• 2279 Citations
19992020
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Research Output 1999 2020

2020
Aspirin
Brain
Aging of materials
Cognition
Processing
2019
1 Downloads (Pure)

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

Research output: Contribution to journalArticle

Open Access
File
Atrophy
Alzheimer Disease
Brain
Therapeutics
Pharmaceutical Preparations
1 Citation (Scopus)
8 Downloads (Pure)
Open Access
File
Aging of materials
Brain
Neurodegenerative diseases
Complex networks
Magnetic resonance
Open Access
Entropy
Magnetic Resonance Imaging
Brain
Somatosensory Cortex
Head
2018
4 Citations (Scopus)
10 Downloads (Pure)
Open Access
File
Dementia
Biomarkers
Magnetic Resonance Imaging
Pathology
Blood Pressure
2 Citations (Scopus)
7 Downloads (Pure)

Intellectual engagement and cognitive ability in later life (the "use it or lose it" conjecture): Longitudinal, prospective study

Staff, R. T., Hogan, M. J., Williams, D. S. & Whalley, L. J., 10 Dec 2018, In : BMJ (Online). 363, k4925.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Longitudinal Studies
Prospective Studies
Volunteers
Scotland

Klotho gene polymorphism, brain structure and cognition in early-life development

de Vries, C. F., Staff, R., Noble, K. G., Muetzel, R. L., Vernooij, M. W., White, T., Waiter, G. D. & Murray, A. D., 5 Nov 2018, In : Brain Imaging and Behavior. 13 p.

Research output: Contribution to journalArticle

Open Access
Cognition
Brain
Heterozygote
Genes
Episodic Memory
17 Citations (Scopus)
5 Downloads (Pure)

Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review

Chapko, D., McCormack, R., Black, C., Staff, R. & Murray, A., 2018, In : Aging & Mental Health. 22, 8, p. 915-926 12 p.

Research output: Contribution to journalArticle

Open Access
File
Cognitive Reserve
Dementia
Occupations
Cognition
Education
2 Citations (Scopus)

The influence of childhood intelligence, social class, education and social mobility on memory and memory decline in late life

Staff, R. T., Hogan, M. J. & Whalley, L. J., 1 Nov 2018, In : Age and Ageing. 47, 6, p. 847-852 6 p.

Research output: Contribution to journalArticle

Social Mobility
Intelligence
Social Class
Verbal Learning
Education
2017
17 Citations (Scopus)
13 Downloads (Pure)

A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)

Job, D. E., Dickie, D. A., Rodriguez, D., Robson, A., Pernet, C., Bastin, M. E., Boardman, J. P., Murray, A. D., Ahearn, T., Waiter, G. D., Staff, R. T., Deary, I. J., Shenkin, S. D. & Wardlaw, J. M., 1 Jan 2017, In : Neuroimage. 144, Part B, p. 299–304 6 p.

Research output: Contribution to journalArticle

Open Access
File
Neuroimaging
Brain
Healthy Volunteers
Diffusion Tensor Imaging
Databases
6 Citations (Scopus)
7 Downloads (Pure)
Open Access
File
Social Mobility
Intelligence
Personality
Aptitude
Parturition
5 Citations (Scopus)
11 Downloads (Pure)

Klotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936

de Vries, C. F., Staff, R. T., Harris, S. E., Chapko, D., Williams, D. S., Reichert, P., Ahearn, T., McNeil, C. J., Whalley, L. J. & Murray, A. D., Jul 2017, In : Neurobiology of Aging. 55, p. 91-98 8 p.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Heterozygote
Atrophy
Parturition
Cognition
23 Citations (Scopus)
15 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

Research output: Contribution to journalArticle

Open Access
File
Phase III Clinical Trials
Alzheimer Disease
Cohort Studies
Atrophy
Activities of Daily Living
2016
8 Citations (Scopus)
9 Downloads (Pure)
Open Access
File
Cognition
cognitive ability
cognition
brain
Aptitude
14 Citations (Scopus)
9 Downloads (Pure)

Cerebral correlates of cognitive reserve

Whalley, L. J., Staff, R. T., Fox, H. C. & Murray, A. D., 30 Jan 2016, In : Psychiatry Research. 247, p. 65-70 6 p.

Research output: Contribution to journalArticle

Open Access
File
Cognitive Reserve
Dementia
Cerebrovascular Disorders
Brain
Pathology
108 Citations (Scopus)
4 Downloads (Pure)

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., Dec 2016, In : The Lancet. 388, 10062, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Safety
Activities of Daily Living
Therapeutics
Amyloid
7 Citations (Scopus)
Open Access
Intelligence
Parturition
Occupations
Aptitude
Structural Models
2015

A longitudinal study of cognitive and hippocampal ageing in late life

Sandu-Giuraniuc, A-L., Rana, A., Robertson, K. L., Ahearn, T., McNeil, C. J., Staff, R. & Murray, A. D., 12 Apr 2015.

