• 1834 Citations
19952020

Research output per year

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Research Output

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Firulli, B. A., Krawchuk, D., Centonze, V. E., Vargesson, N., Virshup, D. M., Conway, S. J., Cserjesi, P., Laufer, E. & Firulli, A. B., Apr 2005, In : Nature Genetics. 37, 4, p. 373-381 8 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In : Scientific Reports. 8, 10 p., 15674.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
8 Downloads (Pure)

A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In : Reproductive Toxicology. 70, p. 126-132 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
5 Downloads (Pure)

Arterial dysgenesis and limb defects: Clinical and experimental examples

Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 21-29 9 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
7 Downloads (Pure)

Cell fate in the chick limb bud and relationship to gene expression

Vargesson, N., Clarke, J. D., Vincent, K., Coles, C., Wolpert, L. & Tickle, C., 15 May 1997, In : Development. 124, 10, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Characterisation of hoxa gene expression in the chick limb bud in response to FGF

Vargesson, N., Kostakopoulou, K., Drossopoulou, G., Papageorgiou, S. & Tickle, C., 1 Jan 2001, In : Developmental Dynamics. 220, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., Aug 2017, In : Stem Cells. 35, 8, p. 1958-1972 15 p.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
10 Downloads (Pure)

Congenital Embryonic Arterial and Skeletal Dysgeneses

Hootnick, D. R., DeSesso, J. & Vargesson, N., Jul 2016, In : RadioGraphics. 36, 4, p. 1257-1257 1 p.

Research output: Contribution to journalLetter

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In : Journal of Anatomy. 232, 4, p. 568-574 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-Mcnaughton, L., Morrison, A. & Lewis, J., 1 Mar 2005, In : Development. 132, p. 1093-1104 11 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
6 Downloads (Pure)

Developmental Angiogenesis

Vargesson, N., Jun 2017, In : Reproductive Toxicology. 70, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Embryos, teratogens and birth defects

Vargesson, N., Sep 2017, In : Journal of Anatomy. 231, 3, p. 449 1 p.

Research output: Contribution to journalAbstract

91 Citations (Scopus)

Expression analysis of limb element markers during mouse embryonic development

Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In : Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb

Vargesson, N., Patel, K., Lewis, J. & Tickle, C., 1 Oct 1998, In : Mechanisms of Development. 77, 2, p. 197-200 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Expression patterns of Slit and Robo family members during vertebrate limb development

Vargesson, N., Luria, V., Messina, I., Erskine, L. & Laufer, E., Aug 2001, In : Mechanisms of Development. 106, 1-2, p. 175-180 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In : Oncotarget. 7, 22, p. 33237-33245 9 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
4 Downloads (Pure)

Lens-regulated retinoic acid signalling controls expansion of the developing eye

Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In : Development. 145, 19, dev167171.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
2 Downloads (Pure)

Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., Dec 2018, In : Stem Cell Research. 33, 12, p. 185-198 14 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps

Kostakopoulou, K., Vargesson, N., Clarke, J. D., Brickell, P. M. & Tickle, C., 1 Oct 1997, In : International Journal of Developmental Biology. 41, 5, p. 747-750 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Molecular analysis of regulative events in the developing chick limb

Mahony, C. & Vargesson, N., 1 Jul 2013, In : Journal of Anatomy. 223, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Negative Smad expression and regulation in the developing chick limb

Vargesson, N. & Laufer, E., 8 Apr 2009, In : PloS ONE. 4, 4, 8 p., e5173.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
5 Downloads (Pure)

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In : PNAS. 110, 31, p. 12703-12708 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Positional Information – a concept underpinning our understanding of developmental biology

Vargesson, N., 1 Mar 2020, In : Developmental Dynamics. 249, 3, p. 298-312 15 p.

Research output: Contribution to journalArticle

Open Access

Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In : Vision Research. 127, p. 104-114 11 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
4 Downloads (Pure)

Regarding a limb with PFFD, fibular dimelia and mirror foot deformity

Hootnick, D. R., Vargesson, N. & Birch, J., 1 Nov 2017, In : Journal of Pediatric Orthopaedics B. 26, 6, p. 589-589 1 p.

