What is the effectiveness of surgical and non-surgical therapies in the treatment of ischemic priapism in patients with sickle cell disease? A systematic review by the EAU Sexual and Reproductive Health Panel

M. Gul, B. Luca, Konstantinos Dimitropoulos, P. Capogrosso, U. Milenkovic, A. Cocci, Rajan Veeratterapillay, G. Hatzichristodoulou, V. Modgil, G. I. Russo, Tharu Tharakan, A Kalkanli , Muhammad Imran Omar, Carlo Bettocchi, Joana Carvalho, Giovanni Corona, T. H. Jones, Aras Kadioglu, J. I. Martinez-Salamanca, Ege C. SerefogluPaolo Verze, S. Minhas, Andrea Salonia* (Corresponding Author), EAU Working Group on Sexual and Reproductive Health

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the occlusion of small blood vessels by sickle-shaped red blood cells. SCD and is associated with a number of complications, including ischemic priapism. While SCD accounts for at least one-third of all priapism cases, no definitive treatment strategy has been established to specifically treat patients with SC priapism. This aim of this systematic review was to assess the efficacy and safety of contemporary treatment modalities for acute and stuttering ischemic priapism associated with SCD. The primary outcome measures were defined as resolution of acute priapism (detumescence) and complete response of stuttering priapism, while the primary harm outcome was as sexual dysfunction. The protocol for the review has been registered (PROSPERO Nr: CRD42020182001), and a systematic search of Medline, Embase, and Cochrane controlled trials databases was performed. Three trials with 41 observational studies met the criteria for inclusion in this review. None of the trials assessed detumescence, as a primary outcome. All of the trials reported a complete response of stuttering priapism; however, the certainty of the evidence was low. It is clear that assessing the effectiveness of specific interventions for priapism in SCD, well-designed, adequately-powered, multicenter trials are strongly required.
Original languageEnglish
JournalInternational Journal of Impotence Research
Publication statusAccepted/In press - 9 Jun 2022

Keywords

  • Sickle cell disease
  • ischemic priapism
  • stuttering priapism
  • Erectile dysfunction

Fingerprint

Dive into the research topics of 'What is the effectiveness of surgical and non-surgical therapies in the treatment of ischemic priapism in patients with sickle cell disease? A systematic review by the EAU Sexual and Reproductive Health Panel'. Together they form a unique fingerprint.

Cite this