Mairi McLean

Research output

Research output per year 2005 2011 2014 2016 2017 2018 2022

• 25 Article
• 3 Abstract
• 3 Editorial
• 3 Review article
• 4 More
  • 2 Chapter
  • 1 Commissioned Report
  • 1 Literature review

Research output per year

Research output per year

Search results

• 2022

  Hyposplenism and gastrointestinal diseases: significance and mechanisms

  Mathur, A., McLean, M. H., Cao, H. & Vickers, M. A., May 2022, In: Digestive Diseases. 40, p. 290–298 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Gastrointestinal Diseases 100%
  • Patient Education 48%
  • Infections 44%
  • Inflammatory Bowel Diseases 44%
  • Abdomen 42%
  5 Citations (Scopus)

  2 Downloads (Pure)

• Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model

  Brice, D. P., Murray, G. I., Wilson, H. M., Porter, R. J., Berry, S., Durum, S. K. & McLean, M. H., 11 Mar 2022, In: Biology. 11, 3, 16 p., 427.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-27 100%
  • Organoids 88%
  • interleukins 80%
  • Permeability 53%
  • tissues 30%
  6 Citations (Scopus)

  4 Downloads (Pure)
• 2021

  Colonic epithelial cathelicidin (LL-37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate

  Porter, R. J., Murray, G., Alnabulsi, A., Humphries, M. P., James, J. A., Salto-Tellez, M., Craig, S. G., Wang, J. M., Yoshimura, T. & McLean, M., 1 Sept 2021, In: The Journal of Pathology. Clinical Research. 7, 5, p. 495-506 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • CAP18 lipopolysaccharide-binding protein 100%
  • Colorectal Neoplasms 55%
  • T-Lymphocytes 43%
  • DNA Mismatch Repair 20%
  • Neoplasms 14%
  7 Citations (Scopus)

  3 Downloads (Pure)
• 2020

  Current concepts in tumour-derived organoids

  Porter, R. J., Murray, G. & McLean, M. H., 13 Oct 2020, In: British Journal of Cancer. 123, p. 1209-1218 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Organoids 100%
  • Neoplasms 24%
  • Induced Pluripotent Stem Cells 10%
  • Embryonic Stem Cells 10%
  • Tumor Microenvironment 9%
  49 Citations (Scopus)

  6 Downloads (Pure)

• Novel biomarkers for risk stratification of Barrett’s oesophagus associated neoplastic progression–epithelial HMGB1 expression and stromal lymphocytic phenotype

  Porter, R. J., Murray, G. I., Price, D. P., Petty, R. D. & McLean, M. H., 18 Feb 2020, In: British Journal of Cancer. 122, p. 545-554 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • HMGB1 Protein 100%
  • Barrett Esophagus 90%
  • Biomarkers 49%
  • Phenotype 45%
  • Adenocarcinoma 44%
  15 Citations (Scopus)

  7 Downloads (Pure)
• 2019

  P615 Rescue infliximab for acute severe colitis: a single-centre experience

  Orpen-Palmer, J., Clegg, F., Basavaraju, U., Bain, G. H., Parnaby, C. N., Smith, M. G., McLean, M. H. & Thomson, J. M., Mar 2019, In: Journal of Crohn's and Colitis. 13, Supplement_1, p. S424-S424 1 p.

  Research output: Contribution to journal › Abstract › peer-review

  • Infliximab 100%
  • Colitis 87%
  • Inflammatory Bowel Diseases 70%
  • Colectomy 23%
  • Ulcerative Colitis 21%
  53 Citations (Scopus)
• 2018

  Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease?

  Porter, R. J., Andrews, C., Brice, D. P., Durum, S. K. & McLean, M. H., 15 Sept 2018, In: Inflammatory Bowel Diseases. 24, 10, p. 2123-2134 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Inflammatory Bowel Diseases 100%
  • Anti-Inflammatory Agents 77%
  • Long Term Adverse Effects 18%
  • Therapeutics 17%
  • Endocannabinoids 16%
  8 Citations (Scopus)

  11 Downloads (Pure)

• Cytokine Tuning of Intestinal Epithelial Function

  Andrews, C., McLean, M. H. & Durum, S. K., 5 Jun 2018, In: Frontiers in Immunology. 9, 1270.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytokines 100%
  • Intestinal Mucosa 85%
  • Chemokines 50%
  • Intestines 48%
  • Epithelial Cells 38%
  187 Citations (Scopus)

