A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Daniel A. Berg, Yijing Su, Dennisse Jimenez-Cyrus, Aneek Patel, Nancy Huang, David Morizet, Stephanie Lee, Reeti Shah, Francisca Rojas Ringeling, Rajan Jain, Jonathan A. Epstein, Qing Feng Wu, Stefan Canzar, Guo Li Ming*, Hongjun Song, Allison M. Bond

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to proliferative Hopx+ neural progenitors in the primitive dentate region, and they, in turn, generate granule neurons, but not other neurons, throughout development and then transition into Hopx+ quiescent radial glial-like neural progenitors during an early postnatal period. RNA-seq and ATAC-seq analyses of Hopx+ embryonic, early postnatal, and adult dentate neural progenitors further reveal common molecular and epigenetic signatures and developmental dynamics. Together, our findings support a “continuous” model wherein a common neural progenitor population exclusively contributes to dentate neurogenesis throughout development and adulthood. Adult dentate neurogenesis may therefore represent a lifelong extension of development that maintains heightened plasticity in the mammalian hippocampus.

Original languageEnglish
Pages (from-to)654-668 and e1-e15
Number of pages31
JournalCell
Volume177
Issue number3
Early online date28 Mar 2019
DOIs
Publication statusPublished - 18 Apr 2019

Keywords

  • brain development
  • chromatin landscape profiling
  • dentate gyrus
  • gene expression profiling
  • hippocampus
  • Hopx
  • lineage tracing
  • neural stem cells
  • neurogenesis

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    Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., Epstein, J. A., Wu, Q. F., Canzar, S., Ming, G. L., Song, H., & Bond, A. M. (2019). A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. Cell, 177(3), 654-668 and e1-e15. https://doi.org/10.1016/j.cell.2019.02.010