[18F]Fluoride Labelling of Macromolecules in Aqueous Conditions: Silicon and boroaryl based [18F]fluorine acceptors, [18F]FDG conjugation and Al18F chelation

Timothy Andrew Davies Smith

Research output: Contribution to journalLiterature review

16 Citations (Scopus)


[18F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron based fluoride acceptor molecules, [18F]FDG conjugation and chelation of the Al18F complex have been employed recently to achieve [18F]radiolabelling of macromolecules. These approaches are reviewed and their limitations outlined.
Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number8
Publication statusPublished - 30 Jun 2012



  • FDG
  • silicon
  • boron
  • peptide
  • protein
  • Al18F

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