  10 Downloads (Pure)

• The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–Like Ileitis

  Rodriguez-Palacios, A., Harding, A., Menghini, P., Himmelman, C., Retuerto, M., Nickerson, K. P., Lam, M., Croniger, C. M., McLean, M. H., Durum, S. K., Pizarro, T. T., Ghannoum, M. A., Ilic, S., McDonald, C. & Cominelli, F., May 2018, In: Inflammatory Bowel Diseases. 24, 5, p. 1005-1020 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • trichlorosucrose 100%
  • Ileitis 90%
  • Sweetening Agents 82%
  • Proteobacteria 81%
  • Dysbiosis 74%
  135 Citations (Scopus)

  9 Downloads (Pure)

• 21. Gastroenterology

  El-Omar, E., Clegg, C. F. & McLean, M. H., 30 Apr 2018, Davidson's Self-assessment in Medicine. Wake, D. & Cantley, P. (eds.). 1 ed. Elsevier, p. 225-244 20 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • textbook 100%
  • medicine 85%
  • medical practice 42%
  • efficiency 27%
  • examination 22%

• The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance

  Yoshimura, T., McLean, M. H., Dzutsev, A. K., Yao, X., Chen, K., Huang, J., Gong, W., Zhou, J., Xiang, Y., Badger, J., Ohuigin, C., Thovarai, V., Tessarollo, L., Durum, S. K., Trinchieri, G., Bian, X. & Wang, J. M., 15 Mar 2018, In: The Journal of Immunology. 200, 6, p. 2174-2185 12 p.

  Research output: Contribution to journal › Article › peer-review

  • CAP18 lipopolysaccharide-binding protein 100%
  • Microbiota 68%
  • Colon 55%
  • Homeostasis 51%
  • Peptides 44%
  55 Citations (Scopus)
• 2017

  Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10–Dependent, T-Cell–Independent Attenuation of Colonic Mucosal Innate Immune Responses

  McLean, M. H., Andrews, C., Hanson, M. L., Baseler, W. A., Anver, M. R., Senkevitch, E., Staniszewska, A. K., Davies, L. C., Hixon, J., Li, W., Shen, W., Steidler, L. & Durum, S. K., Nov 2017, In: Inflammatory Bowel Diseases. 23, 11, p. 1983-1995 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-27 100%
  • Mucosal Immunity 84%
  • Interleukins 74%
  • Colitis 69%
  • Innate Immunity 62%
  26 Citations (Scopus)

  9 Downloads (Pure)

• Teduglutide for treating short bowel syndrome

  Scotland, G., Kopasker, D., Scott, N., Cruickshank, M., Hernández, R. A., Fraser, C. M., McLean, M., McKinlay, A. & Brazzelli, M., 20 Sept 2017, Evidence Review Group report in support of NICE STA Programme. London: National Institute for Health and Care Excellence. 142 p.

  Research output: Book/Report › Commissioned Report

  • teduglutide 100%
  • Short Bowel Syndrome 73%
  • Glucagon-Like Peptide 2 16%
  • Catheter-Related Infections 13%
  • Parenteral Nutrition 12%

• GI highlights from the literature

  McLean, M. H., 1 Aug 2017, In: Gut. 66, 8, p. 1528-1529 2 p.

  Research output: Contribution to journal › Article

• GI highlights from the literature: Gut, Volume 66, p1341-1342

  McLean, M. H., 1 Jul 2017, In: Gut. 66, 7, p. 1341-1342 2 p.

  Research output: Contribution to journal › Editorial

• GI highlights from the literature: Gut, Volume 66, Issue 3

  McLean, M. H., Mar 2017, In: Gut. 66, 3, p. 975-976 2 p.

  Research output: Contribution to journal › Editorial

  Open Access

  • Microbiota 100%
• 2016

  Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature

  Andrews, C., McLean, M. H. & Durum, S. K., Sept 2016, In: Inflammatory Bowel Diseases. 22, 9, p. 2255-2264 10 p.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File

  • Interleukin-27 100%
  • Inflammatory Bowel Diseases 63%
  • Cytokines 13%
  • Interleukin Receptors 11%
  • Therapeutics 11%
  42 Citations (Scopus)

  29 Downloads (Pure)

• IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice

  Shen, W., Hixon, J. A., McLean, M. H., Li, W. Q. & Durum, S. K., 19 Jan 2016, In: Frontiers in Immunology. 6, 14 p., 662.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • interleukin-22 100%
  • Virulence 64%
  • Lymphocytes 51%
  • T-Lymphocytes 24%
  • Interleukin-17 21%
  17 Citations (Scopus)

  7 Downloads (Pure)

• Influence of host gene polymorphisms on development of gastroduodenal diseases

  McLean, M. H., Nicoll, R., Saw, C., Hold, G. L. & El-Omar, E. M., 1 Jan 2016, Helicobacter pylori Research: From Bench to Bedside. Backert, S. & Yamaoka, Y. (eds.). 1 ed. Springer Japan, p. 339-362 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Helicobacter pylori 100%
  • Stomach Neoplasms 53%
  • Genes 49%
  • Gastritis 44%
  • Peptic Ulcer 44%
• 2015

  Does the microbiota play a role in the pathogenesis of autoimmune diseases?

  McLean, M. H., Dieguez, D., Miller, L. M. & Young, H. A., 8 Aug 2015, In: Gut. 64, 2, p. 332-341 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Microbiota 100%
  • Autoimmune Diseases 87%
  • Dysbiosis 18%
  • Disease Susceptibility 15%
  • Celiac Disease 15%
  175 Citations (Scopus)
• 2014

  Genetics of gastric cancer

  McLean, M. H. & El-Omar, E. M., Nov 2014, In: Nature Reviews Gastroenterology & Hepatology. 11, 11, p. 664-674 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Stomach Neoplasms 100%
  • Chromosomal Instability 23%
  • Microsatellite Instability 23%
  • MicroRNAs 16%
  • Single Nucleotide Polymorphism 16%
  332 Citations (Scopus)

• Targeting interleukins for the treatment of inflammatory bowel disease: What lies beyond anti-TNF therapy?

  McLean, M. H., Neurath, M. F. & Durum, S. K., Feb 2014, In: Inflammatory Bowel Diseases. 20, 2, p. 389-397 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukins 100%
  • Inflammatory Bowel Diseases 86%
  • Interleukin-27 33%
  • Interleukin-33 31%
  • interleukin-22 30%
  39 Citations (Scopus)

• Oral Delivery of IL-27 Recombinant Bacteria Attenuates Immune Colitis in Mice

  Hanson, M. L., Hixon, J. A., Li, W., Felber, B. K., Anver, M. R., Stewart, C. A., Janelsins, B. M., Datta, S. K., Shen, W., McLean, M. H. & Durum, S. K., Jan 2014, In: Gastroenterology. 146, 1, p. 210-221.e13 25 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-27 100%
  • Colitis 69%
  • Bacteria 45%
  • Interleukin-10 13%
  • T-Lymphocytes 12%
  138 Citations (Scopus)
• 2013

  Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?

  McLean, M. H., Thomson, A. J., Murray, G. I., Fyfe, N., Hold, G. L. & El-Omar, E. M., 25 Jun 2013, In: British Journal of Cancer. 108, 12, p. 2537-2541 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lipocalin-2 100%
  • Adenoma 58%
  • Adenomatous Polyps 33%
  • Disease Progression 29%
  • Mucous Membrane 29%
  19 Citations (Scopus)

  35 Downloads (Pure)
• 2012

  Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps-a putative role of semaphorins 3F and 3A

  Graf, N., McLean, M. H., Capellino, S., Scholmerich, J., Murray, G. I., El-Omar, E. M. & Straub, R. H., Feb 2012, In: Neurogastroenterology and Motility. 24, 2, p. 120-e83 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Semaphorins 100%
  • Adenomatous Polyps 93%
  • Polyps 71%
  • Substance P 62%
  • Nerve Fibers 56%
  8 Citations (Scopus)
• 2011

  Genetics of inflammation in the gastrointestinal tract and how it can cause cancer.

  McLean, M. H. & El-Omar, E. M., 6 Aug 2011, In: Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer. 185, p. 173-183 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Gastrointestinal Tract 100%
  • Inflammation 67%
  • Molecular Epidemiology 67%
  • Neoplasms 37%
  • Pylorus 32%
  21 Citations (Scopus)

• Enterohepatic Helicobacter in ulcerative colitis: potential pathogenic entities?

