Abstract
Smokers incur a sustained free radical load that may increase their vitamin E requirement. Erythrocytes of male smokers from a Scottish population with a habitually low vitamin E intake were more susceptible to hydrogen peroxide-stimulated peroxidation than were those from nonsmokers (P < 0.001). Plasma concentrations of lipid peroxides, thiobarbituric acid reactive substances, and conjugated dienes were also elevated in smokers compared with nonsmokers (P < 0.05). These indexes of oxidative stress were markedly decreased (P < 0.001) in the smokers and nonsmokers after consumption of 280 mg dl-alpha tocopherol acetate/d for 10 wk. Platelet numbers in serum of both smokers and nonsmokers were also decreased by vitamin E supplementation (P < 0.02). Although the clinical significance of the results is unclear, elevated indexes of lipid peroxidation are associated with the pathogenesis of atherosclerosis, and platelets are involved with fibrinolysis. Therefore, both smokers and nonsmokers may benefit from increased vitamin E intakes.
| Original language | English |
|---|---|
| Pages (from-to) | 383-387 |
| Number of pages | 5 |
| Journal | The American Journal of Clinical Nutrition |
| Volume | 60 |
| Issue number | 3 |
| Publication status | Published - Sep 1994 |
Keywords
- vitamin-E supplementation
- lipid peroxidation
- cardiovascular disease
- atherosclerosis
- smoking
- platelets
- low-density-lipoprotein
- coronary heart-disease
- cigarette-smoking
- antioxidants
- invitro
Cite this
Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged. / Brown, K M; Morrice, P C; Duthie, G G.
In: The American Journal of Clinical Nutrition, Vol. 60, No. 3, 09.1994, p. 383-387.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged
AU - Brown, K M
AU - Morrice, P C
AU - Duthie, G G
PY - 1994/9
Y1 - 1994/9
N2 - Smokers incur a sustained free radical load that may increase their vitamin E requirement. Erythrocytes of male smokers from a Scottish population with a habitually low vitamin E intake were more susceptible to hydrogen peroxide-stimulated peroxidation than were those from nonsmokers (P < 0.001). Plasma concentrations of lipid peroxides, thiobarbituric acid reactive substances, and conjugated dienes were also elevated in smokers compared with nonsmokers (P < 0.05). These indexes of oxidative stress were markedly decreased (P < 0.001) in the smokers and nonsmokers after consumption of 280 mg dl-alpha tocopherol acetate/d for 10 wk. Platelet numbers in serum of both smokers and nonsmokers were also decreased by vitamin E supplementation (P < 0.02). Although the clinical significance of the results is unclear, elevated indexes of lipid peroxidation are associated with the pathogenesis of atherosclerosis, and platelets are involved with fibrinolysis. Therefore, both smokers and nonsmokers may benefit from increased vitamin E intakes.
AB - Smokers incur a sustained free radical load that may increase their vitamin E requirement. Erythrocytes of male smokers from a Scottish population with a habitually low vitamin E intake were more susceptible to hydrogen peroxide-stimulated peroxidation than were those from nonsmokers (P < 0.001). Plasma concentrations of lipid peroxides, thiobarbituric acid reactive substances, and conjugated dienes were also elevated in smokers compared with nonsmokers (P < 0.05). These indexes of oxidative stress were markedly decreased (P < 0.001) in the smokers and nonsmokers after consumption of 280 mg dl-alpha tocopherol acetate/d for 10 wk. Platelet numbers in serum of both smokers and nonsmokers were also decreased by vitamin E supplementation (P < 0.02). Although the clinical significance of the results is unclear, elevated indexes of lipid peroxidation are associated with the pathogenesis of atherosclerosis, and platelets are involved with fibrinolysis. Therefore, both smokers and nonsmokers may benefit from increased vitamin E intakes.
KW - vitamin-E supplementation
KW - lipid peroxidation
KW - cardiovascular disease
KW - atherosclerosis
KW - smoking
KW - platelets
KW - low-density-lipoprotein
KW - coronary heart-disease
KW - cigarette-smoking
KW - antioxidants
KW - invitro
M3 - Article
VL - 60
SP - 383
EP - 387
JO - The American Journal of Clinical Nutrition
JF - The American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -