Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats

Young-Eun Cho, Ria-Ann R Lomeda, Sang-Hoon Ryu, Ho-Yong Sohn, Hong-In Shin, John H Beattie, In-Sook Kwun

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    Zn is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth, and reproduction. The present study evaluated whether Zn deficiency would negatively affect bone-related enzyme, ALP, and other bone-related minerals (Ca, P and Mg) in rats. Thirty Sprague Dawley rats were assigned to one of the three different Zn dietary groups, such as Zn adequate (ZA, 35 mg/kg), pair fed (PF, 35 mg/kg), Zn deficient (ZD, 1 mg/kg) diet, and fed for 10 weeks. Food intake and body weight were measured daily and weekly, respectively. ALP was measured by spectrophotometry and mineral contents were measured by inductively coupled plasma-mass spectrophotometer (ICP-MS). Zn deficient rats showed decreased food intake and body weight compared with Zn adequate rats (p
    Original languageEnglish
    Pages (from-to)113-119
    Number of pages7
    JournalNutrition Research and Practice
    Issue number2
    Publication statusPublished - 2007



    • zinc
    • alkaline phosphatase
    • bone-related minerals (Ca, P, Mg)
    • rats

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