Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women

no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms

Helen M Macdonald, Fiona E McGuigan, Susan A Lanham-New, William D Fraser, Stuart H Ralston, David M Reid

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Abstract

Background: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.

Objective: We investigated the relation between dietary vitamin K, intake, A POE polymorphisms, and markers of bone health.

Design: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) risk and a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.

Results: Compared with quartile 3 (Q3) of energy-adjusted vitamin K, intake ((x) over bar: 116 mu g/d), women in the lowest quartile ((x) over bar: 59 mu g/d) had lower BMD (analysis of variance; FN, Q1: 0.831 +/- 0.122 g/cm(2); Q3: 0.850 +/- 0.126 g/cm(2); P < 0.001; LS, Q 1: 1.000 +/- 0.170 g/cm(2); Q3: 1.020 +/- 0.172 g/cm(2); P = 0.009), remaining significant at the FN after adjustment for age, weight, height, menopausal status or use of hormone replacement therapy, socioeconomic status, and physical activity (P = 0.04). Vitamin K, intake was associated with reduced concentrations of pyridinoline crosslinks (Q1: 5.4 +/- 2.0 nmol/mmol; Q4: 5.1 +/- 1.9 nmol/mmol; P = 0.003). Carriers of the E2 allele had greater LS BMD at visit 2 and lost less BMD than did carriers of the E4 allele (E2: -0.50 +/- 1.22%/y; E4: -0.71 +/- 1.17%/y; P = 0.05). After adjustment for confounders, the P value for BMD loss (0.03 for LS and 0.04 for FN) did not reach the level of significance required for multiple testing (P = 0.012). No interaction was observed between dietary vitamin K and APOE on BMD.

Conclusions: Vitamin K, intake was associated with markers of bone health, but no interaction was observed with APOE alleles on BMD or markers of bone turnover.

Original languageEnglish
Pages (from-to)1513-1520
Number of pages8
JournalThe American Journal of Clinical Nutrition
Volume87
Issue number5
Publication statusPublished - May 2008

Keywords

  • serum undercarboxylated osteocalcin
  • fracture risk
  • hip fracture
  • elderly-men
  • cholesterol concentrations
  • premenopausal women
  • fatty-acids
  • fruit
  • supplementation
  • osteoporosis

Cite this

Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women : no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. / Macdonald, Helen M; McGuigan, Fiona E; Lanham-New, Susan A; Fraser, William D; Ralston, Stuart H; Reid, David M.

In: The American Journal of Clinical Nutrition, Vol. 87, No. 5, 05.2008, p. 1513-1520.

Research output: Contribution to journalArticle

@article{74edea7f5b84416bb8d01e28f5f5c01d,
title = "Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms",
abstract = "Background: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.Objective: We investigated the relation between dietary vitamin K, intake, A POE polymorphisms, and markers of bone health.Design: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) risk and a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.Results: Compared with quartile 3 (Q3) of energy-adjusted vitamin K, intake ((x) over bar: 116 mu g/d), women in the lowest quartile ((x) over bar: 59 mu g/d) had lower BMD (analysis of variance; FN, Q1: 0.831 +/- 0.122 g/cm(2); Q3: 0.850 +/- 0.126 g/cm(2); P < 0.001; LS, Q 1: 1.000 +/- 0.170 g/cm(2); Q3: 1.020 +/- 0.172 g/cm(2); P = 0.009), remaining significant at the FN after adjustment for age, weight, height, menopausal status or use of hormone replacement therapy, socioeconomic status, and physical activity (P = 0.04). Vitamin K, intake was associated with reduced concentrations of pyridinoline crosslinks (Q1: 5.4 +/- 2.0 nmol/mmol; Q4: 5.1 +/- 1.9 nmol/mmol; P = 0.003). Carriers of the E2 allele had greater LS BMD at visit 2 and lost less BMD than did carriers of the E4 allele (E2: -0.50 +/- 1.22{\%}/y; E4: -0.71 +/- 1.17{\%}/y; P = 0.05). After adjustment for confounders, the P value for BMD loss (0.03 for LS and 0.04 for FN) did not reach the level of significance required for multiple testing (P = 0.012). No interaction was observed between dietary vitamin K and APOE on BMD.Conclusions: Vitamin K, intake was associated with markers of bone health, but no interaction was observed with APOE alleles on BMD or markers of bone turnover.",
keywords = "serum undercarboxylated osteocalcin, fracture risk, hip fracture, elderly-men, cholesterol concentrations, premenopausal women, fatty-acids, fruit, supplementation, osteoporosis",
author = "Macdonald, {Helen M} and McGuigan, {Fiona E} and Lanham-New, {Susan A} and Fraser, {William D} and Ralston, {Stuart H} and Reid, {David M}",
year = "2008",
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language = "English",
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pages = "1513--1520",
journal = "The American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
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TY - JOUR

