TY - JOUR
T1 - What is the effectiveness of surgical and non-surgical therapies in the treatment of ischemic priapism in patients with sickle cell disease? A systematic review by the EAU Sexual and Reproductive Health Panel
AU - Gul, M.
AU - Luca, B.
AU - Dimitropoulos, Konstantinos
AU - Capogrosso, P.
AU - Milenkovic, U.
AU - Cocci, A.
AU - Veeratterapillay, Rajan
AU - Hatzichristodoulou, G.
AU - Modgil, V.
AU - Russo, G. I.
AU - Tharakan, Tharu
AU - Kalkanli , A
AU - Omar, Muhammad Imran
AU - Bettocchi, Carlo
AU - Carvalho, Joana
AU - Corona, Giovanni
AU - Jones, T. H.
AU - Kadioglu, Aras
AU - Martinez-Salamanca, J. I.
AU - Serefoglu, Ege C.
AU - Verze, Paolo
AU - Minhas, S.
AU - Salonia, Andrea
AU - EAU Working Group on Sexual and Reproductive Health
N1 - The authors acknowledge the participants for their cooperation
Conflict of Interest: None of the authors declare any interest.
Formatting of funding sources: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
PY - 2022/6/9
Y1 - 2022/6/9
N2 - Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the occlusion of small blood vessels by sickle-shaped red blood cells. SCD and is associated with a number of complications, including ischemic priapism. While SCD accounts for at least one-third of all priapism cases, no definitive treatment strategy has been established to specifically treat patients with SC priapism. This aim of this systematic review was to assess the efficacy and safety of contemporary treatment modalities for acute and stuttering ischemic priapism associated with SCD. The primary outcome measures were defined as resolution of acute priapism (detumescence) and complete response of stuttering priapism, while the primary harm outcome was as sexual dysfunction. The protocol for the review has been registered (PROSPERO Nr: CRD42020182001), and a systematic search of Medline, Embase, and Cochrane controlled trials databases was performed. Three trials with 41 observational studies met the criteria for inclusion in this review. None of the trials assessed detumescence, as a primary outcome. All of the trials reported a complete response of stuttering priapism; however, the certainty of the evidence was low. It is clear that assessing the effectiveness of specific interventions for priapism in SCD, well-designed, adequately-powered, multicenter trials are strongly required.
AB - Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the occlusion of small blood vessels by sickle-shaped red blood cells. SCD and is associated with a number of complications, including ischemic priapism. While SCD accounts for at least one-third of all priapism cases, no definitive treatment strategy has been established to specifically treat patients with SC priapism. This aim of this systematic review was to assess the efficacy and safety of contemporary treatment modalities for acute and stuttering ischemic priapism associated with SCD. The primary outcome measures were defined as resolution of acute priapism (detumescence) and complete response of stuttering priapism, while the primary harm outcome was as sexual dysfunction. The protocol for the review has been registered (PROSPERO Nr: CRD42020182001), and a systematic search of Medline, Embase, and Cochrane controlled trials databases was performed. Three trials with 41 observational studies met the criteria for inclusion in this review. None of the trials assessed detumescence, as a primary outcome. All of the trials reported a complete response of stuttering priapism; however, the certainty of the evidence was low. It is clear that assessing the effectiveness of specific interventions for priapism in SCD, well-designed, adequately-powered, multicenter trials are strongly required.
KW - Sickle cell disease
KW - ischemic priapism
KW - stuttering priapism
KW - Erectile dysfunction
M3 - Review article
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
SN - 0955-9930
ER -