Research output: Contribution to conferenceAbstract

15 Citations (Scopus)
16 Downloads (Pure)

Fuzzy approximate entropy analysis of resting state fMRI signal complexity across the adult life span

Sokunbi, M. O., Cameron, G. G., Ahearn, T. S., Murray, A. D. & Staff, R. T., Nov 2015, In : Medical Engineering & Physics. 37, 11, p. 1082-1090 9 p.

Research output: Contribution to journalArticle

File
Entropy
Magnetic Resonance Imaging
Parietal Lobe
Systems Analysis
Cerebellum

Phenothiazine compounds for treating mild cognitive impairment

Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D. & Staff, R. T., 15 Dec 2015, Patent No. US9211294, 17 Jun 2008, Priority date 19 Jun 2007, Priority No. 60/945006

Research output: Patent

Cognitive Dysfunction
phenothiazine
124 Citations (Scopus)
4 Downloads (Pure)

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A. & Harrington, C. R., 22 Jan 2015, In : Journal of Alzheimer's Disease. 44, 2, p. 705-720 16 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Cerebrovascular Circulation
Regional Blood Flow
Therapeutics
Pathology
2014

A longitudinal study of human brain complexity and cognitive decline in ageing

Sandu-Giuraniuc, A-L., Staff, R., McNeil, C. J., Mustafa, N., Ahearn, T., Whalley, L. & Murray, A. D., 8 Jun 2014.

Research output: Contribution to conferenceAbstract

Open Access
18 Citations (Scopus)
5 Downloads (Pure)

Early life socioeconomic circumstances and late life brain hyperintensities: a population based cohort study

Murray, A. D., McNeil, C. J., Salarirad, S., Whalley, L. J. & Staff, R. T., 18 Feb 2014, In : PloS ONE. 9, 2, 7 p., e88969.

Research output: Contribution to journalArticle

Open Access
File
cohort studies
socioeconomics
Brain
Cohort Studies
brain
13 Citations (Scopus)

Homocysteine, antioxidant micronutrients and late onset dementia

Whalley, L. J., Duthie, S. J., Collins, A. R., Starr, J. M., Deary, I. J., Lemmon, H., Duthie, A. C., Murray, A. D. & Staff, R. T., Feb 2014, In : European Journal of Nutrition. 53, 1, p. 277-285 9 p.

Research output: Contribution to journalArticle

Micronutrients
Homocysteine
Dementia
Antioxidants
Folic Acid
20 Citations (Scopus)
6 Downloads (Pure)

Improving the cost-effectiveness of photographic screening for diabetic macular oedema: a prospective, multi-centre, UK study

Prescott, G., Sharp, P., Goatman, K., Scotland, G., Fleming, A., Philip, S., Staff, R., Santiago, C., Borooah, S., Broadbent, D., Chong, V., Dodson, P., Harding, S., Leese, G., Megaw, R., Styles, C., Swa, K., Wharton, H. & Olson, J., Aug 2014, In : British Journal of Ophthalmology. 98, 8, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
6 Downloads (Pure)

Nonlinear complexity analysis of brain FMRI signals in schizophrenia

Sokunbi, M. O., Gradin, V. B., Waiter, G. D., Cameron, G. G., Ahearn, T. S., Murray, A. D., Steele, D. J. & Staff, R. T., 13 May 2014, In : PloS ONE. 9, 5, 10 p., e95146.

Research output: Contribution to journalArticle

Open Access
File
Systems Analysis
Brain
Schizophrenia
Entropy
entropy
14 Citations (Scopus)
7 Downloads (Pure)

Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort

Sandu-Giuraniuc, A-L., Staff, R. T., McNeil, C. J., Mustafa, N., Ahearn, T., Whalley, L. J. & Murray, A. D., 15 Oct 2014, In : Neuroimage. 100, p. 558-563 6 p.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Longitudinal Studies
Parturition
Brain
Fractals
2013
9 Citations (Scopus)

Depressive symptoms in late life and cerebrovascular disease: the importance of intelligence and lesion location

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Phillips, L. H., Starr, J., Deary, I. J. & Whalley, L. J., Jan 2013, In : Depression and Anxiety. 30, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

Cerebrovascular Disorders
Intelligence
Depression
Basal Ganglia
Anxiety
9 Citations (Scopus)

Genetic and environmental factors in late onset dementia: possible role for early parental death

Whalley, L. J., Staff, R. T., Murray, A. D., Deary, I. J. & Starr, J. M., Jan 2013, In : International Journal of Geriatric Psychiatry. 28, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Parental Death
Dementia
Genotype
Education
Nuclear Family
2012
25 Citations (Scopus)

Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementia

Whalley, L. J., Sharma, S., Fox, H. C., Murray, A. D., Staff, R. T., Duthie, A. C., Deary, I. J. & Starr, J. M., May 2012, In : Journal of Alzheimer's Disease. 30, 2, p. 253-261 9 p.

Research output: Contribution to journalArticle

Cholinergic Antagonists
Cognition
Dementia
Pharmaceutical Preparations
Social Class
20 Citations (Scopus)

Brain lesions, hypertension and cognitive aging in the 1921 and 1936 Aberdeen birth cohorts

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Starr, J. M., Deary, I. J. & Whalley, L. J., Apr 2012, In : Age. 34, 2, p. 451-459 9 p.