Research output: Contribution to journalLetter

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J. D., Niswander, L., McMahon, A. & Tickle, C., 1 Nov 1997, In : Development. 124, 21, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

273 Citations (Scopus)

Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In : PNAS. 110, 50, E4820.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of cereblon in angiogenesis and in mediating the anti-angiogenic activity of immunomodulatory drugs

Beedie, S-L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., 27 Apr 2020, (Accepted/In press) In : The FASEB Journal.

Research output: Contribution to journalArticle

Roles of Roundabout and Slits in developing limb joint formation

Diamond, A., Erskine, L. & Vargesson, N., Apr 2015, In : International journal of experimental pathology. 96, 2, p. A8-A8 1 p.

Research output: Contribution to journalAbstract

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In : Scientific Reports. 6, p. 1-10 10 p., 30038.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
5 Downloads (Pure)
Open Access
26 Citations (Scopus)

SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma

Gregory-Evans, C. Y., Moosajee, M., Hodges, M. D., Mackay, D. S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pinto, L., Wackens, G. & Gregory-Evans, K., 15 Oct 2007, In : Human Molecular Genetics. 16, 20, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth

Al-Jamal, K. T., Al-Jamal, W. T., Akerman, S., Podesta, J. E., Yilmazer, A., Turton, J. A., Bianco, A., Vargesson, N., Kanthou, C., Florence, A. T., Tozer, G. M. & Kostarelos, K., 2 Mar 2010, In : PNAS. 107, 9, p. 3966-3971 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Teratogenesis

Vargesson, N. & Fraga, L., 15 Dec 2017, In : eLS. p. 1-7 7 p., a0026056.

Research output: Contribution to journalArticle

TGFbeta superfamily signalling in the developing limb vasculature

Vargesson, N., 1 Nov 2002, In : Journal of Anatomy. 201, 5, p. 422-423 2 p.

Research output: Contribution to journalArticle

TGFβ superfamily signalling in the developing limb vasculature

Vargesson, N., Nov 2002, In : Journal of Anatomy. 201, 5, p. 422-423 2 p.

Research output: Contribution to journalAbstract

Thalidomide

Vargesson, N., 21 Apr 2017, Reproductive and Developmental Toxicology . Gupta, R. C. (ed.). 2nd ed. Academic Press, p. 467-479 13 p. Chapter 26

Research output: Chapter in Book/Report/Conference proceedingChapter

Thalidomide

Vargesson, N., Mar 2011, Reproductive and Developmental Toxicology. Gupta, R. (ed.). Elsevier Science , p. 395-403 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thalidomide and birth defects

Fraga, L., Diamond, A. & Vargesson, N., 2016, In : eLS. January 2016, p. 1-11 11 p., a0026052.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Thalidomide embryopathy: an enigmatic challenge

Vargesson, N., 2013, In : ISRN Developmental Biology. 2013, 18 p., 241016.

Research output: Contribution to journalLiterature review

Open Access
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9 Downloads (Pure)

Thalidomide-induced limb defects: resolving a 50-year-old puzzle

Vargesson, N., Dec 2009, In : BioEssays. 31, 12, p. 1327-1336 10 p.

Research output: Contribution to journalLiterature review

88 Citations (Scopus)

Thalidomide-induced Teratogenesis: History and Mechanisms

Vargesson, N., Jun 2015, In : Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

Research output: Contribution to journalArticle

Open Access
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219 Citations (Scopus)
14 Downloads (Pure)

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D. & Vargesson, N., 26 May 2009, In : PNAS. 106, 21, p. 8573-8578 6 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)

The chick limb: embryology, genetics and teratology

Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In : International Journal of Developmental Biology. 62, p. 85-95 11 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
5 Downloads (Pure)

The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In : Development. 145, 3, dev160093.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
13 Downloads (Pure)

The developmental basis of clubfoot

Lindstrom, N., McIntosh, R., Sapsford, H., Vargesson, N., Miedzybrodzka, Z. & Collinson, M., Aug 2009, In : Mechanisms of Development. 126, Supplement, p. S126 1 p., 06-P019.

Research output: Contribution to journalAbstract