Vitamin E homologues α - and γ-tocopherol are not associated with bone turnover markers or bone mineral density in perimenopausal and postmenopausal women

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Abstract

IntroductionVitamin E has anti-oxidant and -inflammatory properties hypothesized to benefit bone, but limited studies exist regarding its homologues. We examined circulating and dietary α- and γ-tocopherols with bone turnover markers (BTMs) and bone mineral density (BMD), and the role of inflammation in this relationship. MethodsWe performed two cross-sectional analyses from two visits (V2: 1997-1999 n=3883; V3: 2007-2011 n=2130) of the Aberdeen Prospective Osteoporosis Screening Study. Dietary and supplement intake by food frequency questionnaire were assessed at both visits. V2 BTMs (urinary free pyridinoline and deoxypyridinoline, serum N-terminal propeptide of type 1 collagen) and V3 serum α- and γ-tocopherols, inflammatory markers (interleukin-6 [IL-6], serum amyloid A [SAA], high-sensitivity C-reactive protein [hs-CRP], E-selectin), and dual x-ray absorptiometry BMD at the femoral neck and lumbar spine were collected. Food sources of tocopherol homologues and diet-serum correlations were determined. The relationships between dietary tocopherols and BTMs (V2), and dietary and serum tocopherols with BMD (V3) were examined by multivariable regression (adjusting for age, cholesterol, inflammatory markers, carotenoids, body mass index, height, physical activity level, alcohol intake, smoking status, and national deprivation category).ResultsSerum γ-tocopherol was associated with increasing concentrations of hs-CRP, SAA, and E-selectin (P-trend all <0.0001), while α-tocopherol was associated with decreasing concentrations of IL-6 and hs-CRP (P-trend all <0.001). Controlling for covariates, serum α-tocopherol was positively associated with BMD at the femoral neck (β=0.002, P=0.04) among those not reporting vitamin E supplementation. ConclusionWe did not find biologically meaningful results between dietary and tocopherol homologues with BTMs or BMD.
Original languageEnglish
Pages (from-to)2281-2290
Number of pages10
JournalOsteoporosis International
Volume27
Issue number7
Early online date2 May 2016
DOIs
Publication statusPublished - Jul 2016

Fingerprint

Tocopherols
Bone Remodeling
Vitamin E
Bone Density
Bone and Bones
C-Reactive Protein
Serum Amyloid A Protein
Serum
E-Selectin
Femur Neck
Interleukin-6
Carotenoids
Dietary Supplements
Collagen Type I
Oxidants
Osteoporosis
Spine
Body Mass Index
Anti-Inflammatory Agents
Cross-Sectional Studies

Keywords

  • bone mineral density
  • bone markers
  • vitamin E
  • alpha-tocopherol
  • gamma-tocopherol
  • inflammation
  • postmenopausal women

Cite this

@article{6bda1c2ef5ca48278237015c005c69aa,
title = "Vitamin E homologues α - and γ-tocopherol are not associated with bone turnover markers or bone mineral density in perimenopausal and postmenopausal women",
abstract = "IntroductionVitamin E has anti-oxidant and -inflammatory properties hypothesized to benefit bone, but limited studies exist regarding its homologues. We examined circulating and dietary α- and γ-tocopherols with bone turnover markers (BTMs) and bone mineral density (BMD), and the role of inflammation in this relationship. MethodsWe performed two cross-sectional analyses from two visits (V2: 1997-1999 n=3883; V3: 2007-2011 n=2130) of the Aberdeen Prospective Osteoporosis Screening Study. Dietary and supplement intake by food frequency questionnaire were assessed at both visits. V2 BTMs (urinary free pyridinoline and deoxypyridinoline, serum N-terminal propeptide of type 1 collagen) and V3 serum α- and γ-tocopherols, inflammatory markers (interleukin-6 [IL-6], serum amyloid A [SAA], high-sensitivity C-reactive protein [hs-CRP], E-selectin), and dual x-ray absorptiometry BMD at the femoral neck and lumbar spine were collected. Food sources of tocopherol homologues and diet-serum correlations were determined. The relationships between dietary tocopherols and BTMs (V2), and dietary and serum tocopherols with BMD (V3) were examined by multivariable regression (adjusting for age, cholesterol, inflammatory markers, carotenoids, body mass index, height, physical activity level, alcohol intake, smoking status, and national deprivation category).ResultsSerum γ-tocopherol was associated with increasing concentrations of hs-CRP, SAA, and E-selectin (P-trend all <0.0001), while α-tocopherol was associated with decreasing concentrations of IL-6 and hs-CRP (P-trend all <0.001). Controlling for covariates, serum α-tocopherol was positively associated with BMD at the femoral neck (β=0.002, P=0.04) among those not reporting vitamin E supplementation. ConclusionWe did not find biologically meaningful results between dietary and tocopherol homologues with BTMs or BMD.",
keywords = "bone mineral density, bone markers, vitamin E, alpha-tocopherol, gamma-tocopherol, inflammation, postmenopausal women",
author = "Yang, {T C} and Duthie, {G G} and Aucott, {L S} and MacDonald, {H M}",
note = "This study was supported by the Foods Standards Agency and the UK Department of Health (grant number N05086) and the Scottish Funding Council. We are grateful for funding from the Scottish Government's Rural and Environmental Science and Analytical Services (RESAS) Food, Land and People Programme. Any views expressed are the authors’ own; none of the funders had a role in design, analysis, or writing of the present study.",
year = "2016",
month = "7",
doi = "10.1007/s00198-015-3470-x",
language = "English",
volume = "27",
pages = "2281--2290",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "SPRINGER-VERLAG LONDON LTD",
number = "7",

