• 1809 Citations
19952020

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Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

Firulli, B. A., Krawchuk, D., Centonze, V. E., Vargesson, N., Virshup, D. M., Conway, S. J., Cserjesi, P., Laufer, E. & Firulli, A. B., Apr 2005, In : Nature Genetics. 37, 4, p. 373-381 8 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In : Scientific Reports. 8, 10 p., 15674.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
6 Downloads (Pure)

A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In : Reproductive Toxicology. 70, p. 126-132 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
5 Downloads (Pure)

Arterial dysgenesis and limb defects: Clinical and experimental examples

Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 21-29 9 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
7 Downloads (Pure)

Cell fate in the chick limb bud and relationship to gene expression

Vargesson, N., Clarke, J. D., Vincent, K., Coles, C., Wolpert, L. & Tickle, C., 15 May 1997, In : Development. 124, 10, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Characterisation of hoxa gene expression in the chick limb bud in response to FGF

Vargesson, N., Kostakopoulou, K., Drossopoulou, G., Papageorgiou, S. & Tickle, C., 1 Jan 2001, In : Developmental Dynamics. 220, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., Aug 2017, In : Stem Cells. 35, 8, p. 1958-1972 15 p.

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24 Citations (Scopus)
10 Downloads (Pure)

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In : Journal of Anatomy. 232, 4, p. 568-574 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-Mcnaughton, L., Morrison, A. & Lewis, J., 1 Mar 2005, In : Development. 132, p. 1093-1104 11 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
6 Downloads (Pure)
90 Citations (Scopus)

Expression analysis of limb element markers during mouse embryonic development

Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In : Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

Open Access
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Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb

Vargesson, N., Patel, K., Lewis, J. & Tickle, C., 1 Oct 1998, In : Mechanisms of Development. 77, 2, p. 197-200 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Expression patterns of Slit and Robo family members during vertebrate limb development

Vargesson, N., Luria, V., Messina, I., Erskine, L. & Laufer, E., Aug 2001, In : Mechanisms of Development. 106, 1-2, p. 175-180 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In : Oncotarget. 7, 22, p. 33237-33245 9 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
4 Downloads (Pure)

Lens-regulated retinoic acid signalling controls expansion of the developing eye

Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In : Development. 145, 19, dev167171.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
2 Downloads (Pure)

Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., Dec 2018, In : Stem Cell Research. 33, 12, p. 185-198 14 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps

Kostakopoulou, K., Vargesson, N., Clarke, J. D., Brickell, P. M. & Tickle, C., 1 Oct 1997, In : International Journal of Developmental Biology. 41, 5, p. 747-750 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Molecular analysis of regulative events in the developing chick limb

Mahony, C. & Vargesson, N., 1 Jul 2013, In : Journal of Anatomy. 223, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Negative Smad expression and regulation in the developing chick limb

Vargesson, N. & Laufer, E., 8 Apr 2009, In : PloS ONE. 4, 4, 8 p., e5173.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
5 Downloads (Pure)

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In : PNAS. 110, 31, p. 12703-12708 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Positional Information – a concept underpinning our understanding of developmental biology

Vargesson, N., 1 Mar 2020, In : Developmental Dynamics. 249, 3, p. 298-312 15 p.

Research output: Contribution to journalArticle

Open Access

Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In : Vision Research. 127, p. 104-114 11 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
4 Downloads (Pure)

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J. D., Niswander, L., McMahon, A. & Tickle, C., 1 Nov 1997, In : Development. 124, 21, p. 4393-4404 12 p.

Research output: Contribution to journalArticle

271 Citations (Scopus)

Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In : PNAS. 110, 50, E4820.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of cereblon in angiogenesis and in mediating the anti-angiogenic activity of immunomodulatory drugs

Beedie, S-L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., 27 Apr 2020, (Accepted/In press) In : The FASEB Journal.

Research output: Contribution to journalArticle

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In : Scientific Reports. 6, p. 1-10 10 p., 30038.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
5 Downloads (Pure)
Open Access
26 Citations (Scopus)

SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma

Gregory-Evans, C. Y., Moosajee, M., Hodges, M. D., Mackay, D. S., Game, L., Vargesson, N., Bloch-Zupan, A., Rüschendorf, F., Santos-Pinto, L., Wackens, G. & Gregory-Evans, K., 15 Oct 2007, In : Human Molecular Genetics. 16, 20, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth

Al-Jamal, K. T., Al-Jamal, W. T., Akerman, S., Podesta, J. E., Yilmazer, A., Turton, J. A., Bianco, A., Vargesson, N., Kanthou, C., Florence, A. T., Tozer, G. M. & Kostarelos, K., 2 Mar 2010, In : PNAS. 107, 9, p. 3966-3971 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Teratogenesis

Vargesson, N. & Fraga, L., 15 Dec 2017, In : eLS. p. 1-7 7 p., a0026056.