T1 - Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women

T2 - no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms

AU - Macdonald, Helen M

AU - McGuigan, Fiona E

AU - Lanham-New, Susan A

AU - Fraser, William D

AU - Ralston, Stuart H

AU - Reid, David M

PY - 2008/5

Y1 - 2008/5

N2 - Background: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.Objective: We investigated the relation between dietary vitamin K, intake, A POE polymorphisms, and markers of bone health.Design: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) risk and a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.Results: Compared with quartile 3 (Q3) of energy-adjusted vitamin K, intake ((x) over bar: 116 mu g/d), women in the lowest quartile ((x) over bar: 59 mu g/d) had lower BMD (analysis of variance; FN, Q1: 0.831 +/- 0.122 g/cm(2); Q3: 0.850 +/- 0.126 g/cm(2); P < 0.001; LS, Q 1: 1.000 +/- 0.170 g/cm(2); Q3: 1.020 +/- 0.172 g/cm(2); P = 0.009), remaining significant at the FN after adjustment for age, weight, height, menopausal status or use of hormone replacement therapy, socioeconomic status, and physical activity (P = 0.04). Vitamin K, intake was associated with reduced concentrations of pyridinoline crosslinks (Q1: 5.4 +/- 2.0 nmol/mmol; Q4: 5.1 +/- 1.9 nmol/mmol; P = 0.003). Carriers of the E2 allele had greater LS BMD at visit 2 and lost less BMD than did carriers of the E4 allele (E2: -0.50 +/- 1.22%/y; E4: -0.71 +/- 1.17%/y; P = 0.05). After adjustment for confounders, the P value for BMD loss (0.03 for LS and 0.04 for FN) did not reach the level of significance required for multiple testing (P = 0.012). No interaction was observed between dietary vitamin K and APOE on BMD.Conclusions: Vitamin K, intake was associated with markers of bone health, but no interaction was observed with APOE alleles on BMD or markers of bone turnover.

AB - Background: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.Objective: We investigated the relation between dietary vitamin K, intake, A POE polymorphisms, and markers of bone health.Design: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) risk and a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.Results: Compared with quartile 3 (Q3) of energy-adjusted vitamin K, intake ((x) over bar: 116 mu g/d), women in the lowest quartile ((x) over bar: 59 mu g/d) had lower BMD (analysis of variance; FN, Q1: 0.831 +/- 0.122 g/cm(2); Q3: 0.850 +/- 0.126 g/cm(2); P < 0.001; LS, Q 1: 1.000 +/- 0.170 g/cm(2); Q3: 1.020 +/- 0.172 g/cm(2); P = 0.009), remaining significant at the FN after adjustment for age, weight, height, menopausal status or use of hormone replacement therapy, socioeconomic status, and physical activity (P = 0.04). Vitamin K, intake was associated with reduced concentrations of pyridinoline crosslinks (Q1: 5.4 +/- 2.0 nmol/mmol; Q4: 5.1 +/- 1.9 nmol/mmol; P = 0.003). Carriers of the E2 allele had greater LS BMD at visit 2 and lost less BMD than did carriers of the E4 allele (E2: -0.50 +/- 1.22%/y; E4: -0.71 +/- 1.17%/y; P = 0.05). After adjustment for confounders, the P value for BMD loss (0.03 for LS and 0.04 for FN) did not reach the level of significance required for multiple testing (P = 0.012). No interaction was observed between dietary vitamin K and APOE on BMD.Conclusions: Vitamin K, intake was associated with markers of bone health, but no interaction was observed with APOE alleles on BMD or markers of bone turnover.

KW - serum undercarboxylated osteocalcin

KW - fracture risk

KW - hip fracture

KW - elderly-men

KW - cholesterol concentrations

KW - premenopausal women

KW - fatty-acids

KW - fruit

KW - supplementation

KW - osteoporosis

M3 - Article

VL - 87

SP - 1513

EP - 1520

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -