• 1609 Citations
1991 …2020

Research output per year

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Research Output

2020

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

McEwan, A. R., Davidson, C., Hay, E., Turnbull, Y., Erickson, J. C., Marini, P., Wilson, D., McIntosh, A., Adams, M. J., Murgatroyd, C., Barrett, P., Delibegovic, M., Clarke, T-K. & MacKenzie, A., 13 Mar 2020, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4

Sergi, D., Morris, A. C., Kahn, D. E., McLean, F. H., Hay, E. A., Kubitz, P., MacKenzie, A., Martinoli, M. G., Drew, J. E. & Williams, L. M., 2020, In : Nutritional Neuroscience. 23, 4, p. 321-334 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2019
Open Access
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4 Citations (Scopus)
4 Downloads (Pure)

Early and reversible changes to the hippocampal proteome in mice on a high-fat diet

McLean, F. H., Campbell, F. M., Sergi, D., Grant, C., Morris, A. C., Hay, E. A., MacKenzie, A., Mayer, C-D., Langston, R. F. & Williams, L. M., Dec 2019, In : Nutrition and Metabolism. 16, 1, 12 p., 57.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
3 Downloads (Pure)
2017

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

Hay, E. A., Khalaf, A. R., Marini, P., Brown, A., Heath, K., Sheppard, D. & MacKenzie, A., Aug 2017, In : Neuropeptides. 64, p. 101-107 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
6 Downloads (Pure)

Neuropeptides-2015, Aberdeen University, Scotland

MacKenzie, A., Pinter, E. & Quinn, J., Aug 2017, In : Neuropeptides. 64, p. 1 1 p.

Research output: Contribution to journalArticle

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation

Hay, E. A., Knowles, C., Kolb, A. & MacKenzie, A., Aug 2017, In : Neuropeptides. 64, p. 19-25 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
8 Downloads (Pure)
2016

Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones

Davidson, S., Shanley, L., Cowie, P., Lear, M., McGuffin, P., Quinn, J. P., Barrett, P. & MacKenzie, A., Aug 2016, In : The Pharmacogenomics Journal. 16, 4, p. 366-374 9 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
6 Downloads (Pure)
2015
Open Access
File
7 Citations (Scopus)
4 Downloads (Pure)

Determining Epigenetic Targets: A Beginner's Guide to Identifying Genome Functionality Through Database Analysis

Hay, E. A., Cowie, P. & MacKenzie, A., 2015, In : Methods in Molecular Biology. 1589, p. 29-45 17 p.

Research output: Contribution to journalArticle

The noncoding human genome and the future of personalised medicine

Cowie, P., Hay, E. A. & MacKenzie, A., 2015, In : Expert Reviews in Molecular Medicine. 17, 20 p., e4.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2014

Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes

Richardson, T. G., Minica, C., Heron, J., Tavare, J., MacKenzie, A., Day, I., Lewis, G., Hickman, M., Vink, J. M., Gelernter, J., Kranzler, H. R., Farrer, L. A., Munafò, M. & Wynick, D., Dec 2014, In : American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 165, 8, p. 654-664 11 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
6 Downloads (Pure)

Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

Hay, C., Shanley, L., Davidson, S., Cowie, P., Lear, M., McGuffin, P., Riedel, G., McEwan, I. J. & MacKenzie, A., Sep 2014, In : Psychoneuroendocrinology. 47, p. 43-55 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
6 Downloads (Pure)

In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

Fowler, P. A., Childs, A. J., Courant, F., MacKenzie, A., Rhind, S. M., Antignac, J-P., Le Bizec, B., Filis, P., Evans, F., Flannigan, S., Maheshwari, A., Bhattacharya, S., Monteiro, A., Anderson, R. A. & O'Shaughnessy, P. J., Jul 2014, In : Human Reproduction. 29, 7, p. 1471-1489 19 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR

