β-Glucan exacerbates allergic airway responses to house dust mite allergen

Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown

Research output: Contribution to journalArticle

5 Citations (Scopus)
4 Downloads (Pure)

Abstract

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
Original languageEnglish
Article number35
Pages (from-to)1-3
Number of pages3
JournalRespiratory Research
Volume17
DOIs
Publication statusPublished - 2 Apr 2016

Fingerprint

Dermatophagoides Antigens
Glucans
Pyroglyphidae
Pneumonia
T-Lymphocytes
Feces
Cell Wall
Fungi

Keywords

  • B-glucans
  • allergy
  • eosinophil
  • T helper 2
  • house dust mite

Cite this

Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., ... Brown, G. D. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17, 1-3. [35]. https://doi.org/10.1186/S12931-016-0352-5

β-Glucan exacerbates allergic airway responses to house dust mite allergen. / Hadebe, Sabelo; Kirstein, Frank; Fierens, Kaat; Redelinghuys, Pierre; Murray, Graeme I.; Williams, David L.; Lambrecht, Bart N.; Brombacher, Frank; Brown, Gordon D.

In: Respiratory Research, Vol. 17, 35, 02.04.2016, p. 1-3.

Research output: Contribution to journalArticle

Hadebe, S, Kirstein, F, Fierens, K, Redelinghuys, P, Murray, GI, Williams, DL, Lambrecht, BN, Brombacher, F & Brown, GD 2016, 'β-Glucan exacerbates allergic airway responses to house dust mite allergen', Respiratory Research, vol. 17, 35, pp. 1-3. https://doi.org/10.1186/S12931-016-0352-5
Hadebe, Sabelo ; Kirstein, Frank ; Fierens, Kaat ; Redelinghuys, Pierre ; Murray, Graeme I. ; Williams, David L. ; Lambrecht, Bart N. ; Brombacher, Frank ; Brown, Gordon D. / β-Glucan exacerbates allergic airway responses to house dust mite allergen. In: Respiratory Research. 2016 ; Vol. 17. pp. 1-3.
@article{355d944f7d88498295cece3fa0d4d581,
title = "β-Glucan exacerbates allergic airway responses to house dust mite allergen",
abstract = "β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.",
keywords = "B-glucans, allergy, eosinophil, T helper 2, house dust mite",
author = "Sabelo Hadebe and Frank Kirstein and Kaat Fierens and Pierre Redelinghuys and Murray, {Graeme I.} and Williams, {David L.} and Lambrecht, {Bart N.} and Frank Brombacher and Brown, {Gordon D.}",
note = "Acknowledgements We also thank Animal Unit staff for care of the animals used in this study. Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. DLW is partly supported by National Institutes of Health GM53522, GM083016 and C06RR0306551. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection.",
year = "2016",
month = "4",
day = "2",
doi = "10.1186/S12931-016-0352-5",
language = "English",
volume = "17",
pages = "1--3",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",

}

TY - JOUR

T1 - β-Glucan exacerbates allergic airway responses to house dust mite allergen

AU - Hadebe, Sabelo

AU - Kirstein, Frank

AU - Fierens, Kaat

AU - Redelinghuys, Pierre

AU - Murray, Graeme I.

AU - Williams, David L.

AU - Lambrecht, Bart N.

AU - Brombacher, Frank

AU - Brown, Gordon D.

N1 - Acknowledgements We also thank Animal Unit staff for care of the animals used in this study. Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. DLW is partly supported by National Institutes of Health GM53522, GM083016 and C06RR0306551. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection.

PY - 2016/4/2

Y1 - 2016/4/2

N2 - β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

AB - β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

KW - B-glucans

KW - allergy

KW - eosinophil

KW - T helper 2

KW - house dust mite

U2 - 10.1186/S12931-016-0352-5

DO - 10.1186/S12931-016-0352-5

M3 - Article

VL - 17

SP - 1

EP - 3

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

M1 - 35

ER -