A common cause for a common phenotype

the gatekeeper hypothesis in fetal programming

S McMullen, S C Langley-Evans, L Gambling, C Lang, A Swali, H J McArdle

Research output: Contribution to journalArticle

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Abstract

Sub-optimal nutrition during pregnancy has been shown to have long-term effects on the health of offspring in both humans and animals. The most common outcomes of such programming are hypertension, obesity, dyslipidaemia and insulin resistance. This spectrum of disorders, collectively known as metabolic syndrome, appears to be the consequence of nutritional insult during early development, irrespective of the nutritional stress experienced. For example, diets low in protein diet, high in fat, or deficient in iron are all associated with programming of cardiovascular and metabolic disorders when fed during rat pregnancy. In this paper, we hypothesise that the nutritional stresses act on genes or gene pathways common to all of the insults. We have termed these genes and/or gene pathways the "gatekeepers" and hence developed the "gatekeeper hypothesis". In this paper, we examine the background to the hypothesis and postulate some possible mechanisms or pathways that may constitute programming gatekeepers.
Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalMedical hypotheses
Volume78
Issue number1
Early online date1 Nov 2011
DOIs
Publication statusPublished - Jan 2012

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Fetal Development
Phenotype
Genes
Prenatal Nutritional Physiological Phenomena
Protein-Restricted Diet
Dyslipidemias
Insulin Resistance
Iron
Obesity
Fats
Diet
Hypertension
Pregnancy
Health

Cite this

A common cause for a common phenotype : the gatekeeper hypothesis in fetal programming. / McMullen, S; Langley-Evans, S C; Gambling, L; Lang, C; Swali, A; McArdle, H J.

In: Medical hypotheses, Vol. 78, No. 1, 01.2012, p. 88-94.

Research output: Contribution to journalArticle

McMullen, S ; Langley-Evans, S C ; Gambling, L ; Lang, C ; Swali, A ; McArdle, H J. / A common cause for a common phenotype : the gatekeeper hypothesis in fetal programming. In: Medical hypotheses. 2012 ; Vol. 78, No. 1. pp. 88-94.
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