Research output: Contribution to journalArticle

TGFbeta superfamily signalling in the developing limb vasculature

Vargesson, N., 1 Nov 2002, In : Journal of Anatomy. 201, 5, p. 422-423 2 p.

Research output: Contribution to journalArticle

Thalidomide and birth defects

Fraga, L., Diamond, A. & Vargesson, N., 2016, In : eLS. January 2016, p. 1-11 11 p., a0026052.

Research output: Contribution to journalArticle

Open Access
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Thalidomide-induced Teratogenesis: History and Mechanisms

Vargesson, N., Jun 2015, In : Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

Research output: Contribution to journalArticle

Open Access
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209 Citations (Scopus)
14 Downloads (Pure)

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

Therapontos, C., Erskine, L., Gardner, E. R., Figg, W. D. & Vargesson, N., 26 May 2009, In : PNAS. 106, 21, p. 8573-8578 6 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)

The chick limb: embryology, genetics and teratology

Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In : International Journal of Developmental Biology. 62, p. 85-95 11 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
5 Downloads (Pure)

The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In : Development. 145, 3, dev160093.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
11 Downloads (Pure)

The ectodermal control in chick limb development: Wnt-7a, Shh, Bmp-2 and Bmp-4 expression and the effect of FGF-4 on gene expression

Akita, K., Francis-West, P. & Vargesson, N., 1 Dec 1996, In : Mechanisms of Development. 60, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

'The Legacy of Thalidomide' - a multidisciplinary Meeting held at the University of York, UK on September 30, 2016

Newbronner, E., Vargesson, N. & Atkin, K., 1 Mar 2017, In : Birth Defects Research. 109, 4, p. 296–299 4 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
4 Downloads (Pure)

The NOTCH Pathway Contributes To Cell Fate Decision In Myelopoiesis

Bugeon, L., Taylor, H., Progatzky, F., Lin, M., Ellis, C., Welsh, N., Smith, E., Vargesson, N., Gray, C., Renshaw, S., Chico, T., Zon, L., Lamb, J. & Dallman, MJ., Dec 2011, In : Haematologica. 96, 12, p. 1753-1760 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The Primodos components Noretheristerone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos

Brown, S., Rosa Fraga, L., Cameron, G., Erskine, L. & Vargesson, N., 13 Feb 2018, In : Scientific Reports. 8, 2917.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
7 Downloads (Pure)

The syndrome of proximal femur, fibula, and midline metatarsal long bone deficiencies

Hootnick, D. R. & Vargesson, N., 1 Sep 2018, In : Birth Defects Research. 110, 15, p. 1188-1193 6 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
1 Downloads (Pure)

The teratogenic effects of thalidomide on limbs

Vargesson, N., 1 Jan 2019, In : Journal of hand surgery-European volume. 44, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
10 Downloads (Pure)

Tissue specific characterisation of Lim-kinase 1 expression during mouse embryogenesis

Lindström, N. O., Neves, C., McIntosh, R., Miedzybrodzka, Z. H., Vargesson, N. & Collinson, J. M., Mar 2011, In : Gene Expression Patterns. 11, 3-4, p. 221-232 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Vascular anomalies of the upper limb

Mende, K., Vargesson, N. & Sivakumar, B., 1 Mar 2019, In : Journal of hand surgery-European volume. 44, 3, p. 233-241 9 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
1 Downloads (Pure)

VEGF-A and Neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

Erskine, L., Francois, U., Denti, L., Joyce, A., Tillo, M., Bruce, F., Vargesson, N. & Ruhrberg, C., Jul 2017, In : Development. 144, 13, p. 2504-2516 13 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
7 Downloads (Pure)

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Beedie, S., Diamond, A. J., Rosa Fraga, L., Figg, W. D. & Vargesson, N., 1 Jun 2017, In : Reproductive Toxicology. 70, p. 49-59 10 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
10 Downloads (Pure)

VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle

Figeac, N., Mohamed, A. D., Sun, C., Schönfelder, M., Matallanas, D., Garcia-Munoz, A., Missiaglia, E., Collie-Duguid, E., De Mello, V., Pobbati, A. V., Pruller, J., Jaka, O., Harridge, S. D. R., Hong, W., Shipley, J., Vargesson, N., Zammit, P. S. & Wackerhage, H., 5 Jul 2019, In : Journal of Cell Science. 132, jcs225946 .

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
2 Downloads (Pure)

Zebrafish notch signalling pathway mutants exhibit trunk vessel patterning anomalies that are secondary to somite misregulation

Therapontos, C. & Vargesson, N., Oct 2010, In : Developmental Dynamics. 239, 10, p. 2761-2768 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)