β-Glucan exacerbates allergic airway responses to house dust mite allergen

Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown

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Abstract

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
Original languageEnglish
Article number35
Pages (from-to)1-3
Number of pages3
JournalRespiratory Research
Volume17
DOIs
Publication statusPublished - 2 Apr 2016

Keywords

  • B-glucans
  • allergy
  • eosinophil
  • T helper 2
  • house dust mite

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    Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., Lambrecht, B. N., Brombacher, F., & Brown, G. D. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17, 1-3. [35]. https://doi.org/10.1186/S12931-016-0352-5