Hay, C. W., Watt, K., Hunter, I., Lavery, D. N., MacKenzie, A. & McEwan, I. J., Oct 2014, In : Hormones and Cancer. 5, 5, p. 299-311 13 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
6 Downloads (Pure)
2013

Exploring the effects of polymorphisms on cis-regulatory signal transduction response

MacKenzie, A., Hing, B. & Davidson, S., Feb 2013, In : Trends in Molecular Medicine. 19, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
5 Downloads (Pure)

Understanding the Dynamics of Gene Regulatory Systems: Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

Cowie, P. D., MacKenzie, A. & Ross, R., 9 Jan 2013, In : Biology. 2, 1, p. 64-84 20 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
6 Downloads (Pure)
2012

Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus

Nicoll, G., Davidson, S., Shanley, L., Hing, B., Lear, M., McGuffin, P., Ross, R. & MacKenzie, A., 13 Apr 2012, In : The Journal of Biological Chemistry. 287, 16, p. 12828-12834 7 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
6 Downloads (Pure)

A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity

Hing, B., Davidson, S., Lear, M., Breen, G., Quinn, J., McGuffin, P. & MacKenzie, A., 1 Apr 2012, In : Biological Psychiatry. 71, 7, p. 618-626 9 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
5 Downloads (Pure)
2011

Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism

Davidson, S., Lear, M., Shanley, L., Hing, B., Baizan-Edge, A., Herwig, A., Quinn, J. P., Breen, G., McGuffin, P., Starkey, A., Barrett, P. & Mackenzie, A., Oct 2011, In : Neuropsychopharmacology. 36, 11, p. 2211-2221 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones

Shanley, L., Lear, M., Davidson, S., Ross, R. A. & MacKenzie, A., 2011, In : Journal of Neuroinflammation. 8, -, 10 p., 10.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
5 Downloads (Pure)
2010

Genome-wide association study of major recurrent depression in the U.K. population

Lewis, C. M., Ng, M. Y., Butler, A. W., Cohen-Woods, S., Uher, R., Pirlo, K., Weale, M. E., Schosser, A., Paredes, U. M., Rivera, M., Craddock, N., Owen, M. J., Jones, L., Jones, I., Korszun, A., Aitchison, K. J., Shi, J., Quinn, J. P., MacKenzie, A., Vollenweider, P. & 13 others, Waeber, G., Heath, S., Lathrop, M., Muglia, P., Barnes, M. R., Whittaker, J. C., Tozzi, F., Holsboer, F., Preisig, M., Farmer, A. E., Breen, G., Craig, I. W. & McGuffin, P., 1 Jun 2010, In : American Journal of Psychiatry. 167, 8, p. 949-957 9 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones

Shanley, L., Davidson, S., Lear, M., Thotakura, A. K., McEwan, I. J., Ross, R. A. & Mackenzie, A., 2010, In : Neuro-Signals. 18, 3, p. 173-185 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009
Open Access
File
18 Citations (Scopus)
9 Downloads (Pure)
2008

Prediction and characterisation of a highly conserved, remote and cAMP responsive enhancer that regulates Msx1 gene expression in cardiac neural crest and outflow tract

Miller, K. A., Davidson, S., Liaros, A., Barrow, J., Lear, M., Heine, D., Hoppler, S. & MacKenzie, A., 15 May 2008, In : Developmental Biology. 317, 2, p. 686-694 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2007

A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells

Miller, K. A., Barrow, J., Collinson, J. M., Davidson, S., Lear, M., Hill, R. E. & MacKenzie, A., 15 Nov 2007, In : Developmental Biology. 311, 2, p. 665-678 14 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Closing the systems biology validation gap – comparative genomics and depressive disease

Barrow, J., Davidson, S., Lear, M. & MacKenzie, A., 2007.

