A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome

Z G Fang, Ken J. Forbes

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Abstract

A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalJournal of Clinical Microbiology
Volume35
Issue number2
Publication statusPublished - Feb 1997

Keywords

  • complex strains
  • element
  • epidemiology
  • tool

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