β-Glucan exacerbates allergic airway responses to house dust mite allergen

Sabelo Hadebe; Frank Kirstein; Kaat Fierens; Pierre Redelinghuys; Graeme I. Murray; David L. Williams; Bart N. Lambrecht; Frank Brombacher; Gordon D. Brown

doi:10.1186/S12931-016-0352-5

β-Glucan exacerbates allergic airway responses to house dust mite allergen

Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown

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Abstract

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

Original language	English
Article number	35
Pages (from-to)	1-3
Number of pages	3
Journal	Respiratory Research
Volume	17
DOIs	https://doi.org/10.1186/S12931-016-0352-5
Publication status	Published - 2 Apr 2016

Keywords

B-glucans
allergy
eosinophil
T helper 2
house dust mite

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10.1186/S12931-016-0352-5Licence: CC BY

β-Glucan exacerbates allergic airway responses to house dust mite allergen
© 2016 Hadebe et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 1.19 MBLicence: CC BY

Cite this

@article{355d944f7d88498295cece3fa0d4d581,

title = "β-Glucan exacerbates allergic airway responses to house dust mite allergen",

abstract = "β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.",

keywords = "B-glucans, allergy, eosinophil, T helper 2, house dust mite",

author = "Sabelo Hadebe and Frank Kirstein and Kaat Fierens and Pierre Redelinghuys and Murray, {Graeme I.} and Williams, {David L.} and Lambrecht, {Bart N.} and Frank Brombacher and Brown, {Gordon D.}",

note = "Acknowledgements We also thank Animal Unit staff for care of the animals used in this study. Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. DLW is partly supported by National Institutes of Health GM53522, GM083016 and C06RR0306551. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection.",

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doi = "10.1186/S12931-016-0352-5",

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T1 - β-Glucan exacerbates allergic airway responses to house dust mite allergen

AU - Hadebe, Sabelo

AU - Kirstein, Frank

AU - Fierens, Kaat

AU - Redelinghuys, Pierre

AU - Murray, Graeme I.

AU - Williams, David L.

AU - Lambrecht, Bart N.

AU - Brombacher, Frank

AU - Brown, Gordon D.

N1 - Acknowledgements We also thank Animal Unit staff for care of the animals used in this study. Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. DLW is partly supported by National Institutes of Health GM53522, GM083016 and C06RR0306551. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection.

PY - 2016/4/2

Y1 - 2016/4/2

N2 - β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

AB - β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

KW - B-glucans

KW - allergy

KW - eosinophil

KW - T helper 2

KW - house dust mite

U2 - 10.1186/S12931-016-0352-5

DO - 10.1186/S12931-016-0352-5

M3 - Article

VL - 17

SP - 1

EP - 3

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

M1 - 35

ER -

β-Glucan exacerbates allergic airway responses to house dust mite allergen

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