Tara Sutherland

Research output

Research output per year 2005 2005 2007 2009 2012 2014 2015 2017 2018 2019 2020 2021 2023 2023

• 29 Article
• 3 Preprint
• 2 Abstract
• 1 Letter
• 1 More
  • 1 Review article

Research output per year

Research output per year

Search results

• 2023

  The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration

  Ajendra, J., Papotto, P. H., Parkinson, J. E., Dodd, R. J., Bombeiro, A. L., Pearson, S., Chan, B. H. K., Ribot, J. C., McSorley, H. J., Sutherland, T. E. & Allen, J. E., 1 Dec 2023, In: Mucosal Immunology. 16, 6, p. 767-775 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-33 100%
  • Interleukin-17 77%
  • Neutrophils 57%
  • Epithelial Cells 52%
  • Lung 39%

• The extracellular matrix and the immune system: A mutually dependent relationship

  Sutherland, T., Allen, J. E. & Dyer, D. P., 17 Feb 2023, In: Science. 379, 6633, 10 p., eabp8964.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • extracellular matrix 100%
  • immune system 90%
  • immunology 39%
  • cells 30%
  • biologists 17%
  62 Citations (Scopus)

  5 Downloads (Pure)
• 2022

  Taming the neutrophil: Balance between anti‐parasite defence and pathogenesis

  Sutherland, T. E. & Steen, P. E. V. D., 1 Jun 2022, In: Parasite Immunology. 2 p., e12923.

  Research output: Contribution to journal › Article

  Open Access

  File

  • neutrophils 100%
  • pathogenesis 97%
  • Neutrophils 83%
  • parasites 48%
  • Parasitic Diseases 46%
  1 Downloads (Pure)
• 2021

  IL-13 is a driver of COVID-19 severity

  Donlan, A. N., Sutherland, T. E., Marie, C., Preissner, S., Bradley, B. T., Carpenter, R. M., Sturek, J. M., Ma, J. Z., Moreau, G. B., Donowitz, J. R., Buck, G. A., Serrano, M. G., Burgess, S. L., Abhyankar, M. M., Mura, C., Bourne, P. E., Preissner, R., Young, M. K., Lyons, G. R., Loomba, J. J., & 7 othersRatcliffe, S. J., Poulter, M. D., Mathers, A. J., Day, A. J., Mann, B. J., Allen, J. E. & Jr, W. A. P., 9 Aug 2021, In: JCI Insight. 6, 15, 17 p., 150107.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-13 100%
  • Hyaluronic Acid 66%
  • SARS Virus 23%
  • Hyaluronan Receptors 23%
  • Lung Diseases 21%
  93 Citations (Scopus)

  3 Downloads (Pure)

• Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity

  Sutherland, T. E., Shaw, T. N., Lennon, R., Herrick, S. E. & Rückerl, D., 27 Jul 2021, In: Frontiers in Immunology. 12, 15 p., 715209.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ascitic Fluid 100%
  • Macrophage Activation 99%
  • Peritoneal Macrophages 95%
  • Peritoneal Dialysis 94%
  • Macrophages 60%
  7 Citations (Scopus)

  2 Downloads (Pure)

• The magnitude of airway remodeling is not altered by distinct allergic inflammatory responses in BALB/c versus C57BL/6 mice but matrix composition differs

  Parkinson, J. E., Pearson, S., Rückerl, D., Allen, J. E. & Sutherland, T. E., 1 Jul 2021, In: Immunology and Cell Biology. 99, 6, p. 640-655 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Airway Remodeling 100%
  • Inbred C57BL Mouse 71%
  • Inflammation 33%
  • Collagen 21%
  • Allergens 17%
  9 Citations (Scopus)

  7 Downloads (Pure)

• IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

  Chenery, A., Rosini, S., Parkinson, J. E., Ajendra, J., Herrera, J., Lawless, C., Chan, B. H. K., Loke, P., MacDonald, A. S., Kadler, K. E., Sutherland, T. E. & Allen, J. E., 14 Jun 2021, In: Life Science Alliance. 4, 8, 14 p., e202001000.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nematode Infections 100%
  • Interleukin-13 75%
  • Lung 35%
  • Interleukin-4 15%
  • Interleukin-13 Receptors 13%
  11 Citations (Scopus)

  3 Downloads (Pure)
• 2020

  The magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice but matrix composition differs

  Parkinson, J. E., Pearson, S., Rückerl, D., Allen, J. E. & Sutherland, T. E., 21 Oct 2020, bioRxiv.