Research output: Contribution to journalArticle

Intelligence
Parturition
Hypertension
Brain
White Matter
24 Citations (Scopus)

Brain structural complexity and life course cognitive change

Mustafa, N., Ahearn, T. S., Waiter, G. D., Murray, A. D., Whalley, L. J. & Staff, R. T., 2 Jul 2012, In : Neuroimage. 61, 3, p. 694-701 8 p.

Research output: Contribution to journalArticle

Fractals
Brain
Intelligence
Crows
Aptitude
81 Citations (Scopus)
Social Class
Brain
Aptitude
Dementia
Education
7 Citations (Scopus)

Do brain image databanks support understanding of normal ageing brain structure? A systematic review

Dickie, D. A., Job, D. E., Poole, I., Ahearn, T. S., Staff, R. T., Murray, A. D. & Wardlaw, J. M., Jul 2012, In : European Radiology. 22, 7, p. 1385-1394 10 p.

Research output: Contribution to journalArticle

Databases
Brain
Magnetic Resonance Spectroscopy
Dementia
Selection Bias
2011
42 Citations (Scopus)

Cerebellar brain volume accounts for variance in cognitive performance in older adults

Hogan, M. J., Staff, R. T., Bunting, B. P., Murray, A. D., Ahearn, T. S., Deary, I. J. & Whalley, L. J., Apr 2011, In : Cortex. 47, 4, p. 441-450 10 p.

Research output: Contribution to journalArticle

Cerebellum
Frontal Lobe
Brain
Cognition
Neurological Models
8 Citations (Scopus)

Childhood intelligence and brain white matter hyperintensities predict fluid intelligence age 78-81 years: a 1921 Aberdeen birth cohort study

Salarirad, S., Staff, R. T., Fox, H. C., Deary, I. J., Whalley, L. & Murray, A. D., Sep 2011, In : Age and Ageing. 40, 5, p. 562-567 6 p.

Research output: Contribution to journalArticle

Intelligence
Aptitude
Cohort Studies
Parturition
Brain
34 Citations (Scopus)

How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability

Whalley, L. J., Murray, A. D., Staff, R. T., Starr, J. M., Deary, I. J., Fox, H. C., Lemmon, H., Duthie, S. J., Collins, A. R. & Crawford, J. R., Aug 2011, In : Maturitas. 69, 4, p. 365-372 8 p.

Research output: Contribution to journalArticle

Dementia
Parturition
Cohort Studies
Nutrigenomics
Bone
29 Citations (Scopus)

Inter-individual differences in fMRI entropy measurements in old age

Sokunbi, M. O., Staff, R. T., Waiter, G. D., Ahearn, T. S., Fox, H. C., Deary, I. J., Starr, J. M., Whalley, L. J. & Murray, A. D., Nov 2011, In : IEEE Transactions on Biomedical Engineering. 58, 11, p. 3206-3214 9 p.

Research output: Contribution to journalArticle

Entropy
Inspection
Magnetic Resonance Imaging
12 Citations (Scopus)

Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

Reilly, T. J., Staff, R. T., Ahearn, T. S., Bentham, P., Wischik, C. M. & Murray, A. D., 23 Sep 2011, In : Behavioural Brain Research. 222, 2, p. 375-379 5 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Regional Blood Flow
Prefrontal Cortex
Alzheimer Disease
Obsessive-Compulsive Disorder
71 Citations (Scopus)

The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Ahearn, T. S., Mustafa, N. & Whalley, L. J., Dec 2011, In : Brain. 134, 12, p. 3687-3696 10 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Cerebrovascular Disorders
Neuroimaging
Alzheimer Disease
Biomarkers
Cerebrovascular Circulation
Alzheimer Disease
Emotions
Aptitude
Frontal Lobe
2010
16 Citations (Scopus)

Brain volume and survival from age 78 to 85: the contribution of Alzheimer-type magnetic resonance imaging findings

Staff, R. T., Murray, A. D., Ahearn, T., Salarirad, S., Mowat, D., Starr, J. M., Deary, I. J., Lemmon, H. & Whalley, L. J., Apr 2010, In : Journal of the American Geriatrics Society. 58, 4, p. 688-695 8 p.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Brain
Dementia
Alzheimer Disease
Aptitude
57 Citations (Scopus)
Meta-Analysis
Lymph Nodes
Breast Neoplasms
ROC Curve
Area Under Curve
2009

Approximate entropy fMRI differences associated with cognitive decline

Roijals Miras, J., Staff, R., Waiter, G. D., Murray, A. D., Fox, H. C., Starr, J., Deary, I. J. & Whalley, L., Jul 2009, In : Neuroimage. 47, Supplement 1, p. S102 1 p.

Research output: Contribution to journalAbstract

13 Citations (Scopus)
Nortropanes
Parkinsonian Disorders
Single-Photon Emission-Computed Tomography
Automated Pattern Recognition
Automation