[18F]Fluoride Labelling of Macromolecules in Aqueous Conditions: Silicon and boroaryl based [18F]fluorine acceptors, [18F]FDG conjugation and Al18F chelation

Timothy Andrew Davies Smith

Research output: Contribution to journalLiterature review

15 Citations (Scopus)

Abstract

[18F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron based fluoride acceptor molecules, [18F]FDG conjugation and chelation of the Al18F complex have been employed recently to achieve [18F]radiolabelling of macromolecules. These approaches are reviewed and their limitations outlined.
Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume55
Issue number8
DOIs
Publication statusPublished - 30 Jun 2012

Fingerprint

Fluorination
Boron
Fluorine
Halogenation
Fluorodeoxyglucose F18
Silicon
Chelation
Macromolecules
Fluorides
Labeling
Substitution reactions
Molecules

Keywords

  • FDG
  • silicon
  • boron
  • peptide
  • protein
  • Al18F

Cite this

@article{dc5fd1f6e5be49a5952d7a75d4bd580e,
title = "[18F]Fluoride Labelling of Macromolecules in Aqueous Conditions: Silicon and boroaryl based [18F]fluorine acceptors, [18F]FDG conjugation and Al18F chelation",
abstract = "[18F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron based fluoride acceptor molecules, [18F]FDG conjugation and chelation of the Al18F complex have been employed recently to achieve [18F]radiolabelling of macromolecules. These approaches are reviewed and their limitations outlined.",
keywords = "FDG, silicon, boron, peptide, protein, Al18F",
author = "Smith, {Timothy Andrew Davies}",
year = "2012",
month = "6",
day = "30",
doi = "10.1002/jlcr.2940",
language = "English",
volume = "55",
pages = "281--288",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - [18F]Fluoride Labelling of Macromolecules in Aqueous Conditions

T2 - Silicon and boroaryl based [18F]fluorine acceptors, [18F]FDG conjugation and Al18F chelation

AU - Smith, Timothy Andrew Davies

PY - 2012/6/30

Y1 - 2012/6/30

N2 - [18F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron based fluoride acceptor molecules, [18F]FDG conjugation and chelation of the Al18F complex have been employed recently to achieve [18F]radiolabelling of macromolecules. These approaches are reviewed and their limitations outlined.

AB - [18F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron based fluoride acceptor molecules, [18F]FDG conjugation and chelation of the Al18F complex have been employed recently to achieve [18F]radiolabelling of macromolecules. These approaches are reviewed and their limitations outlined.

KW - FDG

KW - silicon

KW - boron

KW - peptide

KW - protein

KW - Al18F

U2 - 10.1002/jlcr.2940

DO - 10.1002/jlcr.2940

M3 - Literature review

VL - 55

SP - 281

EP - 288

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 8

ER -