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Research Output 1998 2019

Article
8 Citations (Scopus)

A mathematical modelling framework for elucidating the role of feedback control in translation termination

de Silva, E., Krishnan, J., Betney, R. & Stansfield, I., 7 Jun 2010, In : Journal of Theoretical Biology. 264, 3, p. 808-821 14 p.

Research output: Contribution to journalArticle

stop codon
Mathematical Modeling
Termination
Feedback Control
translation (genetics)
8 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Chemical Kinetics
Reaction kinetics
Yeast
Open Reading Frames
Modeling and Simulation
15 Citations (Scopus)

Autoregulatory systems controlling translation factor expression: Thermostat-like control of translational accuracy

Betney, R., de Silva, E., Krishnan, J. & Stansfield, I., 25 Feb 2010, In : RNA . 16, 4, p. 655-663 9 p.

Research output: Contribution to journalArticle

Eukaryota
Peptide Initiation Factors
Ribosomes
Peptide Termination Factors
Codon
24 Citations (Scopus)

A yeast tRNA mutant that causes pseudohyphal growth exhibits reduced rates of CAG codon translation

Kemp, A., Betney, R., Ciandrini, L., Schwenger, A. C., Romano, M. C. & Stansfield, I., Jan 2013, In : Molecular Microbiology. 87, 2, p. 284–300 27 p.

Research output: Contribution to journalArticle

Transfer RNA
Codon
Open Reading Frames
Anticodon
Yeasts
12 Citations (Scopus)

Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA

Gorgoni, B., Marshall, E., McFarland, M. R., Romano, M. C. & Stansfield, I., Feb 2014, In : Biochemical Society Transactions. 42, 1, p. 160-165 6 p.

Research output: Contribution to journalArticle

Transfer RNA
Ribosomes
Elongation
Fluxes
Gene expression
8 Citations (Scopus)
5 Downloads (Pure)

Control of gag-pol gene expression in the Candida albicans retrotransposon Tca2

Forbes, E. M., Nieduszynska, S. R., Brunton, F. K., Gibson, J., Glover, L. A. & Stansfield, I., 25 Oct 2007, In : BMC Molecular Biology. 8, 14 p., 94.

Research output: Contribution to journalArticle

Open Access
File

Definition Of The Minimal Contents For The Molecular Simulation Of The Yeast Cytoplasm

Kompella, V. P. S., Stansfield, I., Romano, M. C. & Mancera, R. L., Oct 2019, In : Frontiers in Molecular Biosciences. 6, 9 p., 97.

Research output: Contribution to journalArticle

Open Access
File
Yeast
Proteins
Chemical analysis
Cell growth
Biomolecules
1 Downloads (Pure)

Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

Gorgoni, B., Zhao, Y-B., Krishnan, J. & Stansfield, I., Aug 2019, In : Cells. 8, 8, 25 p., 800.

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Terminator Codon
Eukaryota
Ribosomes
Messenger RNA
96 Citations (Scopus)

Endless possibilities: translation termination and stop codon recognition

Bertram, G., Innes, S., Minella, O., Richardson, J. & Stansfield, I., Feb 2001, In : Microbiology . 147, Pt 2, p. 255-269 15 p.

Research output: Contribution to journalArticle

592 Citations (Scopus)

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., Rheinbay, E., Grabherr, M., Forche, A., Reedy, J. L., Agrafioti, I., Arnaud, M. B., Bates, S., Brown, A. J. P., Brunke, S., Costanzo, M. C., Fitzpatrick, D. A., de Groot, P. W. J., Harris, D., Hoyer, L. L. & 31 others, Hube, B., Klis, F. M., Kodira, C., Lennard, N., Logue, M. E., Martin, R., Neiman, A. M., Nikolaou, E., Quail, M. A., Quinn, J., Santos, M. C., Schmitzberger, F. F., Sherlock, G., Shah, P., Silverstein, K. A. T., Skrzypek, M. S., Soll, D., Staggs, R., Stansfield, I., Stumpf, M. P. H., Sudbery, P. E., Srikantha, T., Zeng, Q., Berman, J., Berriman, M., Heitman, J., Gow, N. A. R., Lorenz, M. C., Birren, B. W., Kellis, M. & Cuomo, C. A., 4 Jun 2009, In : Nature. 459, 7247, p. 657-662 6 p.

Research output: Contribution to journalArticle

Candida
Reproduction
Virulence
Genome
Genes
43 Citations (Scopus)

Genome-wide prediction of stop codon readthrough during translation in the yeast Saccharomyces cerevisiae

Williams, I. A., Richardson, J. P., Starkey, A. & Stansfield, I., Dec 2004, In : Nucleic Acids Research. 32, 22, p. 6605-6616 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
8 Downloads (Pure)

Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation

Gorgoni, B., Ciandrini, L., McFarland, M. R., Romano, M. C. & Stansfield, I., 2 Nov 2016, In : Nucleic Acids Research. 44, 19, p. 9231-9244 14 p.

Research output: Contribution to journalArticle

Open Access
File
Transfer RNA
Genome
Messenger RNA
Ribosomes
Codon
55 Citations (Scopus)

Missense translation errors in Saccharomyces cerevisiae

Stansfield, I., Jones, K. M., Herbert, P., Lewendon, A., Shaw, W. V. & Tuite, M. F., 11 Sep 1998, In : Journal of Molecular Biology. 282, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

Codon
Saccharomyces cerevisiae
Histidine
Paromomycin
Anticodon
7 Citations (Scopus)
5 Downloads (Pure)

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile

Bonnin, P., Kern, N., Young, N. T., Stansfield, I. & Romano, M. C., May 2017, In : PLoS Computational Biology . 13, 5, e1005555.