  Research output: Working paper › Preprint

  Open Access

  • Airway Remodeling 100%
  • Inbred C57BL Mouse 71%
  • Inflammation 33%
  • Allergens 26%
  • Collagen 21%

• IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

  Chenery, AL., Rosini, S., Parkinson, JE., Herrera, JA., Lawless, C., Chan, BHK., Loke, P., MacDonald, AS., Kadler, KE., Sutherland, TE. & Allen, JE., 14 Oct 2020, bioRxiv.

  Research output: Working paper › Preprint

  Open Access

  • Nematode Infections 100%
  • Interleukin-13 75%
  • Lung 35%
  • Interleukin-4 12%
  • Interleukin-13 Receptors 10%

• IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type 2 immune response to nematode infection

  Ajendra, J., Chenery, A., Parkinson, J., Chan, B. H. K., Pearson, S., Colombo, S., Boon, L., Grencis, R., Sutherland, T. & Allen, J., Jul 2020, In: Mucosal Immunology. 13, p. 958–968 11 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Nematode Infections 100%
  • Interleukin-17 69%
  • Lung 35%
  • Immunity 26%
  • Trichuriasis 12%
  3 Downloads (Pure)
• 2019

  Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung

  Chenery, A. L., Alhallaf, R., Agha, Z., Ajendra, J., Parkinson, J. E., Cooper, M. M., Chan, B. H. K., Eichenberger, R. M., Dent, L. A., Robertson, A. A. B., Kupz, A., Brough, D., Loukas, A., Sutherland, T. E., Allen, J. E. & Giacomin, P. R., 15 Nov 2019, In: Journal of Immunology. 203, 10, p. 2724-2734 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inflammasomes 100%
  • Innate Immunity 76%
  • Lung 44%
  • Helminths 28%
  • MCC950 21%
  16 Citations (Scopus)

• Crystal-clear treatment for allergic disease: Protein crystals could be targeted therapeutically to treat allergic pathology

  Allen, J. E. & Sutherland, T. E., 24 May 2019, In: Science. 364, 6442, p. 738-739 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Helminths 100%
  • lysolecithin acylhydrolase 80%
  • Asthma 64%
  • Nasal Polyps 53%
  • Pathology 52%
  15 Citations (Scopus)

• A helminth chitinase structurally similar to mammalian chitinase displays immunomodulatory properties

  Ebner, F., Balster, K., Janek, K., Niewienda, A., Malecki, P. H., Weiss, M. S., Sutherland, T. E., Heuser, A., Kühl, A. A., Zentek, J., Hofmann, A. & Hartmann, S., 17 May 2019, bioRxiv.

  Research output: Working paper › Preprint

  Open Access

  • Trichuris suis 100%
  • helminths 75%
  • chitinase 75%
  • excretory-secretory products 25%
  • mice 15%

• The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

  Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C. & MacDonald, A. S., May 2019, In: Nature Immunology. 20, 5, p. 571-580 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Alveolar Macrophages 100%
  • Inflammation 53%
  • Lung 48%
  • Interleukin-4 41%
  • Glycolysis 31%
  119 Citations (Scopus)
• 2018

  Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection

  Sutherland, T. E., Rückerl, D., Logan, N., Duncan, S., Wynn, T. A. & Allen, J. E., 30 Nov 2018, In: PLoS Pathogens. 14, 11, 27 p., : e1007423.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nematode Infections 100%
  • nematode infections 81%
  • lungs 52%
  • Lung 35%
  • immunity 23%
  39 Citations (Scopus)

• Chitinase-like proteins as regulators of innate immunity and tissue repair: helpful lessons for asthma?

  Sutherland, T., Feb 2018, In: Biochemical Society Transactions. 46, 1, p. 145-151 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitinases 100%
  • Innate Immunity 64%
  • Asthma 54%
  • Protein 28%
  • Proteins 25%
  27 Citations (Scopus)
• 2017

  Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

  Minutti, C. M., Jackson-Jones, L. H., Garcia-Fojeda, B., Knipper, J. A., Sutherland, T., Logan, N., Rinqvist, E., Guillamat-Prats, R., Ferenbach, D. A., Artigas, A., Stamme, C., Chroneos, Z. C., Zaiss, D. M., Casals, C. & Allen, J., 11 May 2017, In: Science. 356, 6342, p. 1076-1080 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophage Activation 100%
  • Pulmonary Surfactant-Associated Protein A 83%
  • Helminths 70%
  • Interleukin-4 54%
  • Lung 46%
  140 Citations (Scopus)

• Macrophage Origin Limits Functional Plasticity in Helminth-Bacterial Co-infection

  Ruckerl, D., Campbell, S. M., Duncan, S., Sutherland, T., Jenkins, S. J., Hewitson, J. P., Barr, T. A., Jackson-Jones, L. H., Maizels, R. M. & Allen, J., 23 Mar 2017, In: PLoS Pathogens. 13, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Helminths 100%
  • mixed infection 88%
  • helminths 88%
  • Coinfection 80%
  • Bacterial Infections 77%
  34 Citations (Scopus)
• 2016

  IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha

  Jackson-Jones, L. H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R. M., Sutherland, T. E., Jenkins, S. J., McSorley, H. J., Bénézech, C., MacDonald, A. S. & Allen, J. E., 1 Oct 2016, In: European Journal of Immunology. 46, 10, p. 2311–2321

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-4 Receptor alpha Subunit 100%
  • Interleukin-33 80%
  • Macrophages 41%
  • Macrophage Activation 33%
  • Pleural Cavity 25%
  29 Citations (Scopus)
• 2015

  Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.

