Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the Mangrove plant Sonneratia alba

J. Kjer, V. Wray, R. Edrada-Ebel, R. Ebel, A. Pretsch, W. Lin, P. Proksch

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China. The metabolites were confirmed to be of fungal origin, and the structures of the new natural products were unambiguously elucidated on the basis of extensive one- and two-dimensional NMR spectroscopic studies and mass spectrometric analysis. The two new compounds 1 and 2 exhibited weak antibiotic activity against multidrug-resistant Staphylococcus aureus. Altenusin (3) displayed broad antimicrobial activity against several additional multidrug-resistant bacterial and fungal strains.
Original languageEnglish
Pages (from-to)2053-2057
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number11
Early online date16 Oct 2009
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the Mangrove plant Sonneratia alba'. Together they form a unique fingerprint.

  • Cite this