng/ml). Daily intake of vitamin D was 4.2 [2.5] μg from food only and 5.8 [4.0] μg including vitamin D from cod liver oil and multivitamins. The latter was associated with 25(OH)D at each season whereas vitamin D simply from food was associated with 25(OH)D in winter and spring only. Sunlight exposure was associated with 25(OH)D in summer and autumn. 25(OH)D was negatively associated with increased bone resorption and bone loss (P < 0.05) remaining significant after adjustment for confounders (age, weight, height, menopausal status/HRT use, physical activity and socio-economic status). Using an insufficiency cut-off of < 28 ng/ml 25(OH)D, showed lower concentrations of bone resorption markers in the upper category (fDPD/Cr 5.1 [1.7] nmol/mmol compared to 5.3 [2.1] nmol/mmol, P = 0.03) and no difference in BMD or bone loss. 25(OH)D was lower (P < 0.01) and parathyroid hormone higher (P < 0.01) in the top quintile of body mass index. In conclusion, low vitamin D status is associated with greater bone turnover, bone loss and obesity. Diet appears to attenuate the seasonal variation of vitamin D status in early postmenopausal women at northerly latitude where quality of sunlight for production of vitamin D is diminished.",
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T1 - Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D

AU - MacDonald, Helen M.

AU - Mavroeidi, Alexandra

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AU - Fraser, William D.

AU - Reid, David M.

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N2 - For 5 months a year the UK has insufficient sunlight for cutaneous synthesis of vitamin D and winter requirements are met from stores made the previous summer. Although there are few natural dietary sources, dietary intake may help maintain vitamin D status.We investigated the relationship between 25-hydroxyvitamin D (25(OH)D), bone health, overweight, sunlight exposure and dietary vitamin D in 3113 women (age 54.8 [SD 2.3] years) living at latitude 57°N between 1998–2000. Serum 25(OH)D was measured by high performance liquid chromatography (HPLC), dietary intakes (food frequency questionnaire, n = 2598), sunlight exposure (questionnaire, n = 2402) and bone markers were assessed. Bone mineral density (BMD) was measured by dual x-ray absorptiometry in all women at the sampling visit and 6 years before. Seasonal variation in 25(OH)D was not substantial with a peak in the autumn (23.7 [9.9] ng/ml) and a nadir in spring (19.7 [7.6] ng/ml). Daily intake of vitamin D was 4.2 [2.5] μg from food only and 5.8 [4.0] μg including vitamin D from cod liver oil and multivitamins. The latter was associated with 25(OH)D at each season whereas vitamin D simply from food was associated with 25(OH)D in winter and spring only. Sunlight exposure was associated with 25(OH)D in summer and autumn. 25(OH)D was negatively associated with increased bone resorption and bone loss (P < 0.05) remaining significant after adjustment for confounders (age, weight, height, menopausal status/HRT use, physical activity and socio-economic status). Using an insufficiency cut-off of < 28 ng/ml 25(OH)D, showed lower concentrations of bone resorption markers in the upper category (fDPD/Cr 5.1 [1.7] nmol/mmol compared to 5.3 [2.1] nmol/mmol, P = 0.03) and no difference in BMD or bone loss. 25(OH)D was lower (P < 0.01) and parathyroid hormone higher (P < 0.01) in the top quintile of body mass index. In conclusion, low vitamin D status is associated with greater bone turnover, bone loss and obesity. Diet appears to attenuate the seasonal variation of vitamin D status in early postmenopausal women at northerly latitude where quality of sunlight for production of vitamin D is diminished.

AB - For 5 months a year the UK has insufficient sunlight for cutaneous synthesis of vitamin D and winter requirements are met from stores made the previous summer. Although there are few natural dietary sources, dietary intake may help maintain vitamin D status.We investigated the relationship between 25-hydroxyvitamin D (25(OH)D), bone health, overweight, sunlight exposure and dietary vitamin D in 3113 women (age 54.8 [SD 2.3] years) living at latitude 57°N between 1998–2000. Serum 25(OH)D was measured by high performance liquid chromatography (HPLC), dietary intakes (food frequency questionnaire, n = 2598), sunlight exposure (questionnaire, n = 2402) and bone markers were assessed. Bone mineral density (BMD) was measured by dual x-ray absorptiometry in all women at the sampling visit and 6 years before. Seasonal variation in 25(OH)D was not substantial with a peak in the autumn (23.7 [9.9] ng/ml) and a nadir in spring (19.7 [7.6] ng/ml). Daily intake of vitamin D was 4.2 [2.5] μg from food only and 5.8 [4.0] μg including vitamin D from cod liver oil and multivitamins. The latter was associated with 25(OH)D at each season whereas vitamin D simply from food was associated with 25(OH)D in winter and spring only. Sunlight exposure was associated with 25(OH)D in summer and autumn. 25(OH)D was negatively associated with increased bone resorption and bone loss (P < 0.05) remaining significant after adjustment for confounders (age, weight, height, menopausal status/HRT use, physical activity and socio-economic status). Using an insufficiency cut-off of < 28 ng/ml 25(OH)D, showed lower concentrations of bone resorption markers in the upper category (fDPD/Cr 5.1 [1.7] nmol/mmol compared to 5.3 [2.1] nmol/mmol, P = 0.03) and no difference in BMD or bone loss. 25(OH)D was lower (P < 0.01) and parathyroid hormone higher (P < 0.01) in the top quintile of body mass index. In conclusion, low vitamin D status is associated with greater bone turnover, bone loss and obesity. Diet appears to attenuate the seasonal variation of vitamin D status in early postmenopausal women at northerly latitude where quality of sunlight for production of vitamin D is diminished.

KW - analysis of variance

KW - bone density

KW - bone and bones

KW - cohort studies

KW - collagen type I

KW - diet

KW - dietary supplements

KW - female

KW - food analysis

KW - Great Britain

KW - holidays

KW - humans

KW - middle aged

KW - overweight

KW - parathyroid hormone

KW - peptides

KW - phosphopeptides

KW - postmenopause

KW - procollagen

KW - seasons

KW - social class

KW - sunlight

KW - vitamin A

KW - vitamin D

KW - 25-hydroxy vitamin D

KW - postmenopausal women

KW - bone loss

KW - dietary vitamin D

KW - sunlight exposure

U2 - 10.1016/j.bone.2008.01.011

DO - 10.1016/j.bone.2008.01.011

M3 - Article

C2 - 18329355

VL - 42

SP - 996

EP - 1003

JO - Bone

JF - Bone

SN - 8756-3282

IS - 5

ER -