}

TY - JOUR

T1 - Vitamin E homologues α - and γ-tocopherol are not associated with bone turnover markers or bone mineral density in perimenopausal and postmenopausal women

AU - Yang, T C

AU - Duthie, G G

AU - Aucott, L S

AU - MacDonald, H M

N1 - This study was supported by the Foods Standards Agency and the UK Department of Health (grant number N05086) and the Scottish Funding Council. We are grateful for funding from the Scottish Government's Rural and Environmental Science and Analytical Services (RESAS) Food, Land and People Programme. Any views expressed are the authors’ own; none of the funders had a role in design, analysis, or writing of the present study.

PY - 2016/7

Y1 - 2016/7

N2 - IntroductionVitamin E has anti-oxidant and -inflammatory properties hypothesized to benefit bone, but limited studies exist regarding its homologues. We examined circulating and dietary α- and γ-tocopherols with bone turnover markers (BTMs) and bone mineral density (BMD), and the role of inflammation in this relationship. MethodsWe performed two cross-sectional analyses from two visits (V2: 1997-1999 n=3883; V3: 2007-2011 n=2130) of the Aberdeen Prospective Osteoporosis Screening Study. Dietary and supplement intake by food frequency questionnaire were assessed at both visits. V2 BTMs (urinary free pyridinoline and deoxypyridinoline, serum N-terminal propeptide of type 1 collagen) and V3 serum α- and γ-tocopherols, inflammatory markers (interleukin-6 [IL-6], serum amyloid A [SAA], high-sensitivity C-reactive protein [hs-CRP], E-selectin), and dual x-ray absorptiometry BMD at the femoral neck and lumbar spine were collected. Food sources of tocopherol homologues and diet-serum correlations were determined. The relationships between dietary tocopherols and BTMs (V2), and dietary and serum tocopherols with BMD (V3) were examined by multivariable regression (adjusting for age, cholesterol, inflammatory markers, carotenoids, body mass index, height, physical activity level, alcohol intake, smoking status, and national deprivation category).ResultsSerum γ-tocopherol was associated with increasing concentrations of hs-CRP, SAA, and E-selectin (P-trend all <0.0001), while α-tocopherol was associated with decreasing concentrations of IL-6 and hs-CRP (P-trend all <0.001). Controlling for covariates, serum α-tocopherol was positively associated with BMD at the femoral neck (β=0.002, P=0.04) among those not reporting vitamin E supplementation. ConclusionWe did not find biologically meaningful results between dietary and tocopherol homologues with BTMs or BMD.

AB - IntroductionVitamin E has anti-oxidant and -inflammatory properties hypothesized to benefit bone, but limited studies exist regarding its homologues. We examined circulating and dietary α- and γ-tocopherols with bone turnover markers (BTMs) and bone mineral density (BMD), and the role of inflammation in this relationship. MethodsWe performed two cross-sectional analyses from two visits (V2: 1997-1999 n=3883; V3: 2007-2011 n=2130) of the Aberdeen Prospective Osteoporosis Screening Study. Dietary and supplement intake by food frequency questionnaire were assessed at both visits. V2 BTMs (urinary free pyridinoline and deoxypyridinoline, serum N-terminal propeptide of type 1 collagen) and V3 serum α- and γ-tocopherols, inflammatory markers (interleukin-6 [IL-6], serum amyloid A [SAA], high-sensitivity C-reactive protein [hs-CRP], E-selectin), and dual x-ray absorptiometry BMD at the femoral neck and lumbar spine were collected. Food sources of tocopherol homologues and diet-serum correlations were determined. The relationships between dietary tocopherols and BTMs (V2), and dietary and serum tocopherols with BMD (V3) were examined by multivariable regression (adjusting for age, cholesterol, inflammatory markers, carotenoids, body mass index, height, physical activity level, alcohol intake, smoking status, and national deprivation category).ResultsSerum γ-tocopherol was associated with increasing concentrations of hs-CRP, SAA, and E-selectin (P-trend all <0.0001), while α-tocopherol was associated with decreasing concentrations of IL-6 and hs-CRP (P-trend all <0.001). Controlling for covariates, serum α-tocopherol was positively associated with BMD at the femoral neck (β=0.002, P=0.04) among those not reporting vitamin E supplementation. ConclusionWe did not find biologically meaningful results between dietary and tocopherol homologues with BTMs or BMD.

KW - bone mineral density

KW - bone markers

KW - vitamin E

KW - alpha-tocopherol

KW - gamma-tocopherol

KW - inflammation

KW - postmenopausal women

U2 - 10.1007/s00198-015-3470-x

DO - 10.1007/s00198-015-3470-x

M3 - Article

VL - 27

SP - 2281

EP - 2290

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 7

ER -