  Knipper, J. A., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Munitz, A., Rothenberg, M. E., Niehoff, A., Richardson, R., Hammerschmidt, M., Allen, J. E. & Eming, S. A., 20 Oct 2015, In: Immunity. 43, 4, p. 803-816 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-4 Receptors 100%
  • human PLOD2 protein 79%
  • Myeloid Cells 68%
  • Lipodermatosclerosis 57%
  • 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine 56%
  232 Citations (Scopus)

• IL-17 and neutrophils: unexpected players in the type 2 immune response.

  Allen, J. E., Sutherland, T. & Ruckerl, D., 1 Jun 2015, In: Current Opinion in Immunology. 34, p. 99-106

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-17 100%
  • Chitinases 90%
  • Immunity 77%
  • Helminths 75%
  • Neutrophils 73%
  60 Citations (Scopus)

• A dominant role for the methyl-CpG-binding protein Mbd2 in controlling dendritic cell induction of type-2 inflammation

  Cook, P. C., Owen, H., Deaton, A. M., Borger, J. G., Brown, S., Clouaire, T., Jones, G-R., Jones, L. H., Lundie, R. J., Marley, A., Morrison, V. L., Phythian-Adams, A., Wachter, E., Webb, L., Sutherland, T. E., Thomas, G. D., Grainger, J., Selfridge, J., McKenzie, A. N. J., Allen, J. E., & 5 othersFagerholm, S. C., Maizels, R. M., Ivens, A. C., Bird, A. & Macdonald, A., 24 Apr 2015, In: Immunology. 143, p. 41-42 2 p.

  Research output: Contribution to journal › Abstract › peer-review

• A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

  Cook, P., Owen, H., Deaton, A. M., Borger, J. G., Brown, S., Clouaire, T., Jones, G-R., Jones, L. H., Lundie, R. J., Marley, A. K., Morrison, V. L., Phythian-Adams, A., Wachter, E., Webb, L., Sutherland, T., Thomas, G. D., Grainger, J. R., Selfridge, J., McKenzie, A. N. J., Allen, J., & 5 othersFagerholm, S. C., Maizels, R. M., Ivens, A. C., Bird, A. & MacDonald, A. S., 24 Apr 2015, In: Nature Communications. 6, 6920.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Methyl CpG Binding Domain 100%
  • induction 53%
  • Dendritic Cells 53%
  • Carrier Proteins 50%
  • proteins 47%
  64 Citations (Scopus)

  2 Downloads (Pure)
• 2014

  Uncoupling of inflammatory responses in hookworm induced emphysema

  Ringqvist, E., Sutherland, T., Duncan, S., Logan, N., Harcus, Y., Maizels, R. & Allen, J., 1 Dec 2014, In: Immunology. 143, p. 164-165 2 p.

  Research output: Contribution to journal › Abstract › peer-review

• Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.

  Sutherland, T., Logan, N., Ruckerl, D., Humbles, A. A., Allan, S., Papayannopoulos, V., Stockinger, B., Maizels, R. M. & Allen, J., 19 Oct 2014, In: Nature Immunology. 15, 12, p. 1116-1125 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitinases 100%
  • Interleukin-17 73%
  • Parasites 28%
  • Nematode Infections 26%
  • Proteins 25%
  160 Citations (Scopus)

• Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.

  Allen, J. & Sutherland, T., 1 Aug 2014, In: Seminars in Immunology. 26, 4, p. 329-340

  Research output: Contribution to journal › Article › peer-review

  • Numismatics 100%
  • Parasites 58%
  • Immunity 57%
  • Communicable Disease Control 51%
  • Helminths 42%
  186 Citations (Scopus)

• Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

  Osborne, L. C., Monticelli, L. A., Nice, T. J., Sutherland, T., Siracusa, M. C., Hepworth, M. R., Tomov, V. T., Kobuley, D., Tran, S. V., Bittinger, K., Bailey, A. G., Laughlin, A. L., Boucher, J-L., Wherry, E. J., Bushman, F. D., Allen, J., Virgin, H. W. & Artis, D., 17 Jul 2014, In: Science. 345, 6196, p. 578-582 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Helminths 100%
  • Immunomodulation 95%
  • Microbiota 82%
  • Coinfection 80%
  • Viruses 55%
  212 Citations (Scopus)
• 2012

  Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

  Ruckerl, D., Jenkins, S. J., Laqtom, N. N., Gallagher, I. J., Sutherland, T., Duncan, S., Buck, A. H. & Allen, J., 13 Sept 2012, In: Blood. 120, 11, p. 2307-2316

  Research output: Contribution to journal › Article › peer-review

  • MicroRNA 100%
  • Phosphatidylinositol 3-Kinases 80%
  • Interleukin-4 75%
  • MicroRNAs 68%
  • Macrophages 57%
  157 Citations (Scopus)

• Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus: Immunomodulation

  McSorley, H. J., O'Gorman, M. T., Blair, N., Sutherland, T. E., Filbey, K. J. & Maizels, R. M., 18 Jun 2012, In: European Journal of Immunology. 42, 10, p. 2667-2682

  Research output: Contribution to journal › Article › peer-review

  • Nematospiroides dubius 100%
  • Helminths 72%
  • Immunomodulation 68%
  • Immunity 48%
  • Inflammation 35%
  80 Citations (Scopus)
• 2011

  Analyzing airway inflammation with chemical biology

  Sutherland, T., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D. & Allen, J., 26 May 2011, In: Chemistry & Biology. 18, 5, p. 569-579 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chitinases 100%
  • bisdionin F 65%
  • Enzyme Activity 57%
  • Inflammation 40%
  • Crystal Structure 34%
  44 Citations (Scopus)

  4 Downloads (Pure)
• 2009

  Animal models of airway inflammation and airway smooth muscle remodelling in asthma

  Allen, J. E., Bischof, R. J., Sucie Chang, H-Y., Hirota, J. A., Hirst, S. J., Inman, M. D., Mitzner, W. & Sutherland, T., 1 Oct 2009, In: Pharmacology & Therapeutics. 22, 5, p. 455-465 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Smooth Muscle 100%
  • Asthma 88%
  • Animal Models 82%
  • Inflammation 66%
  • Chronic Disease 14%
  23 Citations (Scopus)

• Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies

  Maizels, R. M., Sutherland, T. & Allen, J. E., 1 Jul 2009, In: Clinical & experimental allergy. 39, 7, p. 943-955 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Chitinases 100%
  • Hypersensitivity 56%
  • Proteins 25%
  • Chitin 21%
  • Enzyme Inhibitors 12%
  78 Citations (Scopus)
• 2007

  Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice

  Langenbach, S. Y., Wheaton, B. J., Fernandes, D. J., Jones, C., Sutherland, T. E., Wraith, B. C., Harris, T., Schuliga, M. J., McLean, C. & Stewart, A. G., 22 Aug 2007, In: Canadian Journal of Physiology and Pharmacology. 85, 7, p. 727-738

  Research output: Contribution to journal › Article › peer-review

  • 2-Methoxyestradiol 100%
  • indium-bleomycin 85%
  • Bleomycin 60%
  • Glucocorticoids 57%
  • Methylprednisolone 47%
  22 Citations (Scopus)

• 2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents

  Sutherland, T. E., Anderson, R. L., Hughes, R. A., Altmann, E., Schuliga, M., Ziogas, J. & Stewart, A. G., 1 Jul 2007, In: Drug Discovery Today. 12, 13-14, p. 577-584 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-Methoxyestradiol 100%
  • Anti-Inflammatory Agent 80%
  • Anti-Inflammatory Agents 46%
  • Metabolite 44%
  • Antiangiogenic 29%
  80 Citations (Scopus)
• 2005

  2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer

  Sutherland, T. E., Schuliga, M., Harris, T., Eckhardt, B. L., Anderson, R. L., Quan, L. & Stewart, A. G., 1 Mar 2005, In: Clinical Cancer Research. 11, 5, p. 1722-1732

  Research output: Contribution to journal › Article › peer-review

  • 2-Methoxyestradiol 100%
  • Heterografts 57%
  • Estrogens 52%
  • Breast Neoplasms 40%
  • Estrogen Receptors 33%
  46 Citations (Scopus)

• The potential and suitability of 2-methoxyestradiol in cancer therapy: multiple letters

  Sidor, C., D'Amato, R., Miller, K. D., Stewart, A., Sutherland, T. E., Schuliga, M., Harris, T., Quan, L., McAllister, D., Pool, B., Eckhardt, B. & Anderson, R., 2005, In: Clinical Cancer Research. 11, 16, p. 6094-6096

  Research output: Contribution to journal › Letter
  11 Citations (Scopus)