• 1674 Citations
1993 …2020

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2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., Fleming, I. N., Green, S. R., McNae, I., Wu, S-Y., McInnes, C., Zheleva, D., Walkinshaw, M. D. & Fischer, P. M., 25 Mar 2004, In : Journal of Medicinal Chemistry. 47, 7, p. 1662-1675 14 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions

Thompson, S., Zhang, Q., Onega, M., McMahon, S., Fleming, I., Ashworth, S., Naismith, J. H., Passchier, J. & O'Hagan, D., 18 Aug 2014, In : Angewandte Chemie International Edition. 53, 34, p. 8913-8918 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

Thompson, S., Onega, M., Ashworth, S., Fleming, I. N., Passchier, J. & O'Hagan, D., 2015, In : Chemical Communications. 51, 70, p. 13542-13545 4 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
7 Downloads (Pure)
Open Access
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10 Citations (Scopus)
9 Downloads (Pure)

Building PET research collaborations

Fleming, I. N., Gilbert, F. J. & Blower, P. J., Jan 2012, In : Nuclear Medicine Communications. 33, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

Fleming, I. N., Elliott, C. M., Buchanan, F. G., Downes, C. P. & Exton, J. H., 1999, In : The Journal of Biological Chemistry. 274, 18, p. 12753-8 6 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)
Open Access
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10 Citations (Scopus)
12 Downloads (Pure)

Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types

Green, S. R., Choudhary, A. K. & Fleming, I. N., Nov 2010, In : British Journal of Cancer. 103, 9, p. 1391-1399 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery

Piras, M., Andriu, A., Testa, A., Wienecke, P., Fleming, I. N. & Zanda, M., 2017, In : Synlett. 28, 20, p. 2769-2776 8 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
7 Downloads (Pure)

Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

Watt, S. A., Kimber, W. A., Fleming, I. N., Leslie, N. R., Downes, C. P. & Lucocq, J. M., 1 Feb 2004, In : Biochemical Journal. 377, 3, p. 653-663 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Determination of interaction sites on the small G protein RhoA for phospholipase D

Bae, C. D., Min, D. S., Fleming, I. N. & Exton, J. H., 1998, In : The Journal of Biological Chemistry. 273, 19, p. 11596-604 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor

Fleming, I. N., Elliott, C. M. & Exton, J. H., 1996, In : The Journal of Biological Chemistry. 271, 51, p. 33067-73 7 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)
Open Access
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11 Citations (Scopus)
8 Downloads (Pure)

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor

Dall'angelo, S., Zhang, Q., Fleming, I. N., Piras, M., Schweiger, L. F., O'Hagan, D. & Zanda, M., 3 Jun 2013, In : Organic & Biomolecular Chemistry. 27, 11, p. 4551-4558 8 p.

Research output: Contribution to journalArticle

Open Access
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42 Downloads (Pure)

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M. & O'Hagan, D., 2019, In : Organic & Biomolecular Chemistry. 17, 6, p. 1480-1486 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
3 Downloads (Pure)

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

Thompson, S., Fleming, I. N. & O’Hagan, D., 21 Mar 2016, In : Organic & Biomolecular Chemistry. 14, 11, p. 3120-3129 10 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
7 Downloads (Pure)

High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J. & Zanda, M., 20 Jul 2017, In : ChemMedChem. 12, 14, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
10 Downloads (Pure)

Hypoxia PET/CT and Colorectal Cancer: A Case Report

Laws, K., Murray, G. I., Kerr, K., McKiddie, F., Dall'angelo, S., Zanda, M., Fleming, I. & Samuel, L., 12 Aug 2020, In : Journal of Case Reports and Images in Oncology. 1(1), 2-5, 5 p.

Research output: Contribution to journalArticle

Open Access
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Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase

Smith, T. A. D., Zanda, M. & Fleming, I. N., Aug 2013, In : Nuclear Medicine and Biology. 40, 6, p. 858-864 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Fleming, I. N., Batty, I. H., Prescott, A. R., Gray, A., Kular, G. S., Stewart, H. & Downes, C. P., 15 Sep 2004, In : Biochemical Journal. 382, 3, p. 857-865 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

Lazzari, P., Spiga, M., Sani, M., Zanda, M. & Fleming, I. N., 23 May 2017, In : Hypoxia. 5, p. 45-59 15 p.

