Y chromosome microdeletions in Mexican males of couples with idiopathic recurrent pregnancy loss

Raul Eduardo Pina Aguilar, Sandra G Martínez-Garza, Graciela Kohls, Marco A Vargas-Maciel, Luis G Vázquez de Lara, Claudia González-Ortega, Patricia Cancino-Villarreal, Antonio M Gutiérrez-Gutiérrez

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

AIM: To analyze the presence of Y chromosome microdeletions in males of Mexican couples with idiopathic recurrent pregnancy losses (RPL).

METHODS: Seventy-one males from couples with RPL and 66 fertile males as controls were studied. DNA was isolated from peripheral lymphocytes and used to run multiplex polymerase chain reactions. Regions AZFa (sY84, sY86), AZFb (sY127, sY134) and AZFc (sY254, sY255) of the Y chromosome were analyzed according to valid guidelines recommended by the European Academy of Andrology and the European Molecular Genetics Quality Network. Also, the sequence tagged sites (STSs): DYS262 (sY67), DYS220 (sY129), DYF85S1 (sY150), DYF86S1 (sY152) and DYF87S1 (sY153) were included in order to analyze STSs previously reported as deleted. A power analysis to support our simple size was performed.

RESULTS: Results show an absence of Y chromosome microdeletions in males of couples with RPL and controls with an acceptable statistical power.

CONCLUSION: The study did not show an association of recurrent pregnancy loss and Y chromosome microdeletions in Mexican male partners. Based on the results, the study of Y chromosome microdeletions in couples with RPL is not considered clinically relevant.

Original languageEnglish
Pages (from-to)912-917
Number of pages6
JournalJournal of Obstetrics and Gynaecology
Volume38
Issue number6
Early online date9 Apr 2012
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Abortion, Habitual
  • Adult
  • Chromosome Deletion
  • Chromosomes, Human, Y
  • Family Characteristics
  • Female
  • Genetic Testing
  • Humans
  • Male
  • Mexico
  • Middle Aged
  • Pregnancy
  • Sex Chromosome Aberrations
  • Sex Chromosome Disorders of Sex Development
  • Young Adult
  • Journal Article

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  • Cite this

    Pina Aguilar, R. E., Martínez-Garza, S. G., Kohls, G., Vargas-Maciel, M. A., Vázquez de Lara, L. G., González-Ortega, C., Cancino-Villarreal, P., & Gutiérrez-Gutiérrez, A. M. (2012). Y chromosome microdeletions in Mexican males of couples with idiopathic recurrent pregnancy loss. Journal of Obstetrics and Gynaecology, 38(6), 912-917. https://doi.org/10.1111/j.1447-0756.2011.01809.x