  Thomson, J. M., Hansen, R., Berry, S. H., Hope, M. E., Murray, G. I., Mukhopadhya, I., McLean, M. H., Shen, Z., Fox, J. G., El-Omar, E. & Hold, G. L., 23 Feb 2011, In: PloS ONE. 6, 2, 9 p., e17184.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Helicobacter 100%
  • Ulcerative Colitis 70%
  • Polymerase Chain Reaction 33%
  • Pylorus 18%
  • Oligonucleotide Probes 10%
  76 Citations (Scopus)

  7 Downloads (Pure)

• The inflammatory microenvironment in colorectal neoplasia

  McLean, M. H., Murray, G. I., Stewart, K. N., Norrie, G., Mayer, C., Hold, G. L., Thomson, J., Fyfe, N., Hope, M., Mowat, N. A. G., Drew, J. E. & El-Omar, E. M., 7 Jan 2011, In: PloS ONE. 6, 1, 8 p., e15366.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenoma 100%
  • Colonic Polyps 51%
  • Adenomatous Polyps 47%
  • Macrophages 37%
  • Neoplasms 34%
  147 Citations (Scopus)

  10 Downloads (Pure)
• 2010

  Esophageal Cancers and Helicobacter pylori: Do Host Genes Matter?

  McLean, M. H. & El-Omar, E. M., 1 Jul 2010, In: Gastroenterology. 139, 1, p. 17-19 3 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Citation (Scopus)

• Increase in NF-κB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease

  Ng, M. T. H., Van't Hof, R., Crockett, J. C., Hope, M. E., Berry, S., Thomson, J., McLean, M. H., McColl, K. E. L., El-Omar, E. M. & Hold, G. L., Mar 2010, In: Infection and Immunity. 78, 3, p. 1345-1352 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Toll-like receptor 9 100%
  • Toll-Like Receptor 9 78%
  • Stomach Diseases 75%
  • gastrointestinal diseases 70%
  • Helicobacter pylori 67%
  83 Citations (Scopus)
• 2009

  Genetic aspects of inflammation

  McLean, M. H. & El-Omar, E. M., Aug 2009, In: Current Opinion in Pharmacology. 9, 4, p. 370-374 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammation 100%
  • Host Microbial Interactions 53%
  • Molecular Epidemiology 49%
  • Environmental Exposure 46%
  • Helicobacter pylori 41%
  8 Citations (Scopus)

• The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers

  Jeffery, N., McLean, M. H., El-Omar, E. M. & Murray, G. I., Jun 2009, In: Histopathology. 54, 7, p. 820-828 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Tissue Inhibitor of Metalloproteinases 100%
  • Matrix Metalloproteinase Inhibitors 90%
  • Polyps 76%
  • Matrix Metalloproteinases 72%
  • Colorectal Neoplasms 60%
  36 Citations (Scopus)
• 2008

  Role of chronic inflammation in sporadic colorectal neoplasia

  McLean, M. H., Murray, G. I., Stewart, K. N., Hold, G. L., Fyfe, N., Mowat, N. A. G. & El-Omar, E. M., Apr 2008, In: Gastroenterology. 134, 4 Supplement 1, p. A293-A294 2 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Assessment of inflammatory cell phenotype in sporadic hyperplastic polyps

  McLean, M. H., Murray, G. I., Fyfe, N., Hold, G. L., Mowat, A. G. & El-Omar, E. M., Apr 2007, In: Gut. 56, Suppl 2, p. A51-A51 1 p., 154.

  Research output: Contribution to journal › Abstract › peer-review

• Assessment of macrophage function within the stroma of sporadic colorectal polyps

  McLean, M. H., Murray, G. I., Fyfe, N., Hold, G. L., Mowat, A. G. & El-Omar, E. M., Apr 2007, In: Gut. 56, Suppl 2, p. A51-A51 1 p., 153.

  Research output: Contribution to journal › Abstract › peer-review
• 2006

  Assessment of inflammation within sporadic colorectal polyps

  McLean, M. H., Murray, G. I., Fyfe, N., Hold, G. L., Mowat, A. G. & El-Omar, E. M., Apr 2006, In: Gut. 55, Suppl. 2, p. A23 1 p.

  Research output: Contribution to journal › Article › peer-review

• Expression of cyclooxygenase-2 in human sporadic colorectal adenomas

  McLean, M. H., Murray, G. I., Fyfe, N., Hold, G. L., Mowat, A. G. & El-Omar, E. M., Apr 2006, In: Gut. 55, Suppl. 2, p. A23-A24 2 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  COX-2 gene polymorphisms and association with premalignant changes in the stomach

  Smith, M. G., Hold, G. L., MacArthur, M., McLean, M. H., Hope, M., Mowat, A. G., McColl, K. E. & El-Omar, E. M., Apr 2005, In: Gut. 54, Suppl. 2, 2 p.

  Research output: Contribution to journal › Article › peer-review