[18F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron based fluoride acceptor molecules, [18F]FDG conjugation and chelation of the Al18F complex have been employed recently to achieve [18F]radiolabelling of macromolecules. These approaches are reviewed and their limitations outlined.
|Number of pages||8|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publication status||Published - 30 Jun 2012|