WNT and BMP regulate roadblocks toward cardiomyocyte differentiation

lessons learned from embryos inform human stem cell differentiation

Andrea Münsterberg, Stefan Hoppler

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Abstract

The controlled differentiation of embryonic stem cells into specific cell types holds promise for cell-based therapies in patients, including for the treatment of conditions affecting the heart. In recent years, the isolation of human embryonic stem cells (hESCs), the discovery of ‘induced pluripotency’ and, last but not least, the numerous studies in developing embryos, using model organisms, have brought us closer to the ultimate goal of generating cardiomyocytes in the dish.

With the view to improve existing protocols, a recent study published in Cell Stem Cell (1) has looked in detail at the genome-wide molecular responses triggered by cardiogenic signals in hESCs. In this editorial we will summarize their findings and conclusions and in addition, highlight the seminal discoveries and insights coming from developmental biology that have paved the way. We argue that studying the embryo will continue to make important contributions to stem cell science.
Original languageEnglish
Article number33
Pages (from-to)1-5
Number of pages5
JournalStem Cell Investigation
Volume3
DOIs
Publication statusPublished - 2 Aug 2016

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Cardiac Myocytes
Cell Differentiation
Stem Cells
Embryonic Structures
Developmental Biology
Embryonic Stem Cells
Cell- and Tissue-Based Therapy
Genome
Human Embryonic Stem Cells
Therapeutics

Cite this

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abstract = "The controlled differentiation of embryonic stem cells into specific cell types holds promise for cell-based therapies in patients, including for the treatment of conditions affecting the heart. In recent years, the isolation of human embryonic stem cells (hESCs), the discovery of ‘induced pluripotency’ and, last but not least, the numerous studies in developing embryos, using model organisms, have brought us closer to the ultimate goal of generating cardiomyocytes in the dish.With the view to improve existing protocols, a recent study published in Cell Stem Cell (1) has looked in detail at the genome-wide molecular responses triggered by cardiogenic signals in hESCs. In this editorial we will summarize their findings and conclusions and in addition, highlight the seminal discoveries and insights coming from developmental biology that have paved the way. We argue that studying the embryo will continue to make important contributions to stem cell science.",
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note = "Funding: A M{\"u}nsterberg acknowledges research grant funding from BHF (PG/15/77/31761) and BBSRC (BB/N002326/1). Research in the SH laboratory is supported by BHF (PG/12/75/29851).",
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