Research output: Contribution to conferencePoster

Generation of a transgenic model to address regulation and function of the human neurokinin 1 receptor (NK1R)

Vasiliou, A. S., MacKenzie, A., Morris, R., McLaughlin, L., Bubb, V. J., Haddley, K. & Quinn, J. P., Aug 2007, In : Neuropeptides. 41, 4, p. 195-205 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2006

Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice

Lang, B., Song, B., Davidson, W., MacKenzie, A., Smith, N., McCaig, C. D., Harmar, A. J. & Shen, S., 3 Jul 2006, In : The Journal of Clinical Investigation. 116, 7, p. 1924-1934 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Postgenomic bioinformatic analysis of yeast artificial chromosome sequence

Miller, K. A., Davidson, S. & MacKenzie, A., 18 Aug 2006, YAC Protocols. MacKenzie, A. (ed.). 2 ed. Totowa, NJ, USA: Humana Press, Vol. 349. p. 41-59 349 p. (Methods in Molecular Biology; vol. 349).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Transcription Factor-DNA Interactions at the Substance P Enhancer, ECR1

Barrow, J. & MacKenzie, A., 6 Jun 2006.

Research output: Contribution to conferenceAbstract

2005

Purification and Characterisation of a Population of EGFP-Expressing Cells from the Developing Pancreas of a Neurogenin3/EGFP Transgenic Mouse

Barrow, J., Bernardo, A. S., Blaylock, M. G., Duncan, L., MacKenzie, A., McCreath, K., Kind, A. J., Schnieke, A. E., Colman, A., Hart, A. W. & Docherty, K., 2005.

Research output: Contribution to conferencePoster

Purification and characterisation of a population of EGFP- expressing cells from the developing pancreas of a neurogenin3/EGFP transgenic mouse.

Barrow, J., Bernardo, A., Blaylock, M., Duncan, L., MacKenzie, A., McCreath, K., Kind, A. J., Schneike, A., Colman, A., Hart, A. W. & Docherty, K., 2005, In : Organogenesis. 2, p. 22-27 5 p.

Research output: Contribution to journalArticle

2004

Is there a functional link between gene interdigitation and multi-species conservation of synteny blocks?

MacKenzie, A., Miller, K. A. & Collinson, J. M., Nov 2004, In : BioEssays. 26, 11, p. 1217-1224 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Post-genomic approaches to exploring neuropeptide gene mis-expression in disease

MacKenzie, A. & Quinn, J., Feb 2004, In : Neuropeptides. 38, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2003

Tachykinin expression in cartilage and function in human articular chondrocyte mechanotransduction

Millward-Sadler, S. J., MacKenzie, A., Wright, M. O., Lee, H. S., Elliott, K., Gerrard, L., Fiskerstrand, C. E., Salter, D. M. & Quinn, J. P., Jan 2003, In : Arthritis & Rheumatism. 48, 1, p. 146-156 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2000
Open Access
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17 Citations (Scopus)
168 Downloads (Pure)
1999
310 Citations (Scopus)
1 Downloads (Pure)
1997

Two enhancer domains control early aspects of the complex expression pattern of Msx1

MacKenzie, A., Purdie, L., Davidson, D., Collinson, M. & Hill, R. E., Feb 1997, In : Mechanisms of Development. 62, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
1992

Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape.

MacKenzie, A., Ferguson, M. & Sharpe, P. T., 1992, In : Development. 115, 2, p. 403-420 18 p.

Research output: Contribution to journalArticle

255 Citations (Scopus)
1991

Hox-7 expression during murine craniofacial development

MacKenzie, A., Ferguson, M. & Sharpe, P. T., 1991, In : Development. 113, 2, p. 601-611 11 p., 1685989.

Research output: Contribution to journalArticle

132 Citations (Scopus)

The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro

MacKenzie, A., Leeming, G., Jowett, A. & Ferguson, M., 1991, In : Development. 111, 2, p. 269-285 17 p., 1680043.

Research output: Contribution to journalArticle

214 Citations (Scopus)