A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients.

K Bjordal, A de Graeff, Peter Fayers, E Hammerlid, C van Pottelsberghe, D Curran, M Ahlner-Elmqvist, E J Maher, J W Meyza, A Brédart, A L Söderholm, J J Arraras, J S Feine, H Abendstein, R P Morton, T Pignon, P Huguenin, A Bottomly, S Kaasa, EORTC Quality of Life Group

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This study tests the reliability and validity of the European Organization for Research and Treatment of Cancer (EORTC) head and neck cancer module (QLQ-H&N35) and version 3.0 of the EORTC Core Questionnaire (QLQ-C30) in 622 head and neck cancer patients from 12 countries. The patients completed the QLQ-C30, the QLQ-H&N35 and a debriefing questionnaire before antineoplastic treatment or at a follow-up. 232 patients receiving treatment completed a second questionnaire after treatment. Compliance was high and the questionnaire was well accepted by the patients. Multitrait scaling analysis confirmed the proposed scale structure of the QLQ-H&N35. The QLQ-H&N35 was responsive to differences between disease status, site and patients with different Karnofsky performance status, and to changes over time. The new physical functioning scale (with a four-point response format) of version 3.0 of the QLQ-C30 was shown to be more reliable than previous versions. Thus, the QLQ-H&N35, in conjunction with the QLQ-C30, appears to be reliable, valid and applicable to broad multicultural samples of head and neck cancer patients.
Original languageEnglish
Pages (from-to)1796-1807
Number of pages12
JournalEuropean Journal of Cancer
Issue number14
Publication statusPublished - Sep 2000



  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell
  • Female
  • Head and Neck Neoplasms
  • Health Status Indicators
  • Humans
  • Male
  • Middle Aged
  • Quality of Life
  • Questionnaires
  • Sensitivity and Specificity
  • Time Factors
  • quality of life
  • head and neck cancer
  • assessment
  • questionnaire
  • validation

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