Research output: Contribution to journalArticle

Open Access
File
polyribosomes
Polyribosomes
ribosomes
Ribosomes
Messenger RNA
119 Citations (Scopus)
5 Downloads (Pure)

Phylogenetic diversity of stress signalling pathways in fungi

Nikolaou, E., Agrafioti, I., Stumpf, M., Quinn, J., Stansfield, I. & Brown, A. JP., 21 Feb 2009, In : BMC Evolutionary Biology. 9, p. 44 1 p.

Research output: Contribution to journalArticle

Open Access
File
cell walls
fungus
phylogenetics
fungi
niches
26 Citations (Scopus)

Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance

Kinghorn, S. M., O'Byrne, C. P., Booth, I. R. & Stansfield, I., Nov 2002, In : Microbiology . 148, 11, p. 3511-3520 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Queueing phase transition: Theory of Translation

Romano, M. C., Thiel, M., Stansfield, I. & Grebogi, C., 15 May 2009, In : Physical Review Letters. 102, 19, 4 p., 198104.

Research output: Contribution to journalArticle

proteins
configurations
3 Citations (Scopus)

Regulation of release factor expression using a translational negative feedback loop: a systems analysis

Betney, R., de Silva, E., Mertens, C., Knox, Y., Krishnan, J. & Stansfield, I., Dec 2012, In : RNA . 18, 12, p. 2320-2334 15 p.

Research output: Contribution to journalArticle

Systems Analysis
Terminator Codon
Nonsense Codon
Transfer RNA
Yeasts
13 Citations (Scopus)
4 Downloads (Pure)

Ribosome recycling induces optimal translation rate at low ribosomal availability

Marshall, E., Stansfield, I. & Romano, M. C., 6 Sep 2014, In : Journal of the Royal Society Interface. 11, 98, 9 p., 20140589 .

Research output: Contribution to journalArticle

Open Access
File
Ribosomes
Recycling
Availability
Messenger RNA
Proteins
59 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Gene Ontology
polyribosomes
Polyribosomes
ribosomes
Ribosomes
50 Citations (Scopus)
3 Downloads (Pure)
Open Access
File
Asymmetric Exclusion Process
exclusion
Asymmetric Simple Exclusion Process
Messenger RNA
ribosomes
Microarray Analysis
Microarrays
Genomics
Students
Research
20 Citations (Scopus)
142 Citations (Scopus)

Terminating eukaryote translation: Domain 1 of release factor eRF1 functions in stop codon recognition

Bertram, G., Bell, H., Ritchie, D. W., Fullerton, G. & Stansfield, I., Sep 2000, In : RNA . 6, 9, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae

Eurwilaichitr, L., Graves, F. M., Stansfield, I. & Tuite, M. F., May 1999, In : Molecular Microbiology. 32, 3, p. 485-96 12 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Ribosomes
Amino Acids
Yeasts
Terminator Codon
9 Citations (Scopus)

The evolution of spliced leader trans-splicing in nematodes

Pettitt, J., Harrison, N., Stansfield, I., Connolly, B. & Müller, B., Aug 2010, In : Biochemical Society Transactions. 38, 4, p. 1125-1130 6 p.

Research output: Contribution to journalArticle

Spliced Leader RNA
Trans-Splicing
Genes
Ascaris
Caenorhabditis elegans

The worm profits from undercharging

Stansfield, I. & Proud, C. G., 8 Apr 2009, In : Cell Metabolism. 9, 4, p. 309-310 2 p.

Research output: Contribution to journalArticle

Amino Acid-Specific Transfer RNA
Mutation
Proteins
Cell Survival
Enzymes
23 Citations (Scopus)
6 Downloads (Pure)

Translational recoding as a feedback controller: systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift

Rato Da Silva, C. S., Amirova, S. R., Bates, D. G., Stansfield, I. & Wallace, H. M., 7 Feb 2011, In : Nucleic Acids Research. 39, 11, p. 4587-4597 11 p.

Research output: Contribution to journalArticle

Open Access
File
Ribosomal Frameshifting
Polyamines
Putrescine
Spermidine
Spermine
61 Citations (Scopus)

tRNA properties help shape codon pair preferences in open reading frames

Buchan, J. R., Aucott, L. S. & Stansfield, I., 2006, In : Nucleic Acids Research. 34, 3, p. 1015-1027 13 p.

Research output: Contribution to journalArticle

Transfer RNA
Codon
Open Reading Frames
Nucleotides
Eukaryota
Chapter

Yeast gene analysis: the remaining challenges

Stark, M. J. R. & Stansfield, I., 17 Apr 2007, Methods in Microbiology: Yeast Gene Analysis. Stansfield, I. & Stark, M. (eds.). 2 ed. Vol. 36. p. 667-683 17 p. (Methods in Microbiology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Literature review
81 Citations (Scopus)

Halting a cellular production line: Responses to ribosomal pausing during translation

Buchan, J. R. & Stansfield, I., Sep 2007, In : Molecular Biology of the Cell. 99, 9, p. 475-487 13 p.

Research output: Contribution to journalLiterature review

Poster

Dominant-negative release factors and their effect on termination and translational recoding events

McFarland, M. R., Romano, M. C. & Stansfield, I., 25 Jan 2014, (Unpublished).

Research output: Contribution to conferencePoster

Dominant-negative release factors and their effect on termination and translational recoding events

McFarland, M. R., Romano, M. C. & Stansfield, I., 4 Jul 2013, (Unpublished).

Research output: Contribution to conferencePoster

Working paper
File
RNA, Transfer, Gln
Amino Acyl-tRNA Synthetases
Starvation
Transfer RNA
Maintenance