3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

Claude Michel Wischik (Inventor), Janet Elizabeth Rickard (Inventor), Charles Robert Harrington (Inventor), David Horsley (Inventor), John Mervyn David Storey (Inventor), Colin Marshall (Inventor), James Peter Sinclair (Inventor), Thomas Baddeley (Inventor)

Research output: Patent

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Abstract

This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R.sup.1 and R.sup.9 is independently selected from: --H; C.sub.1-4alkyl; C.sub.2-4alkenyl; and halogenated C.sub.1-4alkyl; each of R.sup.3NA and R.sup.3NB is independently selected from: --H; C.sub.1-4alkyl; C.sub.2-4alkenyl; and halogenated C.sub.1-4alkyl; each of R.sup.7NA and R.sup.7NB is independently selected from: --H; C.sub.1-4alkyl; C.sub.2-4alkenyl; and halogenated C.sub.1-4alkyl; each of HX.sup.1 and HX.sup.2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).
Original languageEnglish
Patent numberUS7,888,350
Publication statusPublished - 15 Feb 2011

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