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Andrew McEwan


    • 348 Citations

    Research output per year

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    Personal profile

    Research Keywords:

    McEwan A. R.; Integrase; Phage; Streptomyces; Protein; DNA; Recombination; Integration; Macromolecular Complexes; Crystallography; EMSA; in vitro; in vivo;

    Research Interests:

    Post Doctoral Research in the Prof. M. C. M. Smith Group

    Institute of Medical Sciences, University of Aberdeen

    Investigation into the structure and function of phiC31 Streptomyces Phage Integrase (Int). Int is a member of the 'large serine recombinase' family. Int is required for integration of the phage genome into the host chromosome. This process of integration in highly site specific yet requires no additional co-factors or special conformations of DNA. The reverse reaction is equally specific in the presence of (the recently identified) Xis protein. The precise mechanism remains unknown. Int has been targeted as an application for use in gene therapies. Understanding of the mechanism and selectivity of Int is therefore essential if we are to adapt these proteins to specific sequences. Currently research has been directed towards a better understanding of the structure and function of these protein by studying the interactions between the protein and its substrates.  Recent work has been directed towards an analysis of mutations in both protein and substrate, through in vitro & in vivo recombination assays and electro-mobility shift assays and collaborations to determine other structural information such as high resolution structures.

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    Research Output

    • 348 Citations
    • 12 Article

    CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

    McEwan, A. R., Davidson, C., Hay, E., Turnbull, Y., Erickson, J. C., Marini, P., Wilson, D., McIntosh, A., Adams, M. J., Murgatroyd, C., Barrett, P., Delibegovic, M., Clarke, T-K. & MacKenzie, A., 13 Mar 2020, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  • Open Access
  • 4 Downloads (Pure)
    Open Access
  • 5 Citations (Scopus)
    5 Downloads (Pure)

    A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

    Booth, J., Alexandru-Crivac, C-N., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E. & Shalashilin, D. V., 18 May 2017, In : The Journal of Physical Chemistry Letters. 8, 10, p. 2310-2315 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)
    13 Downloads (Pure)

    Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

    Wichner, D., Idris, H., Houssen, W. E., McEwan, A. R., Bull, A. T., Asenjo, J. A., Goodfellow, M., Jaspars, M., Ebel, R. & Rateb, M. E., Apr 2017, In : The Journal of antibiotics. 70, p. 448-453 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • 15 Citations (Scopus)
    7 Downloads (Pure)