Research output: Contribution to journalArticle

Open Access
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9 Downloads (Pure)

Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M. & O'Hagan, D., 25 Jul 2016, In : Chemistry : a European Journal. 22, 31, p. 10998-11004 7 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
7 Downloads (Pure)

Linear Trifluoroethylamine RGD Peptidomimetics: Stereoselective Synthesis and Integrin alphavbeta3 affinity

Piras, M., Fleming, I. N., Harrison, W. T. A. & Zanda, M., 2012, In : Synlett. 23, 20, p. 2899-2902 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C

Fleming, I. N., Elliott, C. M., Collard, J. G. & Exton, J. H., 1997, In : The Journal of Biological Chemistry. 272, 52, p. 33105-10 6 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles

Testa, A., Piras, M., Hickey, M. J., Fleming, I. N., Bushby, N., Lenz, E., Elmore, C. S. & Zanda, M., Apr 2014, In : Synlett. 25, 07, p. 1019-1025 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
17 Citations (Scopus)

NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M. & Piras, M., 18 May 2016, In : Bioconjugate Chemistry. 27, 5, p. 1332-1340 9 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
7 Downloads (Pure)

Opportunities for PET to deliver clinical benefit in cancer: breast cancer as a paradigm

Fleming, I. N., Gilbert, F. J., Miles, K. A. & Cameron, D., 6 Jul 2010, In : Cancer Imaging. 10, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Partial purification of cell-signalling phosphatidic acid phosphohydrolase from rat liver

Fleming, I. N. & Yeaman, S. J., 1993, In : Biochemical Society Transactions. 21, 4, p. 366S

Research output: Contribution to journalArticle

37 Citations (Scopus)

Positron emission tomography oncology research in the UK: a comparison with USA and Europe

Fleming, I. N., Regel, S. J., Pike, L. C., Marsden, P. K. & Gilbert, F. J., Apr 2012, In : Nuclear Medicine Communications. 33, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers

Fleming, I. N., Whelan, M., Baxendale, R., Gilbert, F. J., Matthews, P. P. & Aigbirhio, F. I., Sep 2012, In : Nuclear Medicine Communications. 33, 9, p. 899-906 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

Phyu, S. M., Tseng, C-C. T., Fleming, I. N. & Smith, T. A. D., 4 Nov 2016, In : Scientific Reports. 6, 36544.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
7 Downloads (Pure)

Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

Fleming, I. N. & Yeaman, S. J., 1995, In : Biochemical Journal. 308 ( Pt 3), p. 983-9 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

Aboagye, E. O., Gilbert, F. J., Fleming, I. N., Beer, A. J., Cunningham, V. J., Marsden, P. K., Visvikis, D., Gee, A. D., Groves, A. M., Kenny, L. M., Cook, G. J., Kinahan, P. E., Myers, M., Clarke, L. & Experimental Cancer Medicine Centre 13 Imaging Network Group, 1 Jul 2012, In : European Radiology. 22, 7, p. 1465-1478 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

Fleming, I. N., Gray, A. & Downes, C. P., 2000, In : Biochemical Journal. 351, Pt 1, p. 173-82 10 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR detectable phosphomonesters

Smith, T. A. D., Appleyard, M. V. C. L., Sharp, S., Fleming, I. N., Murray, K. & Thompson, A. M., Feb 2013, In : Cancer Chemotherapy and Pharmacology. 71, 2, p. 473-480 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
17 Citations (Scopus)

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P. & Lucocq, J. M., 2002, In : Biochemical Journal. 363, Pt 3, p. 657-66 10 p.

Research output: Contribution to journalArticle

282 Citations (Scopus)

Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents

Fleming, I. N., Hogben, M., Frame, S., McClue, S. J. & Green, S. R., 2008, In : Clinical Cancer Research. 14, 13, p. 4326-4335 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

Nortcliffe, A., Fleming, I. N., Botting, N. P. & O'Hagan, D., 4 Nov 2014, In : Tetrahedron. 70, 44, p. 8343-8347 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings

Day, C. P., James, O. F., Brown, A. S., Bennett, M. K., Fleming, I. N. & Yeaman, S. J., 1993, In : Hepatology. 18, 4, p. 832-8 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

Downes, C. P., Gray, A., Fairservice, A., Safrany, S. T., Batty, I. H. & Fleming, I. N., Dec 2005, In : Biochemical Society Transactions. 33, Pt 6, p. 1303-1307 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2

Lamidi, O., Sani, M., Lazzari, P., Zanda, M. & Fleming, I. N., Sep 2015, In : Journal of Cancer Research and Clinical Oncology. 141, 9, p. 1575-1583 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., McKiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M. & 1 others, Petty, R. D., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1525-1534 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

Hernandez Gerez, E., Dall'angelo, S., Collinson, J. M., Fleming, I. N. & Parson, S. H., Sep 2020, In : Annals of Clinical and Translational Neurology. 7, 9, p. 1580-1593 14 p.

Research output: Contribution to journalArticle

Open Access
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