β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
- T helper 2
- house dust mite
Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., Lambrecht, B. N., Brombacher, F., & Brown, G. D. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17, 1-3. . https://doi.org/10.1186/S12931-016-0352-5